Pancreatic cancer–associated thrombosis

Hong Kong Med J 2023 Oct;29(5):378–9 | Epub 10 Oct 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Pancreatic cancer–associated thrombosis
Tommy HC Tam, FRCP (Glasg), FHKAM (Medicine)1; Rashid N Lui, FRCP (Lond), FHKAM (Medicine)2,3
1 Division of Haematology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China
2 Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China
3 Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
 
Corresponding author: Dr Tommy HC Tam (tommytam@cuhk.edu.hk)
 
 Full paper in PDF
 
 
Malignancy is a well-known cause of clinically significant vascular thrombosis, associated with a 7- to 28-fold increase in the risk of venous thromboembolism across all cancers.1 Pancreatic cancer is among several malignancies with the highest risk of cancer-associated thrombosis (CAT).2 Nevertheless, current knowledge of CAT is mostly extrapolated from studies involving Western populations. Data from the Chinese population in Hong Kong are limited; therefore, management strategies for such patients remain controversial. The recent study by Chan et al3 provides some insight regarding this important topic.
 
The pathogenesis of CAT is usually multifactorial, with contributions from tumour-derived factors and extrinsic factors. Different tumour subtypes have distinct tendencies to express procoagulation molecules such as tissue factors, microparticles, podoplanin, plasminogen activator inhibitor-1, thrombin, and adenosine diphosphate. The presence of these molecules leads to a hypercoagulable state, which is exacerbated by inflammation involving various cytokines and chemokines (eg, tissue necrosis factor alpha, interleukin-1, and vascular endothelial growth factor). In addition to the tumour-derived factors mentioned above, extrinsic factors including vascular obstruction, immobility, anti-cancer therapy, indwelling catheters, and superimposed infection can also contribute to CAT pathogenesis through diverse mechanisms.4 These factors may be particularly relevant in the setting of pancreatic cancer, considering the central abdominal location of the pancreas and its close proximity to major blood vessels.
 
Low-molecular-weight heparin has been regarded as the gold-standard pharmacological treatment for CAT, based on the findings of the 2003 CLOT study (Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer).5 However, the era of direct oral anticoagulants has arrived. These newer agents have demonstrated non-inferiority in CAT treatment, compared with the gold-standard low-molecular-weight heparin, during multiple pivotal trials such as the Caravaggio study (apixaban),6 SELECT-D (rivaroxaban),7 and Hokusai VTE Cancer trial (edoxaban).8 Multiple international guidelines have endorsed the use of these agents in CAT treatment, along with the conventional low-molecular-weight heparin and the less favourable warfarin.9 10 11
 
In this issue of the Hong Kong Medical Journal, Chan et al3 reveal that the overall incidence of CAT is approximately 15% in a predominantly Chinese population, which is lower than the reported incidences in Western populations (ie, 20%-40%).12 13 Multivariable analysis showed that stage IV disease was a significant risk factor for CAT, whereas the presence of CAT and its subsequent treatment did not significantly influence overall survival. The authors suggested that the absence of a survival benefit with CAT treatment was related to the underlying advanced malignancy status, which can lead to a guarded disease prognosis. Additionally, gastrointestinal bleeding (eg, from varices secondary to venous thrombosis, tumour invasion, or haemobilia) may have had a negative impact on survival.
 
Future studies will be useful in identifying subgroups of patients with pancreatic cancer who may benefit from therapeutic or even prophylactic anticoagulation, along with the characteristics of patients for whom anticoagulation is considered futile or carries an unacceptable risk of bleeding. Explorations of optimal pharmacological treatment approaches should focus on direct oral anticoagulants, considering that patients in the current study were treated between 2010 and 2015, prior to the era of CAT treatment via direct oral anticoagulants. Finally, meaningful insights could be gained by investigating the effects of various pharmacological treatments on patient-reported quality of life measures.
 
Author contributions
Both authors contributed to the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
Both authors have declared no conflicts of interest.
 
References
1. Noble S, Pasi J. Epidemiology and pathophysiology of cancer-associated thrombosis. Br J Cancer 2010;102 Suppl 1:S2-9. Crossref
2. Epstein AS, Soff GA, Capanu M, et al. Analysis of incidence and clinical outcomes in patients with thromboembolic events and invasive exocrine pancreatic cancer. Cancer 2012;118:3053-61. Crossref
3. Chan LL, Lam KY, Lam DC, et al. Risks and impacts of thromboembolism in patients with pancreatic cancer. Hong Kong Med J 2023 Oct 4. Epub ahead of print. Crossref
4. Abdol Razak NB, Jones G, Bhandari M, Berndt MC, Metharom P. Cancer-associated thrombosis: an overview of mechanisms, risk factors, and treatment. Cancers (Basel) 2018;10:380. Crossref
5. Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 2003;349:146-53. Crossref
6. Agnelli G, Becattini C, Meyer G, et al. Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 2020;382:1599-607. Crossref
7. Young AM, Marshall A, Thirlwall J, et al. Comparison of an oral factor Xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: results of a randomized trial (SELECT-D). J Clin Oncol 2018;36:2017-23. Crossref
8. Raskob GE, van Es N, Verhamme P, et al. Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 2018;378:615-24. Crossref
9. Lyman GH, Kuderer NM. Clinical practice guidelines for the treatment and prevention of cancer-associated thrombosis. Thromb Res 2020;191 Suppl 1:S79-84. Crossref
10. Streiff MB, Holmstrom B, Angelini D, et al. Cancer-associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2021;19:1181-201.
11. Lyman GH, Carrier M, Ay C, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv 2021;5:927-74. Crossref
12. Frere C. Burden of venous thromboembolism in patients with pancreatic cancer. World J Gastroenterol 2021;27:2325-40. Crossref
13. Campello E, Ilich A, Simioni P, Key NS. The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues. Br J Cancer 2019;121:359-71. Crossref

Shaping the ‘Family Doctor for All’ system through the Chronic Disease Co-Care Pilot Scheme

Hong Kong Med J 2023 Oct;29(5):375–7 | Epub 12 Sep 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Shaping the ‘Family Doctor for All’ system through the Chronic Disease Co-Care Pilot Scheme
Esther YT Yu, FHKAM (Family Medicine), FRACGP; Tony KH Ha, FHKAM (Community Medicine), FRACMA; FC Pang, FHKAM (Medicine), FHKAM (Community Medicine)
Primary Healthcare Office, Health Bureau, Hong Kong SAR Government, Hong Kong SAR, China
 
Corresponding author: Dr Tony KH Ha (tkhha@healthbureau.gov.hk)
 
 Full paper in PDF
 
 
Introduction
Type 2 diabetes mellitus (DM) and hypertension combined were responsible for over 200 million DALYs (disability-adjusted life years) worldwide, representing the sum of years of life lost to premature mortality plus years lived with disability arising from these two highly prevalent conditions.1 2 Population-based preventive measures (eg, promotion of healthy lifestyles and targeted screening of at-risk individuals) followed by early team-based intervention have been effective strategies for reducing the associated morbidity, mortality, and healthcare burden.3 4 In countries with mature primary healthcare systems, these services are led by family doctors (ie, general practitioners) who partner with multidisciplinary healthcare teams to provide personalised, continuous, and comprehensive holistic care for all community residents.5 6 7
 
Hong Kong has a treatment-oriented healthcare system, in which 90% of hospital-based services are provided by the public sector8 and approximately 50% of public general outpatient services are used to manage DM and hypertension.9 Population-based preventive care initiatives, such as anti-smoking campaigns, the Colorectal Cancer Screening Programme (CRCSP) and the Vaccination Subsidy Scheme (VSS), have been successful but sporadic; they have limited potential to empower participants to pursue healthy living over life course. There is no structured cardiovascular disease screening programme in the public sector for most at-risk citizens without their own family doctors,10 except for older adults aged ≥65 years. Consequently, the public healthcare system has been heavily strained by the increasing prevalence of chronic diseases such as hypertension and DM, along with complications resulting from delayed diagnosis.
 
To improve healthcare system sustainability and overall population health, the Government recognises the urgent need to establish a prevention-oriented primary healthcare system. The Primary Healthcare Blueprint, issued in December 2022, highlighted key areas of development needed to address gaps in preventive care, continuity of care, and community participation. An important strategy is to implement the ‘Family Doctor for All’ concept by establishing a family doctor registration system: the Primary Care Register (PCR).11 The PCR is intended to build a recognition system for doctors who are committed to providing comprehensive, continuous, and holistic care to patients in the community; such care ranges from preventive services to chronic disease management.
 
Family doctors in the Primary Care Register
Private doctors have been providing approximately 70% of episodic outpatient care in the community.8 However, the health advocacy potential of family doctors was not fully recognised by the public until the expansion of family medicine training in 2004. Beginning in 2013, the Government established a Primary Care Directory (PCD) to recruit primary care doctors (ie, any doctor in the private sector who was committed to providing primary care) for participation in various prevention-based programmes, such as the VSS and the CRCSP. To promote the community participation necessary for desired health improvements, the Government subsidised participants for each consultation conducted within these programmes. Because PCD registration was a prerequisite for receipt of related subsidies, PCD doctors were often engaged by the programme-based funding model. However, this model does not promote continuity of care if participants choose to consult PCD doctors only for specific preventive care services, or if the PCD doctors choose to only provide the specific preventive care services to the scheme participants during consultation.
 
To encourage community-based management of stable chronic diseases and reduce the service burden within the public healthcare sector, the Hospital Authority (HA) implemented the General Outpatient Clinic Public-Private Partnership Programme as an outsourcing service, beginning in 2014.12 However, the working relationship was unilateral. As the funder, the HA would purchase doctors’ services for specific tasks at prices determined through a bidding process; as service providers, PCD doctors would charge fees based on the service agreement. Benefits to patients were not considered in this programme. Similarly, doctors’ efforts to deliver holistic care beyond the scope of the service agreement were not appreciated or supported. Both models regarded PCD doctors as Government agents for service delivery and contributed to the fragmentation of care. Thus, these models failed to encourage the establishment of long-term doctor-patient partnerships necessary to enhance overall population health through patientcentric care.
 
In contrast, the planned PCR recognises the robust potential of family doctors. Under the PCR, each citizen will be paired with their preferred family doctor; each paired family doctor will be the only doctor eligible to receive any subsidy allocated to the paired patient, including existing programme-based subsidies (eg, the VSS, the CRCSP, and the General Outpatient Clinic Public-Private Partnership Programme) and any future initiatives to support primary healthcare. In addition to subsidies, efforts to optimise holistic care require community-based multidisciplinary team support for family doctors. Community drug formularies will be established to ensure that family doctors have access to common medications at affordable prices, which will facilitate long-term patient management. Community nurses and allied health professionals at District Health Centres will empower patients in leading healthy lifestyles and managing their own health. To encourage best practices, family doctors who have fulfilled their preventive and chronic disease care obligations, such as the provision of seasonal influenza vaccination, will be rewarded through additional payments.
 
The Chronic Disease Co-Care Pilot Scheme
The Chronic Disease Co-Care Pilot Scheme (the Scheme) targeting DM and hypertension, which will be launched in November 2023, represents the prototype service model under the planned PCR. People aged ≥45 years without a known diagnosis of DM or hypertension will be eligible for enrolment in a subsidised screening programme consisting of laboratory tests and a medical consultation with a paired family doctor registered in the current PCD. Healthy participants will be offered education regarding a healthy lifestyle and the opportunity to undergo repeat screening every 3 years. Participants with prediabetes, DM, and/or hypertension will receive subsidised care, including laboratory investigations for chronic disease monitoring, from their paired family doctor and a multidisciplinary team in the community.
 
To support PCD doctors in this new role, the Scheme incorporates seven key components that will shape the future primary healthcare system when the Primary Healthcare Commission (PHC) is established in 2024. These components include: (1) pairing of family doctors with participants; (2) District Health Centres and their services; (3) subsidised multidisciplinary services in the community; (4) protocol-driven bi-directional referral with designated medical specialist clinics under the HA; (5) pay-for-performance incentives for both participants and family doctors; (6) community drug formularies to ensure that family doctors have access to common medications at affordable prices; and (7) uniform data sharing in the Electronic Health Record Sharing System platform with participant consent. An important objective of the Scheme is to attract and build a pool of future PCR family doctors who agree with our vision and are committed to delivering quality primary care for our fellow citizens. The ultimate goals of the Scheme are to shift population-level health-seeking behaviour from treatment-oriented to prevention-focused, to encourage shared responsibility for personal health at an affordable cost, to enable family doctors to maintain continuity of care, and to improve health for all.
 
Conclusion
The Scheme establishes a new framework for primary healthcare involving family doctors and community services. Upon establishment of the PHC, a quality assurance system will be constructed to guide clinical practice among healthcare professionals via service quality standards and reference frameworks. The PHC will also monitor the performance of subsidised services and drive continuous quality improvement through pay-forperformance incentives. Additional subsidy tiers will be established based on clinical complexity and doctors’ qualifications. Hopefully, the Scheme will encourage more doctors to enrol in the PCD, and work as Family Doctors to provide continuous, comprehensive, and patient-centric care to all citizens.
 
Author contributions
All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
The authors have declared no conflict of interest.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
References
1. Safiri S, Karamzad N, Kaufman JS, et al. Prevalence, deaths and disability-adjusted-life-years (DALYs) due to type 2 diabetes and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. Front Endocrinol (Lausanne) 2022;13:838027. Crossref
2. World Health Organization. The Global Health Observatory: blood pressure/ hypertension. 2023. Available from: https://www.who.int/data/gho/indicator-metadata-registry/imr-details/3155. Accessed 18 Aug 2023.
3. ElSayed NA, Aleppo G, Aroda VR, et al. 3. Prevention or delay of type 2 diabetes and associated comorbidities: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S41-8. Crossref
4. Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and control of hypertension: JACC Health Promotion Series. J Am Coll Cardiol 2018;72:1278-93. Crossref
5. Government of Canada. Primary health care. 2015. Available from: https://www.canada.ca/en/health-canada/services/primary-health-care.html. Accessed 18 Aug 2023.
6. Australian Institute of Health and Welfare. Primary health care in Australia. 2021. Available from: https://www.aihw.gov.au/reports/primary-health-care/primary-health-care-in-australia/contents/about-primary-health-care. Accessed 18 Aug 2023.
7. National Health Service, the United Kingdom Government. Primary care. 2020. Available from: https://www.longtermplan.nhs.uk/areas-of-work/primary-care/. Accessed 18 Aug 2023.
8. Schooling CM, Hui LL, Ho LM, Lam TH, Leung GM. Cohort profile: ‘children of 1997’: a Hong Kong Chinese birth cohort. Int J Epidemiol 2012;41:611-20. Crossref
9. Health Bureau, Hong Kong SAR Government. Legislative Council Brief. Primary Healthcare Blueprint. 2023. Available from: https://www.legco.gov.hk/yr2023/english/brief/hb202301_20230120-e.pdf. Accessed 18 Aug 2023.
10. Census and Statistics Department, Hong Kong SAR Government. Thematic Household Survey Report No. 74. 2021. Available from: https://www.censtatd.gov.hk/en/data/stat_report/product/C0000015/att/B11302742021XXXXB0100.pdf. Accessed 18 Aug 2023.
11. Health Bureau, Hong Kong SAR Government. Primary Healthcare Blueprint. 2022. Available from: https://www.primaryhealthcare.gov.hk/en/. Accessed 29 Aug 2023.
12. Electronic Health Record Sharing System, Hong Kong SAR Government. Public-Private Partnership Programmes (PPP). 2020. Available from: https://www.ehealth.gov.hk/en/whats-new/partnership/public-private-partnership-programmes.html. Accessed 1 Sep 2023.

Quality of primary healthcare in China: challenges and strategies

Hong Kong Med J 2023 Oct;29(5):372–4 | Epub 5 Oct 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Quality of primary healthcare in China: challenges and strategies
A Wang, PhD1; B Zhu, PhD2; J Huang, PhD3,4; Martin CS Wong, PhD3,4,5,6,7; H Xue, PhD8
1 School of Economics and Management, Xidian University, Xi’an, China
2 School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China
3 Centre for Health Education and Health Promotion, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
4 Editor-in-Chief, Hong Kong Medical Journal
5 School of Public Health, Fudan University, Shanghai, China
6 The Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
7 School of Public Health, Peking University, Beijing, China
8 Stanford Center on China’s Economy and Institutions, Freeman Spogli Institute for International Studies, Stanford University, Stanford, United States
 
Corresponding author: Dr B Zhu (zhub6@sustech.edu.cn)
 
 Full paper in PDF
 
 
China has experienced significant economic growth and social progress, leading to remarkable improvements in living standards and life expectancy.1 Because of substantial increases in financial investment and the implementation of new policies, the primary healthcare system in the country has made considerable progress in the prevention and management of chronic diseases. However, several challenges persist in the provision of high-quality primary healthcare in China.2 Considering the impact of the coronavirus disease 2019 pandemic and the arrival of the intelligence age, there is increasing awareness of the need for novel technologies and innovative strategies to advance the quality of primary healthcare.3 4 This awareness is particularly important in the context of ageing population and the growing burden of chronic illnesses.5 The quality of primary healthcare in China requires careful appraisal, with a specific focus on three key factors that contribute to suboptimal healthcare outcomes: insufficient knowledge among healthcare providers, a substantial knowledge and practice gap (ie, know-do gap), and disparities in health workforce distribution.6 This editorial explores potential mitigation strategies for the aforementioned issues, which could ultimately enhance the quality of primary healthcare in China.
 
Insufficient knowledge
Primary healthcare providers in China, especially in rural areas, often lack the necessary knowledge to achieve optimal health outcomes.7 A cross-sectional study showed that these knowledge deficiencies can be categorised into three main areas, namely, understanding of disease symptoms, process of diagnosis, and knowledge of medications.8 Importantly, these knowledge deficiencies may contribute to misdiagnosis, overtreatment, and poor healthcare outcomes. To ensure high-quality healthcare, healthcare providers must have a comprehensive understanding of prevalent diseases and their symptoms, such as diarrhoea, heart disease, tuberculous, dementia, and childhood epilepsy.9 10 11 Similarly, they must have knowledge of diagnostic and therapeutic processes, including communication with patients, distinction among diseases, and making appropriate treatment decisions.12 13 Furthermore, primary healthcare providers often lack sufficient knowledge regarding medications, particularly antibiotics.8 14 This lack of knowledge can lead to overuse or misuse, thereby promoting antibiotic resistance among pathogenic bacteria. The lack of knowledge can mainly be attributed to two factors: lack of appropriate training15 and inadequate collaboration and teamwork.16
 
To address these issues, the government should invest in appropriate medical training, including educational workshops or programmes to promote collaboration and teamwork among local healthcare providers. This investment could help bridge the knowledge gap, while ensuring that patients receive comprehensive and coordinated care. Moreover, primary healthcare facilities would benefit from investments in computer-aided diagnostic systems (which are widely used in tertiary hospitals) to improve diagnostic accuracy, while promoting intelligent and appropriate use of medications.
 
Large know-do gap
The know-do gap, a key barrier to high-quality healthcare in China, amplifies the impact of insufficient knowledge among healthcare providers.7 17 18 19 This gap refers to the difference between practices that primary care providers know they should use and practices that they implement in the clinic. In resource-limited areas, the gap is often greater because of factors such as limited funding, staffing shortages, inadequate infrastructure, and low incentives.20 The substantial know-do gap hinders the implementation of evidence-based practices and delivery of high-quality care to the Chinese population.
 
Potential solutions to this challenge include changing incentive structures for primary care providers16 and adopting telemedicine.21 Current incentivisation practices in China prioritise patient volume over healthcare quality. If incentives are modified to prioritise healthcare quality, primary care providers may be more motivated to invest in continuous training and education with the goal of enhancing patient-centred care.1 Moreover, telemedicine can provide remote support and resources for primary care providers serving underprivileged populations, allowing them real-time access to expertise and guidance.22 Overall, elimination of the know-do gap in primary care in China will require a comprehensive and multifaceted approach that includes changing incentives and utilising technology to improve healthcare delivery.
 
Disparities in health workforce distribution
China has the highest numbers of health professionals worldwide, from the level of primary healthcare to the level of tertiary hospitals; it also has the most diverse health workforce.23 The continuity of care within tertiary hospitals is the greatest challenge that must be addressed by the primary healthcare system. In China, primary healthcare providers usually are not the first point of contact; this approach limits opportunities to integrate clinical care and public health services, leading to insufficient continuity of care throughout the healthcare system. Because hospitals and primary health institutions typically are administered and funded separately, the electronic medical record system and healthcare management are fragmented and isolated; thus, joint healthcare efforts are difficult. In some villages and communities, a pilot programme has been established to ensure that each resident is registered with a primary healthcare provider for access to high-quality healthcare; however, this programme requires further optimisation.2 A major obstacle to healthcare access in China is the uneven distribution of the health workforce; central and western regions of China struggle to attract health workers because of economic underdevelopment and unfavourable geographical conditions (eg, inconvenient transportation, poor living conditions, and limited opportunities for professional development).23 24 Furthermore, urban areas often receive greater healthcare resources, hindering the achievement of equitable healthcare access in rural and remote areas.25 Despite substantial effort by the government to improve the economic statuses of vulnerable regions and rural areas, fundamental economic limitations may impede future attempts to close the gap in regional healthcare access.
 
Critical issues here include the quantity, diversity, and combinations of skill sets. Effective institutional arrangements, deliberate policy design, and efficient human resource management initiatives should be implemented to educate, recruit, and retain health professionals, preventing the loss of this workforce from underprivileged regions. An important initiative is healthcare integration, which links/integrates three or four levels of healthcare, facilitating coordination via telehealth or collaborations that include healthcare professionals, financial services, patient demographic and medical information, public healthcare services, and logistics services. Another important initiative is the ongoing Rural Medical Education Scheme, which provides financial assistance and tuition waivers for medical graduates from rural regions who agree to serve in primary-level healthcare facilities in their home regions for a specific length of time after graduation.26 The Scheme is helping to promote a balanced health workforce by addressing the difficulties involved in recruiting health workers to rural areas, which are the regions with the most severe healthcare staffing shortages.
 
Summary
An organised and concerted effort to enhance the quality of primary healthcare in China is needed to improve the well-being at the population level, as stated in the Healthy China 2030 initiative. Although significant progress has been made towards this goal, some gaps require further attention. More detailed policy plans should be developed to address these gaps, including strategies to enhance knowledge through training and education involving computer-aided diagnostic systems, incentivise elimination of the know-do gap through initiatives such as telemedicine, and balance health workforce distribution through innovative approaches. Efforts to implement these strategies should consider current conditions within the Chinese healthcare system.
 
Author contributions
A Wang, B Zhu and H Xue contributed to the concept, design and drafting of the editorial. J Huang and MCS Wong contributed to critical revision of the editorial for important intellectual content. All authors had full access to the data, contributed to the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
All authors have disclosed no conflicts of interest.
 
Funding/support
This editorial was funded by the National Natural Science Foundation of China (Ref No.: 71903149), Guangdong Basic and Applied Basic Research Foundation (Ref No.: 2022A1515011871), and Foundation of Humanities and Social Science of the Ministry of Education, China (Ref No.: 19YJCZH151). The funders had no role in study design, data collection/analysis/interpretation, or manuscript preparation.
 
Ethics approval
The requirement for ethical approval was waived by the institutional review board of the Southern University of Science and Technology due to the use of secondary data in the study.
 
References
1. Ma X, Wang H, Yang L, Shi L, Liu X. Realigning the incentive system for China’s primary healthcare providers. BMJ 2019;365:I2406. Crossref
2. Li X, Krumholz HM, Yip W, et al. Quality of primary health care in China: challenges and recommendations. Lancet 2020;395:1802-12. Crossref
3. Yang C, Yin J, Liu J, et al. The roles of primary care doctors in the COVID-19 pandemic: consistency and influencing factors of doctor’s perception and actions and nominal definitions. BMC Health Serv Res 2022;22:1143. Crossref
4. Xue H, D’Souza K, Fang Y, et al. Direct-to-consumer telemedicine platforms in China: a national market survey and quality evaluation. Available from: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3944587. Accessed 15 Jun 2023.
5. Wang HH, Li YT, Zhang Y, Wong MC. Revisiting primary healthcare and looking ahead. Hong Kong Med J 2023;29:96-8. Crossref
6. Nie J, Shi Y, Xue H. Why is a special section “Healthcare in Mainland China” so crucial for HKMJ? Hong Kong Med J 2022;28:6. Crossref
7. Shi Y, Yi H, Zhou H, et al. The quality of primary care and correlates among grassroots providers in rural China: a cross-sectional standardised patient study. Lancet 2017;390:S16. Crossref
8. Xue H, Shi Y, Huang L, et al. Diagnostic ability and inappropriate antibiotic prescriptions: a quasiexperimental study of primary care providers in rural China. J Antimicrob Chemother 2019;74:256-63. Crossref
9. Du S, Cao Y, Zhou T, et al. The knowledge, ability, and skills of primary health care providers in SEANERN countries: a multi-national cross-sectional study. BMC Health Serv Res 2019;19:602. Crossref
10. Xue H, Nie J, Shi Y. Crucial role of primary healthcare professionals in the assessment and diagnosis of dementia. Hong Kong Med J 2019;25:427-8. Crossref
11. Yi H, Liu H, Wang Z, et al. The competence of village clinicians in the diagnosis and management of childhood epilepsy in Southwestern China and its determinants: a cross-sectional study. Lancet Reg Health West Pac 2020;3:100031. Crossref
12. Guo W, Sylvia S, Umble K, Chen Y, Zhang X, Yi H. The competence of village clinicians in the diagnosis and treatment of heart disease in rural China: a nationally representative assessment. Lancet Reg Health West Pac 2020;2:100026. Crossref
13. Zhou Q, An Q, Wang N, et al. Communication skills of providers at primary healthcare facilities in rural China. Hong Kong Med J 2020;26:208-15. Crossref
14. Bai Y, Wang S, Yin X, Bai J, Gong Y, Lu Z. Factors associated with doctors’ knowledge on antibiotic use in China. Sci Rep 2016;6:23429. Crossref
15. Yi H, Wu P, Zhang X, Teuwen DE, Sylvia S. Market competition and demand for skills in a credence goods market: evidence from face-to-face and web-based non-physician clinician training in rural China. PLoS One 2020;15:e0233955. Crossref
16. Li X, Lu J, Hu S, et al. The primary health-care system in China. Lancet 2017;390:2584-94. Crossref
17. Xue H, Hager J, An Q, et al. The quality of tuberculosis care in urban migrant clinics in China. Int J Environ Res Public Health 2018;15:2037. Crossref
18. Sylvia S, Xue H, Zhou C, et al. Tuberculosis detection and the challenges of integrated care in rural China: a cross-sectional standardized patient study. PLoS Med 2017;14:e1002405. Crossref
19. Sylvia S, Shi Y, Xue H, et al. Survey using incognito standardized patients shows poor quality care in China’s rural clinics. Health Policy Plan 2015;30:322-33. Crossref
20. Wang HH, Li YT, Duan H, Wong MC. Physician motivation and satisfaction matter in healthcare. Hong Kong Med J 2023;29:8-10. Crossref
21. Cheng TC, Fu H, Xu D, Yip W. Technology platforms are revolutionizing health care service delivery in China. NEJM Catalyst 2022. doi: 10.1056/CAT.21.0414. Crossref
22. Cui F, He X, Zhai Y, et al. Application of telemedicine services based on a regional telemedicine platform in China from 2014 to 2020: longitudinal trend analysis. J Med Internet Res 2021;23:e28009. Crossref
23. Zhu B, Hsieh C, Mao Y. Spatio-temporal variations of licensed doctor distribution in China: measuring and mapping disparities. BMC Health Serv Res 2020;20:159. Crossref
24. Shi Y, Song S, Peng L, et al. Utilisation of village clinics in Southwest China: evidence from Yunnan Province. Hong Kong Med J 2022;28:306-14. Crossref
25. Chen L, Zeng H, Wu L, et al. Spatial accessibility evaluation and location optimization of primary healthcare in China: a case study of Shenzhen. Geohealth 2023;7:e2022GH000753. Crossref
26. Liu J, Zhang K, Mao Y. Attitude towards working in rural areas: a cross-sectional survey of rural-oriented tuition-waived medical students in Shaanxi, China. BMC Med Educ 2018;18:91. Crossref

Rejuvenation of retinopathy of prematurity

Hong Kong Med J 2023 Aug;29(4):284–6 | Epub 10 Aug 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Rejuvenation of retinopathy of prematurity
Tracy HT Lai, MSc (Epidemiology) (Lond), FHKAM (Ophthalmology)1,2; Paul RV Chan, MD, FACS3; Kenneth KW Li, FRCOphth (UK), FHKAM (Ophthalmology)2
1 Department of Ophthalmology, United Christian Hospital and Tseung Kwan O Hospital, Hong Kong SAR, China
2 Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
3 Department of Ophthalmology, University of Illinois College of Medicine, Chicago, United States
 
Corresponding author: Dr Kenneth KW Li (lkw856@ha.org.hk)
 
 Full paper in PDF
 
 
In 1942, TL Terry was the first to report a condition that he termed ‘retrolental fibroplasia’, which developed in premature infants with low birth weight (BW)—this condition is now known as retinopathy of prematurity (ROP).1 Insufficient retinal vasculature development can lead to abnormal blood vessel growth, typically at the junction of the peripheral vascular and avascular retina. Subsequent fibrosis onset can result in retinal detachment and fibrovascular mass formation behind the crystalline lens (ie, retrolental fibroplasia). Oxygen therapy contributes to ROP onset.2 In the vasoconstrictive phase, oxygen can inhibit retinal vascularisation and suppress the production of vascular endothelial growth factor (VEGF). During the vasoproliferative phase, increased VEGF levels can cause neovascularisation and retinal blood vessel dilatation. Meticulous control of hyperoxia (arterial oxygen saturation >92%-93%) and avoidance of fluctuations in arterial oxygen saturation could prevent severe ROP.3
 
Appropriate treatment can protect against ROP-related blindness. Treatment largely depends on the location (zone) and severity of neovascularisation (stage), as well as a confirmed need for treatment. Historically, ROP was initially managed by avascular retina–targeted cryotherapy to reduce ischaemic drive. In the Cryotherapy for ROP (CRYO-ROP) study, adverse outcomes (retinal detachment, macula fold or retrolental mass) were reduced by almost 50% in eyes that received cryotherapy.4 In the 2000s, laser photocoagulation largely replaced cryotherapy as conventional treatment. The Early Treatment for ROP (ETROP) trial established standard treatment recommendations for type 1 (treatment-warranted) ROP: zone II ROP, stage 2 or 3 with plus disease, and zone 1 ROP, stage 3 with or without plus disease.5 Since then, the intravitreal injection of anti-VEGF drugs, including bevacizumab, ranibizumab, and aflibercept, has gained broad acceptance in the treatment of ROP; laser is still a popular option for primary therapy as well as rescue therapy (eg, in cases of disease reactivation and persistent avascular retina). The Bevacizumab Eliminates the Angiogenic Threat of ROP (BEAT-ROP) study showed promising results when bevacizumab was used in the treatment of stage 3 ROP; the retreatment rate was 4%, compared with 22% in the laser group.6 The ranibizumab compared with laser therapy for the treatment of infants born prematurely with ROP (RAINBOW) study also revealed excellent treatment success in 80% of infants receiving ranibizumab, compared with 66% of infants receiving laser therapy.7 Late complications, such as high myopia (-5 dioptres or worse), were less frequent after ranibizumab (5%) than after laser therapy (16%).8 Systemic complications did not differ between groups; the incidences of motor and hearing problems were similar.8 However, anti-VEGF therapy is not a panacea for ROP; reactivation or delayed progression of peripheral retina vascularisation may occur after injection.9 Therefore, recent ROP treatment guidelines from The Royal College of Ophthalmologists recommend close monitoring after anti-VEGF injection therapy.10
 
This new paradigm of ROP treatment requires an update to the classification of ROP. The International Classification of ROP, Third Edition (ICROP3) refined classification metrics such as posterior zone II, notch, and subcategorisation of stage 5; it also recognised the existence of a continuous spectrum of vascular abnormalities (ie, from normal to plus disease).11 The term ‘aggressive ROP’ replaced the term ‘aggressive-posterior ROP’ because of increasing awareness of aggressive ROP onset in larger infants, which extends beyond the posterior retina in regions of limited resources.
 
Modern advances in neonatal care have greatly improved premature infant survival. However, this improvement has led to an increase in ROP incidence, especially in middle-income countries (eg, India and China).12 In less developed countries or remote areas, telemedicine is increasingly important for ROP screening. Fundus photographs can be taken by nurses or technicians; screening can then be conducted remotely by ophthalmologists who specialise in ROP. This approach avoids the physical stress and financial cost involved in transporting high-risk infants; it also minimises screening delays. The Stanford University Network for Diagnosis of ROP (SUNDROP), a telemedicine-based screening initiative covering six satellite neonatal intensive care units in northern California of the United States (US), has screened 608 infants over 6 years. Its screening sensitivity of 100% and specificity of 99.8% are comparable with bedside clinical examination.13 Furthermore, the use of deep learning and federated learning for automatic diagnosis of ROP is under extensive investigation and may be important in future clinical management.14 15 Technical, medicolegal, regulatory, and financial aspects require consideration.
 
Local investigators have provided valuable data regarding the incidence and visual outcomes of ROP in Hong Kong. From 2007 to 2012, the incidences of ROP and type 1 ROP were 18.5% and 3.7%, respectively, among 513 infants at Caritas Medical Centre.16 Incidences were similar at Queen Mary Hospital in 2013 (16.9% and 3.4%, respectively).17 However, incidences at Prince of Wales Hospital were higher (31% and 4.5%, respectively) among 754 infants from 2007 to 2012.18 This discrepancy may be related to an increase in premature infant survival.18 In a study of 14 infants with type 1 ROP, one (7%) developed retinal detachment, nine (64%) developed amblyopia, and nine (64%) developed strabismus.19
 
Because ROP is a leading preventable cause of childhood blindness, screening protocol adherence is essential. The 2022 United Kingdom (UK) ROP screening protocol recommends examination of all infants born at gestational age (GA) ≤31 weeks and 6 days or with BW <1501 g.20 These thresholds differ from the US screening protocol (GA ≤30 weeks and 0 days or BW ≤1500 g).21 Because of the GA difference, fewer infants would be screened using the US protocol. This modified screening approach would reduce stress on premature infants, limit systemic absorption of dilating eye drops, and eventually lower medical costs. Currently, most hospitals under the Hospital Authority follow the UK protocol.
 
In this issue of the Hong Kong Medical Journal, Iu et al22 evaluated whether the use of the US protocol could reduce the number of infants screened without compromising the type 1 ROP detection sensitivity. The authors reviewed the clinical records of premature infants screened at Prince of Wales Hospital from 2009 to 2018; they found that if the US protocol had been followed, the number of infants requiring screened would have decreased by 21.1%. Using the US protocol, the investigators found that only 1.7% of cases would have been missed; all missed cases would have been mild ROP that did not require treatment.
 
However, conventional screening protocols have their own limitations, primarily because they are solely based on GA and BW. Many potentially unnecessary examinations are conducted to identify the approximately 20% of infants requiring treatment. To avoid unnecessary examinations, investigators are developing new screening algorithms with multiple clinical parameters (eg, postnatal weight gain and hydrocephalus status). Examples of these screening algorithms include WINROP, PINT-ROP, CHOP ROP, ROPScore, CO-ROP, OMA-ROP, G-ROP, STEP-ROP, and DIGIROP.23 24 Various studies are underway to validate these new algorithms. The G-ROP criteria appear promising; they demonstrated greater sensitivity and specificity than the US protocol for US infants.25 Although there is emerging evidence that up to 50% of eye examinations may be avoidable, it remains challenging to utilise the new screening algorithms in Hong Kong; postnatal weight gain is required to calculate these scores, and such data may not be readily available in our region. Until these new screening algorithms are satisfactorily validated, they are unlikely to replace conventional screening criteria. However, now may be the best time for neonatologists and ophthalmologists in Hong Kong to begin preparing for the new era of ROP by updating classification, screening, and treatment protocols.
 
Author contributions
All authors contributed to the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
The authors have declared no conflicts of interest.
 
References
1. Terry TL. Fibroblastic overgrowth of persistent tunica vasculosa lentis in infants born prematurely: II. Report of cases—clinical aspects. Trans Am Ophthalmol Soc 1942;40:262-84.Crossref
2. Shah PK, Prabhu V, Karandikar SS, Ranjan R, Narendran V, Kalpana N. Retinopathy of prematurity: past, present and future. World J Clin Pediatr 2016;5:35-46. Crossref
3. Saugstad OD. Oxygen and retinopathy of prematurity. J Perinatol 2006;26 Suppl 1:S46-50. Crossref
4. Palmer EA. Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP). Doc Ophthalmol 1990;74:245-51. Crossref
5. Munro M, Maidana DE, Chan RV. Raising the bar in retinopathy of prematurity treatment. Can J Ophthalmol 2021;56:149-50. Crossref
6. Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 2011;364:603-15. Crossref
7. Stahl A, Lepore D, Fielder A, et al. Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial. Lancet 2019;394:1551-9. Crossref
8. Marlow N, Stahl A, Lepore D, et al. 2-year outcomes of ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW extension study): prospective follow-up of an open label, randomised controlled trial. Lancet Child Adolesc Health 2021;5:698-707. Crossref
9. Chan JJ, Lam CP, Kwok MK, et al. Risk of recurrence of retinopathy of prematurity after initial intravitreal ranibizumab therapy. Sci Rep 2016;6:27082. Crossref
10. The Royal College of Ophthalmologists. Clinical Guidelines. Treating Retinopathy of Prematurity in the UK. 2022. Available from: https://www.rcophth.ac.uk/wp-content/uploads/2022/03/Treating-Retinopathy-of-Prematurity-in-the-UK-Guideline.pdf. Accessed 3 Jul 2023.
11. Chiang MF, Quinn GE, Fielder AR, et al. International Classification of Retinopathy of Prematurity, Third Edition. Ophthalmology 2021;128:e51-68.
12. Shah PK, Ramya A, Narendran V. Telemedicine for ROP. Asia Pac J Ophthal (Phila) 2018;7:52-5.
13. Wang SK, Callaway NF, Wallenstein MB, Henderson MT, Leng T, Moshfeghi DM. SUNDROP: six years of screening for retinopathy of prematurity with telemedicine. Can J Ophthalmol 2015;50:101-6. Crossref
14. Gensure RH, Chiang MF, Campbell JP. Artificial intelligence for retinopathy of prematurity. Curr Opin Ophthalmol 2020;31:312-7. Crossref
15. Lu C, Hanif A, Singh P, et al. Federated learning for multicenter collaboration in ophthalmology: improving classification performance in retinopathy of prematurity. Ophthalmol Retina 2022;6:657-63. Crossref
16. Yau GS, Lee JW, Tam VT, et al. Incidence and risk factors of retinopathy of prematurity from 2 neonatal intensive care units in a Hong Kong Chinese population. Asia Pac J Ophthalmol (Phila) 2016;5:185-91. Crossref
17. Iu LP, Lai CH, Fan MC, Wong IY, Lai JS. Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong. Hong Kong Med J 2017;23:41-7. Crossref
18. Chow PP, Yip WW, Ho M, Lok JY, Lau HH, Young AL. Trends in the incidence of retinopathy of prematurity over a 10-year period. Int Ophthalmol 2019;39:903-9. Crossref
19. Lok JY, Yip WW, Luk AS, Chin JK, Lau HH, Young AL. Visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated type 1 retinopathy of prematurity (ROP): a 6-year retrospective review in a tertiary centre in Hong Kong. Int Ophthalmol 2018;38:163-9. Crossref
20. Royal College of Paediatrics and Child Health. UK Screening of Retinopathy of Prematurity Guideline. 2022. Available from: https://www.rcpch.ac.uk/sites/default/files/2022-12/FC61116_Retinopathy_Guidelines_14.12.22.pdf. Accessed 3 Jul 2023.
21. Fierson WM; American Academy of Pediatrics Section on Ophthalmology; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2018;142:e20183061. Crossref
22. Iu LP, Yip WW, Lok JY, et al. Comparison of United Kingdom and United States screening criteria for detecting retinopathy of prematurity in Hong Kong. Hong Kong Med J 2023;29:330-6. Crossref
23. Iu LP, Yip WW, Lok JY, et al. Prediction model to predict type 1 retinopathy of prematurity using gestational age and birth weight (PW-ROP). Br J Ophthalmol 2023;107:1007-11. Crossref
24. Lundgren P, Stoltz Sjöström E, Domellöf M, et al. WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants. PLoS One 2013;8:e73256. Crossref
25. Binenbaum G, Tomlinson LA, de Alba Campomanes AG, et al. Validation of the postnatal growth and retinopathy of prematurity screening criteria. JAMA Ophthalmol 2020;138:31-7. Crossref

‘Ten Years Down the Line’: a roundtable on the progress and advancement of medical education and training

Hong Kong Med J 2023 Jun;29(3):195–7 | Epub 8 Jun 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
‘Ten Years Down the Line’: a roundtable on the progress and advancement of medical education and training
Paul BS Lai, MB, ChB (CUHK), MD (CUHK); Gordon TC Wong, MB, BS (Sydney), MD (HKU); Samuel YS Wong, MD (U of Toronto), FHKAM (Family Medicine)
Co-Chairmen, Organising Committee, Tripartite Medical Education Conference 2023, Hong Kong SAR, China
 
Corresponding author: Prof Paul BS Lai (paullai@surgery.cuhk.edu.hk)
This editorial provides a concise summary of the roundtable titled ‘Ten Years Down the Line’ at the Tripartite Medical Education Conference on 14 January 2023 co-organised by the Hong Kong Academy of Medicine, Faculty of Medicine of The Chinese University of Hong Kong, and Li Ka Shing Faculty of Medicine of The University of Hong Kong, Hong Kong SAR, China.
 
 Full paper in PDF
 
 
In 2023, the first-ever Tripartite Medical Education Conference, with the theme ‘Actualising the Curriculum Continuum’, gathered medical experts from Hong Kong and other countries to share their experience and insights regarding medical education. The 2-day conference, held from 14 to 15 January 2023, comprised plenary sessions, symposia, debate sessions, and workshops; one of the main events was a roundtable discussion titled ‘Ten Years Down the Line’ held on 14 January 2023. In this roundtable discussion chaired by Prof Paul Bo-san Lai, four speakers—Prof Gilberto Ka-kit Leung, President of the Hong Kong Academy of Medicine; Prof Francis Ka-leung Chan, Dean, Faculty of Medicine, The Chinese University of Hong Kong; Dr Pamela Pui-wah Lee, Assistant Dean (Clinical Curriculum), Faculty of Medicine of The University of Hong Kong; and Dr Tony Pat-sing Ko, Chief Executive of the Hospital Authority—joined together to discuss medical education, specialty training, workforce planning, and other important topics.
 
Prof Chan highlighted the perceived threats to young doctors in Hong Kong, including a shortage of medical professionals, a potential influx of mainland doctors, and the impact of ‘medical negligence’ cases on morale. He then addressed challenges in medical education and training, including the impacts of population ageing, digital health, and genomic medicine on medical curriculum reform. To address these issues, there have been suggestions that young doctors could be encouraged to remain in the public sector by enhancing their knowledge of artificial intelligence, big data, and genomics; emphasising the clinical and societal impacts of ageing; establishing more exchange programmes; and providing better housing benefits and medicolegal protection. In contrast, Prof Chan stressed the importance of quality assurance to meet the public’s expectations in the future; he noted that, because patients have become better informed, medical knowledge is no longer possessed by healthcare professionals alone. He also stated that role modelling is essential for nurturing, maintaining, and restoring compassion in young doctors.
 
Dr Ko expressed concern about the demographic shift that will lead to a larger population of older adults in the next 10 to 20 years, with fewer young people to care for those older adults. On a more positive note, he observed that young doctors have a longer life expectancy, can easily adapt to new technologies and changes, and can develop innovative ideas; in contrast, senior doctors have more clinical practice experience. Therefore, senior doctors and young doctors can benefit from each other’s knowledge and experience. Furthermore, Dr Ko highlighted the need for confidence in the next generation of doctors, as well as the Hong Kong healthcare system, despite challenges such as population ageing and workforce shortages. For instance, it would have been difficult to predict that the coronavirus disease 2019 pandemic would contribute to the adoption of new healthcare technologies such as telemedicine, which is increasingly convenient and accessible. He stated that it is time to reconsider the medical practice model, shifting its focus away from hospitals, inpatients, and subspecialisation, then reorienting towards primary and integrated care approaches. Although skills and technology are important, he noted that the well-being of young doctors is essential. Young doctors, who are expected to have longer careers because of increased life expectancy, require assistance with managing various risks and adverse events; they also need guidance that helps to build resilience. Concerns about work-life balance among young doctors (eg, gap years or part-time work) require further analysis. He favoured training focused on stress reduction, mindfulness, and research skills, which can facilitate career planning and job matching. He concluded by emphasising the importance of collaboration among senior doctors, trainers, and students, echoing Prof Chan’s view that young doctors should be nurtured by role models.
 
Dr Lee stated that connectivity and convergence are the main trends that will shape healthcare delivery and training in the next decade; the hyperconnected world of big data and artificial intelligence will have the greatest transformative influence on medicine and the patient experience by helping patients to access health data that allows them to become more informed and proactive. The convergence of data modalities (eg, genomics and electronic health records) could facilitate the hospital-at-home concept, thereby decentralising healthcare from hospitals to community locations. As family medicine evolves to focus on comprehensive health and preventive care, there may be a reduced need for subspecialists to manage advanced diseases; in the future, more medical students may pursue primary and preventive care avenues. Consistent with her focus on preparing graduates for postgraduate training and specialisation in the changing healthcare environment over the next 5 to 10 years, Dr Lee presented the redesigned and reformed curriculum of the medical school of The University of Hong Kong that reinforces core competencies for professional practice, thereby strengthening concepts of primary care, preventive medicine, and systems-based practice. A key aspect of the curriculum, the 140+ CORE programme (in combination with point-of-care gadgets and the Internet of Things) contextualises the curriculum into common situations, ordinary clinical settings, relevant knowledge, and appropriate skills and behaviour; it also covers essential considerations of competent and ethical professional practice, avoiding excessive subspecialisation in the early stages of medical training. The redesigned curriculum is informatics-driven and personalised, with support from tools such as Moodle and curriculum maps; learning opportunities are recorded in e-portfolios. Although the digital health revolution is transforming medical care and training, Dr Lee emphasised the continuing need for humanistic aspects of medicine, including empathy and connectedness, which require collaboration between medical schools and healthcare professionals.
 
Prof Leung called for improved communication and collaboration among medical schools, the Hospital Authority, and the Academy to support the ‘continuum’ of medical education and training in Hong Kong. Although specialisation can be beneficial, excessive subspecialisation in healthcare may lead to a shortage of generalists and fragmented care, where patients with multiple diseases are treated by multiple specialists. He argued that although the development of primary care is important, this approach may not resolve the problem of excessive specialisation in the public sector. The Government’s proposed solution of mandatory service can be incorporated before specialist training, but it is challenging to train generalists because medical knowledge is rapidly expanding. To address this challenge, Prof Leung advocated for combined efforts involving medical schools and the Academy to provide doctors with sufficient general knowledge. The Academy is organising a strategic workshop to address these issues, with the goal of establishing a pathway for development over the next 5 to 10 years. He concluded by asserting that future doctors must have greater versatility, a wider knowledge base, and multiple skill sets; these aspects can be facilitated by collaborative efforts among medical schools, the Academy, and the Hospital Authority to maintain institutions and improve communication in a timely manner.
 
Regarding medical student selection criteria, Dr Lee emphasised the importance of passion: the ability to connect with people and demonstrate empathy is a requirement for trainee doctors and medical students. Prof Chan agreed with Dr Lee’s view that strong academic ability is not necessarily an indicator of whether an individual will become a good doctor; teachers must help students to become the right doctors for their patients. With respect to clinical training, Dr Ko noted that medical students should receive early education to ensure an appropriate attitude towards the medical profession.
 
Although Prof Leung generally supported the notion of requiring trainee doctors to teach medical students, he stated that the implementation methods and teaching criteria should be carefully considered. Prof Chan observed that some doctors may be enthusiastic about teaching, whereas others may be reluctant. Prof Leung commented that teaching should be regarded as an opportunity for trainee doctors to practise and improve their clinical skills, rather than a job-related obligation. Dr Ko also emphasised the importance of service, teaching, and research in patient care because an individual’s knowledge comprehension can be improved when they teach others. Dr Lee stated that it is challenging for trainee doctors to accommodate additional time commitments. Instead of teaching, she recommended that—after they have gained sufficient background knowledge—students learn from teachers in an authentic clinical setting.
 
Prof Lai recognised efforts made by both medical schools, the Hospital Authority, and the Academy to address resilience and well-being among young doctors, despite the burnout reported by some of those doctors. Prof Leung stated that it remains challenging to measure resilience, but he agreed that well-being programmes should continue and timely progress monitoring should be explored. Dr Lee highlighted the importance of welcoming and including colleagues and students with diverse personalities, which can facilitate adaptation to various learning and personal needs upon entry into the medical profession. Dr Ko agreed that the demanding and stressful nature of modern clinical practice has increased the need for resilience; thus, young doctors should receive psychological support, crisis management training, and character building guidance throughout their careers. Prof Chan acknowledged that the next generation of doctors will experience substantial new challenges and difficult realities that require resilience. Prof Leung mentioned that there is a difference between helping someone to overcome adversity and allowing them to entirely avoid it; an avoidance approach does not encourage resilience.
 
At the conclusion of the roundtable discussion, Prof Lai stated that young and future doctors are fortunate because major stakeholders are proactively addressing the issues and challenges they are likely to encounter; thus, young and future doctors will be better prepared for their roles and able to provide more effective patient care.
 
Author contributions
The authors were responsible for drafting of the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
Conflicts of interest
All authors have disclosed no conflicts of interest.
 

Reforming education and pedagogy in medicine and health with digital innovations to enhance learning practices and outcomes

© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Reforming education and pedagogy in medicine and health with digital innovations to enhance learning practices and outcomes
Harry HX Wang, PhD1,2,3 #; Yu-ting Li, MPH4 #; Haifeng Zhang, MD5; Ji-bin Li, PhD6; Wenyong Huang, MD4; Martin CS Wong, MD, MPH7,8,9
1 School of Public Health, Sun Yat-Sen University, Guangzhou, China
2 Department of General Practice, The Second Hospital of Hebei Medical University, Shijiazhuang, China
3 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
4 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China
5 Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
6 Department of Clinical Research, Sun Yat-Sen University Cancer Center, Guangzhou, China
7 Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
8 Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
9 Editor-in-Chief, Hong Kong Medical Journal
# Equal contribution
 
Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
 
 Full paper in PDF
 
Countries around the world are experiencing widespread challenges in health workforce expansion to manage the health implications of dramatic changes in demographic, socio-economic, epidemiological, climatic, and technological factors. These changes require health providers to demonstrate increasing flexibility and creativity, along with a more proactive approach in terms of addressing the interactions among diverse factors associated with health and healthcare in an ever-changing environment.1 However, traditional didactic methodologies have been widely utilised to emphasise the central role of the teacher in knowledge transfer and learning practices mainly via planned lectures with large amounts of theoretical content in a fixed environment. This approach offers limited opportunities for students to practise and share their knowledge, hindering the development of adaptability to meet the growing demand for lifelong learning.
 
In this issue of the Hong Kong Medical Journal, Ng et al2 evaluated the effectiveness of online micromodule teaching in knowledge transfer within the urology subspecialty among medical students without prior exposure to urology practice. The ‘flipped classroom’ demonstrated similar efficacy in knowledge transfer, as measured by pre-intervention and post-intervention multiple-choice questions and objective structured clinical examinations, compared with the traditional didactic lecture model.2 The findings suggest that the adoption of micromodules as a ‘flipped classroom’ component can maximise time for practical training and experience sharing between clinicians and medical students. This approach incorporating the use of digital media echoes previous research which highlighted the need for urology training innovation because of the impact of the COVID-19 (coronavirus disease 2019) pandemic.3 Despite the non-inferiority trial design used in their study, the efforts by Ng et al2 to create a culture of autonomy and establish a self-paced learning environment have demonstrated the substantial potential of online digital learning for improving student engagement and sustaining knowledge development.
 
In healthcare and clinical practice, knowledge acquisition is particularly important for both health professionals and the general population. Recent studies have identified widening gaps in health knowledge, awareness, and practice in the fields of hepatology and nephrology.4 5 Additionally, diverse educational resources for health advocacy and self-learning have become available because of the growing popularity of electronic material, combined with increasing access to digital technologies and social media platforms.5 The expansion of internet-based channels has led to broader education outreach, as reflected in a large-scale survey among >3000 respondents who reported regular access to digital platforms for rapid communication of health-related information.6
 
The World Health Organization has identified five key domains for interventions to transform and enhance the education available to health professionals: education and training institutions, accreditation and regulation, financing, monitoring and evaluation, and governance.7 Online learning (e-learning) has been highlighted as an innovative teaching and learning strategy that can support the establishment of institutions with sufficient strength to produce the desired quantity and quality of health professionals in both high-income and resource-limited settings.7 The ‘flipped classroom’ model is gaining popularity as an innovative teaching technique. In contrast to the primarily passive listening approach involved in traditional direct-instruction classroom lectures, students in ‘flipped classrooms’ receive digital learning material (eg, pre-recorded video lectures, podcasts, narrated presentations, and other internet-based material) prior to the traditional in-class session. This approach permits ‘in-class’ time to be used for knowledge consolidation and application through student-centred learning activities such as group discussion, peer projects, problem-solving exercises, and individualised assessments of student understanding. A literature review identified the many opportunities presented by digital technologies, which include (but are not limited to) more effective use of traditional ‘class’ time, greater diversity of learning materials, and additional opportunities to revitalise the learning process.8 For example, the integration of virtual patients and clinical simulation scenarios offers students unique learning opportunities to consolidate practical skills via digitally enhanced clinical practice.8 9 This approach may be ideal for the reformation of medical school curricula to address social stigma associated with various diseases (eg, human immunodeficiency virus/acquired immunodeficiency syndrome,10 mental illness, and cancer11) by incorporating interventions that involve experiential and affective teaching components.
 
The inclusion of digital innovations in education and pedagogy reform enhances clinical competencies among students, while creating environments for resilience building. There is a need to manage physicians’ increasing clinical responsibilities that arise from rapid progress in health systems, in addition to the growing demand for medical and translational research conducted in clinical settings.12 Longer working hours can lead to significant work-life imbalance and greater risks of dissatisfaction and depression among physicians. A territory-wide survey revealed a high prevalence of burnout among training and practising physicians in Hong Kong.13 In the United States, the implementation of an innovative ‘flipped classroom’ mindfulness training programme significantly reduced physician burnout, emotional exhaustion, and depersonalisation among both residents and faculty.14 The design of online modules focused on mind-body skills training, combined with interactive discussion sessions, has demonstrated efficacy in terms of increasing resilience, thereby improving the provision of calm and compassionate care.14
 
Among the various innovative components of the ‘flipped classroom’ model, multimedia tools with digital elements contribute to greater improvements in visualisation and student engagement throughout the teaching and learning process.15 A combination of interactive text, graphics, sound, animation, and video delivered by electronic means may be appropriate for children with intellectual disabilities—such children have an increased risk of infection because their limited cognitive ability hinders absorption and retention of health knowledge.16 A study conducted in Hong Kong showed that the development of multimedia visualisation teaching strategies with visual prompts (eg, lyrics and posters) helped the target population to learn proper hand-washing procedures.16
 
From the perspective of health communication, health awareness among patients (who are enhanced through effective physician-patient education) and clinical skills among physicians have equal importance in terms of ensuring excellent care.17 With respect to eye health, a sustained school-family partnership is critical for achieving the desired goal of ‘Vision for Everyone’.18 Advances in digital communication to share, disseminate, and amplify health messages—to target audiences and the wider community—have key roles in promoting universal eye health and preventing avoidable blindness. Digital technologies are also expected to play major roles in out-of-class settings where the communication of health knowledge between school teachers and students’ parents via digital routes (eg, instant messengers) may have long-term effects on students’ abilities to learn and maintain healthy behaviours.19
 
In recent decades, dramatic advances in digital technologies (eg, mobile computing, artificial intelligence, blockchain, virtual reality, and augmented reality) have facilitated widespread exploration of digital innovations in clinical practice and public health.20 Digitally enhanced learning has become a key driver of health system changes that can empower patients, physicians, and students. Therefore, the expansion of digitally enhanced learning practices should be encouraged and supported, both within and across medical specialities, to generate evidence that can guide education and pedagogy reform in response to the changing environment and health profiles in the post–COVID-19 era.
 
Author contributions
All authors contributed to the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
The authors have declared no conflict of interest.
 
References
1. Gill D, Whitehead C, Wondimagegn D. Challenges to medical education at a time of physical distancing. Lancet 2020;396:77-9. Crossref
2. Ng CF, Lim K, Yee CH, Chiu PK, Teoh JY, Lai FP. Time for change? Feasibility of introducing micromodules into medical student education: a randomised controlled trial. Hong Kong Med J 2023;29:208-13. Crossref
3. Yee CH, Wong HF, Tam MH, et al. Effect of SARS and COVID-19 outbreaks on urology practice and training. Hong Kong Med J 2021;27:258-65. Crossref
4. Chan HL, Wong GL, Wong VW, Wong MC, Chan CY, Singh S. Questionnaire survey on knowledge, attitudes, and behaviour towards viral hepatitis among the Hong Kong public. Hong Kong Med J 2022;28:45-53. Crossref
5. Langham RG, Kalantar-Zadeh K, Bonner A, et al. Kidney health for all: bridging the gap in kidney health education and literacy. Am J Nephrol 2022;53:87-95. Crossref
6. Tam VC, Tam SY, Khaw ML, Law HK, Chan CP, Lee SW. Behavioural insights and attitudes on community masking during the initial spread of COVID-19 in Hong Kong. Hong Kong Med J 2021;27:106-12. Crossref
7. World Health Organization. Transforming and Scaling Up Health Professionals’ Education and Training: World Health Organization Guidelines 2013. Geneva: World Health Organization; 2013.
8. Forde C, OBrien A. A literature review of barriers and opportunities presented by digitally enhanced practical skill teaching and learning in health science education. Med Educ Online 2022;27:2068210. Crossref
9. Kononowicz AA, Woodham LA, Edelbring S, et al. Virtual patient simulations in health professions education: systematic review and meta-analysis by the Digital Health Education Collaboration. J Med Internet Res 2019;21:e14676. Crossref
10. Tam G, Wong NS, Lee SS. Serial surveys of Hong Kong medical students regarding attitudes towards HIV/AIDS from 2007 to 2017. Hong Kong Med J 2022;28:223-9. Crossref
11. Cheung YT, Yang LS, Ma JC, et al. Health behaviour practices and expectations for a local cancer survivorship programme: a cross-sectional study of survivors of childhood cancer in Hong Kong. Hong Kong Med J 2022;28:33-44. Crossref
12. Wang HH, Chen L, Ding H, Huang J, Wong MC. Scientific research on COVID-19 conducted in Hong Kong in 2020. Hong Kong Med J 2021;27:244-6. Crossref
13. Kwan KY, Chan LW, Cheng PW, Leung GK, Lau CS. Burnout and well-being in young doctors in Hong Kong: a territory-wide cross-sectional survey. Hong Kong Med J 2021;27:330-7. Crossref
14. Moffatt-Bruce SD, Nguyen MC, Steinberg B, Holliday S, Klatt M. Interventions to reduce burnout and improve resilience: impact on a health system’s outcomes. Clin Obstet Gynecol 2019;62:432-3. Crossref
15. Abdulrahaman MD, Faruk N, Oloyede AA, et al. Multimedia tools in the teaching and learning processes: a systematic review. Heliyon 2020;6:e05312. Crossref
16. Lee RL, Leung C, Chen H, Tong WK, Lee PH. Five-step hand hygiene programme for students with mild intellectual disability: abridged secondary publication. Hong Kong Med J 2022;28 Suppl 3:41-2.
17. Wang HH, Li YT, Wong MC. Leveraging the power of health communication: messaging matters not only in clinical practice but also in public health. Hong Kong Med J 2022;28:103-5. Crossref
18. Du K, Huang J, Guan H, Zhao J, Zhang Y, Shi Y. Teacher-to-parent communication and vision care-seeking behaviour among primary school students. Hong Kong Med J 2022;28:152-60. Crossref
19. Burton MJ, Ramke J, Marques AP, et al. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020. Lancet Glob Health 2021;9:e489-551. Crossref
20. Budd J, Miller BS, Manning EM, et al. Digital technologies in the public-health response to COVID-19. Nat Med 2020;26:1183-92. Crossref

Postgraduate medical education: see one, do one, teach one…and what else?

Hong Kong Med J 2023 Apr;29(2):104.e1–9 | Epub 14 Apr 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Postgraduate medical education: see one, do one, teach one…and what else?
HY So, FCICM, FHKAM (Anaesthesiology)
Educationist, Hong Kong Academy of Medicine, Hong Kong SAR, China
 
This editorial is based on the Halnan Lecture, which was presented at the Tripartite Medical Education Conference on 15 January 2023 by Dr HY So, Educationist, Hong Kong Academy of Medicine.
 
Corresponding author: Dr HY So (sohy@ha.org.hk)
 
 Full paper in PDF
 
Abstract
Postgraduate medical education (PGME) faces many challenges and must evolve. Three principles can guide this evolution. First, PGME apprenticeship, a form of situated learning, is guided by the four dimensions of the Cognitive Apprenticeship Model: content, method, sequence, and sociology. Second, situated learning involves experiential learning and inquiry processes; it is most effective for learners practicing self-directed learning. The promotion of self-directed learning requires consideration of its three dimensions: process, person, and context. Finally, the need for competency-based PGME can be accomplished through holistic models, such as situated learning. The implementation of this evolution should be informed by the characteristics of the new paradigm, inner and outer settings of the organisations, and individuals involved. Implementation encompasses communication to engage stakeholders, training process redesign in accordance with the new paradigm, faculty development to empower and engage involved individuals, and research to enhance the understanding of PGME.
 
 
 
Introduction
Postgraduate medical education (PGME), a mission of the Hong Kong Academy of Medicine (HKAM), is important for the development of competent caring medical practitioners and for efforts to ensure high-quality patient care.1 As the HKAM celebrates its 30th anniversary, there is a need to examine how it must evolve to accommodate changes in the healthcare landscape, diverse patient needs, the increasing complexity of medical practice, and advances in educational practices.2 Despite the limited evidence available regarding PGME, some principles can guide the necessary evolution. Here, I focus on three themes: (1) PGME is situated learning, (2) PGME should be self-directed, and (3) PGME should be competency-based. Considering the space limitations, I provide a broad framework; readers can acquire additional information from relevant articles included in the References.
 
Postgraduate medical education is situated learning
Understanding situated learning
Postgraduate training in medicine mainly occurs in the workplace through participation in clinical tasks. This training approach can be regarded as a process of apprenticeship after a doctor in training enters a particular specialty or ‘community of practice’ (CoP; discussed in detail below).3 The principles of this learning process include increasing learner engagement in the daily work of the community, professional identity formation, and development of the ability to communicate using the community’s language and act according to the community’s norms.4 Thus, learning is embedded in everyday activities and is no longer considered ‘necessarily or directly dependent on pedagogical goals or official agenda’.4 This mode of learning is consistent with the anthropological concept of ‘situated learning’.
 
The notion of ‘situated learning’ emerged from the work of Lave,5 who identified distinct differences between learning in a school setting and learning through everyday activities. In a school setting, education focuses on individual learners; it is dominated by cognitivism (ie, information transmission and processing) and behaviourism (ie, shaping of behaviour via reinforcement and punishment). In this context, knowledge is perceived as an ‘inert, self-sufficient, abstract, self-contained, symbolic substance, which is transferred from the teacher to the learner and becomes stored in the learner’s memory for later use’.6 In contrast, proponents of situated learning theory recognise that learning is the active construction of knowledge through social collaborations and a focus on social relationships and interactions, rather than a focus on individual learners. Thus, they view knowledge as a tool. An individual can possess a tool without being able to use it; use of the tool helps to increase the individual’s understanding of the tool and the relevant context (ie, situation). The specific learning that occurs is a function of three factors in the context where that learning occurs: the people in the context, the ‘tools’ used, and the specific activity itself.6
 
Three decades after Lave published her seminal work, many researchers in health professions education use situated learning theory to guide curriculum design because they recognise its potential advantages.7 Situated learning places learners in realistic settings where socially acquired knowledge is often valued, strategically utilises the learner’s prior knowledge of a particular subject, and (most importantly) increases the likelihood of knowledge application within similar contexts.7 For example, Lave asked adults to determine which of two products in a grocery store was a ‘best buy’. When participants actually went to a grocery store, talked with people in their group, and physically handled various items to compare sizes and shapes, they correctly answered 98% of the math problems involved in the experiment. In contrast, when participants were provided the same math problems in a paper-and-pencil test format, they correctly answered 59% of the math problems.5
 
Cognitive Apprenticeship Model
As a form of apprenticeship, PGME requires teaching methods that differ from school-based learning approaches. ‘See one, do one, teach one’ is the method used in traditional apprenticeships.3 However, the learning of complex subjects, such as PGME, involves components that are not readily observable, as well as complex relationships and interactions among teachers and learners. Thus, Brown et al8 developed a complementary approach to the traditional teaching model, known as the Cognitive Apprenticeship Model (CAM). The CAM focuses on four dimensions that are present in any learning environment: content, methods, sequencing, and sociology (Table 1).9
 

Table 1. Principles for designing cognitive apprenticeship environments9
 
Content
Domain knowledge constitutes the explicit concepts, facts, and procedures associated with an area of expertise; this type of knowledge is usually found in textbooks and lectures. Proponents of situated learning theory and CAM argue that a strong grasp of domain knowledge is necessary but insufficient for experts who seek to solve real-world problems. Such experts must also acquire three types of strategic knowledge: heuristic strategies, control strategies, and learning strategies.9
 
Method
However, strategic knowledge is often tacit; experts may utilise each type of strategic knowledge without conscious awareness of such use. Therefore, apprenticeship teaching methods are designed to provide learners with opportunities to observe, engage in, and discover the strategic knowledge used by experts, within the relevant context. The six teaching methods in CAM can be categorised into three groups. The first three methods—modelling, coaching, and scaffolding—represent the core of traditional apprenticeships. These methods are intended to help students acquire an integrated set of skills through observation (‘see one’) and guided practice (‘do one’). The next two methods—articulation and reflection—are designed to help students focus their observations and gain conscious control of their own problemsolving strategies. The final method—exploration—aims to encourage learner autonomy in terms of implementing expert problem-solving processes and formulating problems.9 I want to emphasise the links between these teaching methods and Kolb’s Cycle of Experiential Learning. Situated learning constitutes experiential learning via participation in clinical tasks. Kolb10 described experiential learning as a transformative process. When learners perform or ‘do’ a clinical task, they transform abstract knowledge into concrete experience. However, learning is only complete when learners reflect on their concrete experience, then transform that experience back into generalised and abstract knowledge to guide future practice.10 When they are ready, learners can independently apply this enhanced knowledge in practice. Kolb’s Cycle supports the purpose of each group of teaching methods in CAM; it also highlights the value of facilitated reflection and feedback in workplace-based learning, including workplace-based assessment.11
 
Sequencing
The sequence in which clinical tasks are performed affects learning efficacy. Cognitive Apprenticeship Model offers three principles to guide sequencing. First, tasks should progress from simple to complex, requiring increasing amounts of skill and conceptual knowledge. Next, diversity should gradually increase to allow learners to identify conditions in which they should use various skills and strategies. Finally, activities and tasks should progress from a global perspective to a local perspective; thus, learners should build a conceptual map of an activity before considering its details (ie, specific tasks). The establishment of a clear conceptual model of the overall activity helps learners understand the part they are performing, which improves their ability to engage in progress monitoring and develop self-correction skills.9
 
Sociology
Lastly, the social characteristics of learning environments (ie, ‘sociology’) can affect motivation, confidence, and orientation towards problems that individuals encounter as they learn. The first element of sociology, which is a core consideration, is ensuring that learners perform tasks and solve problems in an environment that reflects the real-world nature of such tasks. The second element of sociology is intrinsic motivation. Learning environments should be created in manner that enables learners to perform tasks because the tasks are intrinsically related to their goals of interest, rather than because the tasks are driven by extrinsic motivation (eg, earning a good grade or pleasing the teacher). The third element of sociology is the aforementioned CoP, which comprises a group of people who share a passion for something they do and learn how to do it better during repeated interactions; learning may be an intentional or incidental outcome of those interactions. Communities of practice have three key characteristics: a shared domain of interest; engagement in joint activities, information sharing, and relationship building among members; and the development of a shared repertoire of resources for practice.7 Key components of situated learning are relationships among CoP members and engagement in active communication about skills related to their expertise. Full members of the CoP (ie, specialists) provide guidance to doctors in training; they also learn from each other through these interactions. The final element of sociology is cooperation: learners should work together in a manner that fosters cooperative problem solving. There are many ways in which peer learners can help each other to learn; for example, senior learners can guide junior learners in practice, giving and receiving peer feedback, or solving problems together. Learning via collaboration is a powerful motivator and a powerful mechanism for the expansion of learning resources.9 There is evidence that learners can receive diverse benefits from peer-assisted learning.12 Thus, it is important to empower doctors in training via teaching and feedback, rather than waiting until their specialty training is completed.
 
Implementation considerations
I will use the Consolidated Framework for Implementation Research (CFIR) model to guide this portion of the discussion (Fig).13 14 The CFIR, a conceptual model for implementing change or intervention, consists of five domains. The implementation process, one of the domains, should be informed by considerations of the other four domains: characteristics of the ‘intervention’, inner setting, outer settings, and individuals involved in the intervention.13
 

Figure. Consolidated Framework for Implementation Research13 14
 
Intervention
In this discussion, the intervention is the new model of learning: CAM. Damschroder et al13 identified multiple intervention characteristics that may influence the difficulty encountered during implementation. Model complexity and resource implications, particularly in terms of workforce, could be key challenges. Stakeholder engagement via communication is essential to highlight the potential benefits of this new mode of learning. Testing on a small scale and exploring adaptation to the Hong Kong context would also facilitate implementation.13
 
Inner setting
The implementation of this new mode of learning must be led by an organisation (eg, a college). Leadership, culture, organisational implementation climate, and relevant experiences may affect the implementation of this paradigm shift14; evaluation and management of these factors are potential challenges. Sharing and collaboration among colleges may be useful strategies.
 
Outer settings
Postgraduate medical education occurs in the clinical setting where challenges can arise from interactions among trainers, doctors in training, the HKAM and colleges, employers, regulators, and patients and the caregivers. Two key challenges in this outer setting are patient safety and the tension between service and training.3 Patient safety concerns have led to a substantial increase in the use of simulation in medical education, based on the rationale that simulated practice accelerates the learning curve while providing a safe environment for skills rehearsal and opportunities to learn from error.3 Simulation should be integrated into postgraduate specialty curricula as a core delivery vehicle to complement workplace-based learning for both individual skill development and interprofessional team-based training.15 The other key issue is that doctors in training and their trainers are both clinic employees; thus, a managed tension exists between service and training, which requires ongoing dialogue among stakeholders to ensure appropriate balance.3
 
Individuals involved
The individuals involved, especially the trainers and doctors in training, are part of the inner setting but regarded as a separate domain under the CFIR. Although PGME is ‘situated’, it does not necessarily indicate that effective methods are used to facilitate situated learning. Most clinical teachers are not trained; they simply use teaching methods that they experienced in schools.16 Therefore, faculty development (discussed in detail below) is essential. Moreover, there has been some discussion regarding colleges in which not many of their specialists are motivated to teach. However, situated learning depends on interactions among CoP members; learning opportunities can only be maximised through the engagement and empowerment of all members. Accordingly, faculty development should not be restricted to a selected group, and the objective of such development should not be limited to the acquisition of teaching skills; it should be oriented towards motivating participants to establish a professional identity in which they serve as a clinical teacher.17 Doctors in training cannot be passive learners in this process. In addition to active participation in clinical tasks, they must actively seek out opportunities (eg, reading medical literature, attending workshops and conferences, and receiving mentorship and guidance from experienced practitioners) to enhance their knowledge and skills, then use those enhancements to improve their clinical expertise. Furthermore, in contrast to the school setting, situated learning is not organised according to a curriculum, especially because clinical encounters are not always predictable. Accordingly, doctors in training must assume responsibility for their own learning.18 However, there is evidence that self-directed learning (SDL) is uncommon among learners in Hong Kong.19 This is the second theme that I will address.
 
Postgraduate medical education should be self-directed
Understanding self-directed learning
The notion that doctors in training must assume responsibility for their own situated learning is essential to the concept of SDL. The origin of SDL is closely linked to adult learning theory.18 Knowles20 defined SDL as a process in which individuals take initiative (with or without assistance from others) to determine their learning needs, formulate goals, identify human and material resources for learning, choose and implement appropriate learning strategies, and evaluate learning outcomes.
 
Self-directed learning also requires a paradigm shift. Traditional teaching (ie, pedagogy) is teacher-directed and focuses on content delivery. A major problem with such an educational process is that learners can become accustomed to habitually reinforced patterns of perception, thinking, judgement, feeling, and behaviour; these patterns may lead to inflexible behaviour and a lack of motivation for SDL.21 The direction of adult learning (ie, andragogy) involves engaging learners in an inquiry process. Based on the six assumptions of adult learning (Table 2), Knowles et al22 described a process which teachers can use to facilitate such inquiry (Table 3). It has been argued that SDL is a universally necessary competency in a changing world, particularly for individuals in complex fields such as medicine.21 Indeed, the Accreditation Council for Graduate Medical Education has recommended that doctors in training become self-directed learners, use innovative tools (eg, computerised diaries and portfolios) to evaluate their own learning, and facilitate learning in other individuals.23
 

Table 2. Assumptions of adult learning22
 

Table 3. An andragogical process model for learning22
 
More recently, Hase and Kenyon24 expanded the concept of SDL and proposed the notion of heutagogy (ie, self-determined learning) as a learning paradigm for the information age. Although the concept is complex, it can be summarised as follows: modern technology enables explorations of existing knowledge, connections with experts, collaborations with peers, reflections on personal experiences, and the creation and sharing of knowledge. This technology makes learning flexible, allowing learners to learn at their preferred time and in their preferred manner.22 Accordingly, e-learning utilising this technology should be viewed as an approach to re-define the learning experience, rather than as a simple substitute for more traditional learning methods.25 This learning paradigm is relevant to PGME and lifelong learning.
 
Dimensions of self-directed learning and implications for implementation
The definition established by Knowles et al22 implies a process to facilitate SDL. However, there is increasing recognition that, in addition to the process component, the construct of SDL has multiple dimensions.18 22 26 Additionally, Ricotta et al26 suggested that the application of SDL in clinical settings would require approaches that differ from classroom methods because of its more rapid pace and the need to consider patient safety. Here, I will address the three dimensions described in two models of SDL in medical education: process, person, and context.18 26
 
Process
As mentioned above, trainers must utilise appropriate strategies to facilitate the inquiry process. In addition to the process described by Knowles et al22 (Table 3), Sawatsky et al18 and Ricotta et al26 described learning processes in SDL; although the three groups of authors used different terminology in their descriptions, all processes are conceptually similar. The fundamental requirements of strategies to facilitate SDL should focus on learner engagement, emphasise curiosity, support inquiry-based approaches, and promote exploration.26
 
Person
Self-directed learning is a question of the extent to which learners maintain active control of the learning process.27 Thus, the use of appropriate facilitation processes is necessary but not sufficient to fulfil the goals of SDL. Learners must thoroughly grasp essential learning skills and develop personal attributes necessary to control the inquiry process. Feedback literacy is a particularly important learning skill because reflection and feedback are indispensable components of experiential learning. Carless28 defined feedback as an interactive process in which students interpret and use various inputs to enhance their work. The utilisation of feedback, combined with engagement in actions that close the feedback loop, is an active process. In his model of feedback literacy, Carless28 established three pre-conditions: appreciation of feedback, formation of judgements, and management of affect. Trainers can help foster feedback literacy through strategies such as peer feedback.
 
The personal attributes of curiosity, perseverance, flexibility, and integrity are prerequisites for individuals who wish to engage in SDL. Motivation is a key factor which energises and connects these attributes.26 The predispositions of doctors in training towards SDL will gradually change as they develop confidence in SDL and gain a more sophisticated knowledge framework.18 Trainers should assess learner readiness and cultivate SDL through the adoption of teaching strategies appropriate for each stage (Table 4).29
 

Table 4. Staged self-directed learning model29
 
Context
The personal attributes described above must be developed in an effective and safe learning environment. Importantly, these attributes may be threatened by approaches that emphasise professional examinations and competition among doctors in training. The cultivation of SDL requires a paradigm shift from a traditionally competitive learning environment to an environment that encourages humility and accepts failure.26 Trainers should establish psychological safety, encourage curiosity, and normalise cognitive dissonance. At the organisational level, a curiosity-focused culture can facilitate learning activities. The acceptance of uncertainty and promotion of inquiry-based approaches help learners to become motivated and prepared to pursue SDL. The creation of an environment that supports SDL development requires new strategies, prioritisation of learner engagement, and encouragement of questioning.26
 
Postgraduate medical education should be competency-based
Understanding competency-based medical education
Building on the above discussion regarding the learning environment and methods necessary for PGME, I will explore the desired outcomes. Although the concept of outcome-based or competency-based education emerged nearly a century ago, its popularisation in medical education began in the 1990s when leaders in the Canadian medical profession observed widespread dissatisfaction in many areas.30 31 They attributed this dissatisfaction to forces such as the availability of medical information on the internet, patient consumerism, government regulations, financial imperatives, litigation, technology, and an overall explosion of medical knowledge; thus, they concluded that medical education could no longer be planned with a focus solely on the latest aspects of medical diagnosis and treatment.31 Modern professional training should create doctors who can accommodate rapid advances in medicine, recognise patient perspectives, appreciate the skills of other health professionals, and work effectively in teams.32 Therefore, training programmes should address clinical skills and knowledge, along with other aspects of clinical competence required among doctors (eg, communication skills, attitude, team working, audit, research, teaching, and SDL).32 The Royal College of Physicians and Surgeons of Canada included seven competencies under the CanMEDS framework.33 34 Similar developments soon followed in other countries.23 35 36 In 2010, the Hong Kong Academy of Medicine published a position statement indicating that the ‘Hong Kong Specialist’ should demonstrate competency in seven broad domains: professional expertise, health promoter, inter-personal communication, team working, academic, manager-leader, and professionalism.37
 
Implementation process
A common approach to teaching multiple competencies involves dividing them into individual units, then teaching them separately using methods that are appropriate for each competency. Among educationists, this is known as the ‘atomistic approach’, which is difficult to implement because the curriculum is already very full. Moreover, this approach is ineffective in situations that involve complex learning because the competencies are closely related to each other and the whole is more than the sum of its parts—it contains the elements and the relationships among those elements.38 A holistic approach using real-world tasks avoids potential problems regarding compartmentalisation and fragmentation.38 In the setting of PGME, situated learning and CAM are appropriate methods. Accordingly, the three themes discussed here are closely linked together and can be regarded as a single paradigm for modern PGME.
 
The implementation process of this new paradigm, one of the five domains of the CFIR (Fig),13 14 consists of four strategies based on implementation research and theories: communication, redesign, faculty development, and research.31
 
Communication
The new paradigm is very different from current practice; it is also complex and involves significant resource investments. Successful implementation heavily relies on effective communication to engage stakeholders in both the inner and outer settings. Frank and Danoff31 suggested the use of a social marketing–based communication plan. The framework of social marketing includes concepts of exchange theory, audience segmentation, competition, consumer orientation, and continuous monitoring.39
 
Redesign
The Academy and the colleges are responsible for setting educational standards for PGME objectives, training programme accreditation, assessment, professional examinations, and continuing medical education standards; thus, they should redesign the relevant educational standards to incorporate a foundation that involves all competencies.31 This integrative approach would include efforts to align curricular objectives with experiential training in the clinical workplace.40 The incorporation of workplace-based assessment into the curriculum is an example of such integration.41
 
Faculty development
Steinert42 defined faculty development as all activities that health professionals pursue to improve their knowledge, skills, and behaviours as teachers and educators, leaders and managers, and researchers and scholars, in both individual and group settings. The engagement and empowerment of all CoP members in teaching and learning are prerequisites for implementing community-based medical education via situated learning. Steinert et al17 recommended that the process of faculty development mirror the process of PGME itself: it should utilise SDL and view learning as a process of inquiry through experiential learning, rather than as a process of direct transmission. It should also utilise situated learning theory and view teaching skills as tools to be used in specific contexts, rather than objects that can be acquired. Thus, although workshops may be a useful starting point, there is a need to focus on longitudinal development via faculty development communities.17 As mentioned above, the objective of faculty development should not be limited to teaching skill acquisition; it should include the establishment of a professional identity as a clinical educator, as well as motivation for teaching.17 Similarly, faculty development should promote a culture of change and further development of PGME through innovation, research, and organisational transformation.17 42
 
Research
Finally, the field of PGME is comparatively new and does not have a strong academic presence. Most of its practical approaches are derived from undergraduate medical education or general education. However, there are some concerns, learning methods, and practices with uniquely ‘postgraduate’ origins.3 Considerable research efforts are necessary to provide evidence that can drive further improvements in PGME, and resources are needed to support such efforts.3 31
 
Conclusion
Health professionals are expected to possess a diverse set of competencies that fulfil current societal needs. Apprenticeships using real-world clinical tasks can provide effective competency-based medical education. However, the traditional ‘see one, do one, teach one’ approach is inadequate for the complex learning tasks involved in PGME. Instead, learning in this environment involves the facilitation of experiential learning and inquiry, rather than simple content delivery. To achieve this shift in perspective, teaching methods from CAM and SDL must be adopted. The cultivation of SDL requires appropriate context, as well as a CoP with members who possess teaching skills and attitudes that differ from traditional teaching. Faculty development is important for the successful implementation of this new paradigm; it should be grounded in the same principles of experiential learning, situated learning, and SDL. This approach will equip members of the CoP with essential skills, while supporting effective communication and engagement. Moreover, it will cultivate the talent necessary to redesign standards and practices, while encouraging interest and active participation in research efforts to advance PGME.
 
Author contributions
The author was solely responsible for drafting of the manuscript, approved the final version for publication, and takes responsibility for its accuracy and integrity.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
Conflicts of interest
The author has disclosed no conflicts of interest.
 
References
1. McLean M, Cilliers F, Van Wyk JM. Faculty development: yesterday, today and tomorrow. Med Teach 2008;30:555-84. Crossref
2. Patel M. Changes to postgraduate medical education in the 21st century. Clin Med (Lond) 2016;16:311-4. Crossref
3. Swanwick T. Postgraduate medical education: the same, but different. Postgrad Med J 2015;91:179-81. Crossref
4. Lave J, Wenger E. Situated Learning: Legitimate Peripheral Participation. Cambridge: Cambridge University Press; 1991. Crossref
5. Lave J. Cognition in Practice: Mind, Mathematics and Culture in Everyday Life. Cambridge: Cambridge University Press; 1988. Crossref
6. Durning SJ, Artino AR. Situativity theory: a perspective on how participants and the environment can interact: AMEE guide no. 52. Med Teach 2011;33:188-99. Crossref
7. O’Brien BC, Battista A. Situated learning theory in health professions education research: a scoping review. Adv Health Sci Educ Theory Pract 2020;25:483-509. Crossref
8. Brown JS, Collins A, Duguid P. Situated cognition and the culture of learning. Educ Res 1989;18:32-42. Crossref
9. Collins A, Kapur M. Cognitive apprenticeship. In: Sawyer RK, editor. The Cambridge Handbook of the Learning Sciences. 2nd ed. Cambridge: Cambridge University Press; 2014:109-27. Crossref
10. Kolb DA. Experiential Learning: Experience as the Source of Learning and Development. Upper Saddle River, NJ: Pearson Education Ltd; 2015.
11. Saedon H, Salleh S, Balakrishnan A, Imray CH, Saedon M. The role of feedback in improving the effectiveness of workplace based assessments: a systematic review. BMC Med Educ 2012;12:25. Crossref
12. Brierley C, Ellis L, Reid ER. Peer-assisted learning in medical education: A systematic review and meta-analysis. Med Educ 2022;56:365-73. Crossref
13. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a Consolidated Framework for advancing implementation science. Implement Sci 2009;4:50. Crossref
14. Carney PA, Crites GE, Miller KH, et al. Building and executing a research agenda toward conducting implementation science in medical education. Med Educ Online 2016;21:32405. Crossref
15. Issenberg SB, Mcgaghie WC, Petrusa ER, Lee Gordon D, Scalese RJ. Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic review. Med Teach 2005;27:10-28. Crossref
16. MacDougall J, Drummond MJ. The development of medical teachers: an enquiry into the learning histories of 10 experienced medical teachers. Med Educ 2005;39:1213-20. Crossref
17. Steinert Y, Mann K, Anderson B, et al. A systematic review of faculty development initiatives designed to enhance teaching effectiveness: a 10-year update: BEME Guide no. 40. Med Teach 2016;38:769-86. Crossref
18. Sawatsky AP, Ratelle JT, Bonnes SL, Egginton JS, Beckman TJ. A model of self-directed learning in internal medicine residency: a qualitative study using grounded theory. BMC Med Educ 2017;17:31. Crossref
19. Frambach JM, Driessen EW, Chan LC, van der Vleuten CP. Rethinking the globalisation of problem-based learning: how culture challenges self-directed learning. Med Educ 2012;46:738-47. Crossref
20. Knowles MS. Self-Directed Learning: A Guide for Learners and Teachers. Chicago: Associated Press; 1975.
21. Morris TH. Self-directed learning: a fundamental competence in a rapidly changing world. Int Rev Educ 2019;65:633-53. Crossref
22. Knowles MS, Holton III EF, Swanson RA. The Adult Learner: The Definitive Classic in Adult Education and Human Resource Development. 5th ed. Woburn, Mass: Butterworth-Heinemann; 2005.
23. Accreditation Council for Graduate Medical Education. Common program requirements. 2022. Available from: https://www.acgme.org/what-we-do/accreditation/common-program-requirements/. Accessed 17 Mar 2023.
24. Hase S, Kenyon C. Self-Determined Learning: Heutagogy in Action. London: Bloomsbury Academic; 2015.
25. Hamilton ER, Rosenberg JM, Akcaoglu M. The Substitution Augmentation Modification Redefinition (SAMR) Model: a critical review and suggestions for its use. TechTrends 2016;60:433-41. Crossref
26. Ricotta DN, Richards JB, Atkins KM, et al. Self-directed learning in medical education: training for a lifetime of discovery. Teach Learn Med 2022;34:530-40. Crossref
27. Loeng S. Self-directed learning: a core concept in adult education. Educ Res Int 2020;2020:3816132. Crossref
28. Carless D. From teacher transmission of information to student feedback literacy: activating the learner role in feedback processes. Act Learn High Educ 2020;23:143-53. Crossref
29. Grow GO. Teaching learners to be self-directed. Adult Educ Q 1991;41:125-49. Crossref
30. Harden RM, Crosby JR, Davis MH. AMEE Guide No. 14: Outcome-based education: Part 1—an introduction to outcome-based education. Med Teach 1999;21:7-14. Crossref
31. Frank JR, Danoff D. The CanMEDS initiative: implementing an outcomes-based framework of physician competencies. Med Teach 2007;29:642-7. Crossref
32. Long G, Gibbon WW. Postgraduate medical education: methodology. Br J Sports Med 2000;34:236-7. Crossref
33. Frank JR. The CanMEDS 2005 Physician Competency Framework. Ottawa: The Royal College of Physicians and Surgeons of Canada; 2005.
34. Snell L, Sherbino J, Frank J. CanMEDS 2015 Physician Competency Framework. Ottawa: Royal College of Physicians and Surgeons of Canada; 2015.
36. The consensus statement on the role of the doctor. Available from: https://www.medschools.ac.uk/media/1922/role-of-the-doctor-consensus-statement.pdf. Accessed 15 Dec 2022.
37. Hong Kong Academy of Medicine Position Paper on Postgraduate Medical Education. 2010. Available from: https://www.hkam.org.hk/sites/default/files/HKAM_position_paper.pdf. Accessed 17 Mar 2023.
38. van Merriėṅboer JJ, Kirschner PA. A new approach to instruction. In: an Merriėṅboer JJ, Kirschner PA, editors. Ten Steps to Complex Learning: A Systematic Approach to Four-Component Instructional Design. New York: Routledge; 2018: 5-8. Crossref
39. Grier S, Bryant CA. Social marketing in public health. Annu Rev Public Health 2005;26:319-39. Crossref
40. Caverzagie KJ, Nousiainen MT, Ferguson PC, et al. Overarching challenges to the implementation of competency-based medical education. Med Teach 2017;39:588-93. Crossref
41. Lockyer J, Carraccio C, Chan MK, et al. Core principles of assessment in competency-based medical education. Med Teach 2017;39:609-16. Crossref
42. Steinert Y. Faculty Development in the Health Professions: A Focus on Research and Practice. Dordrecht: Springer; 2014. Crossref

Key elements of gross negligence manslaughter in the clinical setting

Hong Kong Med J 2023 Apr;29(2):99–101 | Epub 24 Mar 2023
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Key elements of gross negligence manslaughter in the clinical setting
Albert Lee, FHKAM (Family Medicine), LLM
The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
 
Corresponding author: Prof Albert Lee (alee@cuhk.edu.hk)
 
 Full paper in PDF
 
 
Clinical liability arises when a medical practitioner fails to meet the standard of reasonable medical care.1 Most medical malpractice litigation is pursued under the tort of negligence (civil cases). The burden of proof is ‘on the balance of probabilities’ in civil cases. In criminal cases, the burden of proof is ‘beyond reasonable doubt’, and the prosecution bears the burden of proof. Convictions for criminal charges such as gross negligence manslaughter (GNM) require a higher degree of wrongfulness.
 
A recent book chapter highlighted the tension and fears among healthcare professionals with rising the increasing number of high-profile GNM cases, coupled with the perception of arbitrary and inconsistent approaches to GNM investigation and prosecution in the United Kingdom2 resulting in a rapid policy review on GNM in healthcare.3 The review panel emphasised that healthcare professionals could not be, or appear to be, above the law. However, the complexities of modern healthcare and the stressful clinical environment must be taken into consideration when deciding whether to pursue a GNM investigation.
 
In 2018, Leung4 reviewed key medical manslaughter cases from the previous decade: Sellu,5 Bawa-Gaba,6 and DR Group.7 In Sellu,5 the surgeon was held in high regard by his peers and patients, and the penalty was considered unjustifiable and disproportionate. In Bawa-Gaba,6 there was criticism for failing to give due consideration to system factors.8 In DR Group,7 a retrial of one of the defendants, Dr Mak, was ongoing at the time of the 2018 review. The findings of two reviews (by the United Kingdom Government3 and the General Medical Council9) led to a perception among healthcare professionals that the legal tests for GNM were inconsistently applied.2 Thus, there is a need to review the judgements in the retrial of Dr Mak10 and another case involving a doctor convicted of GNM, Dr Kwan,11 in the context of some key historical cases and published literature.
 
Before the retrial of Dr Mak, the defendant doctor appealed on the question of requirement of the prosecution to prove the culpability of the defendant’s state of mind that she was subjectively aware of the obvious and serious risk of death to the deceased.12 The Court of Final Appeal unanimously dismissed the appeal that only application of the objective standard of reasonableness, as referred in the last element of the offence in R v Adomako,13 is needed with no additional requirement to prove the defendant’s subjective aware of an obvious and serious risk of death.12
 
In Adomako,13 an anaesthetist in charge of a patient during eye surgery failed to notice or respond to obvious signs of oxygen tube disconnection, and the patient died. The jury convicted the anaesthetist of GNM. The evidence13 indicated that 4.5 minutes would have elapsed between the disconnection and sounding of the alarm; the anaesthetist responded in various ways but did not check the oxygen tube connection. One expert witness stated that a competent anaesthetist should have recognised the disconnection within 15 seconds because the patient’s blood pressure and pulse had decreased, and the patient’s chest was not moving. Another expert witness described the standard of care as ‘abysmal’ (extremely bad). The anaesthetist’s conviction of GNM was upheld by the House of Lords on appeal.13 Lord Mackay LC set the following tests for a conviction of GNM13:
  • Had the defendant breached the duty of care towards the victim who had died?
  • If yes, whether the breach of duty had caused death?
  • If so, the jury needed to go on to consider whether that breach of duty should be characterised as gross negligence and therefore as a crime.
  • The jury would then have to consider the extent to which the defendant’s conduct departed from the proper standard of care constituting a risk of death to the patient, was such that it should be judged criminal.
  • The jury question was whether the conduct of the defendant was so bad in all the circumstances as to amount in their judgement to a criminal act.
  •  
    There was an argument about circularity because the jury was asked to define whether an offence had been committed; the jury’s task is to determine the facts, then apply the law. Lord Mackay was aware of the element of circularity and he did not believe that it would be fatal as the test being correct to determine how far the conduct should depart from the accepted standard to be characterised as criminal. The judgement of the Court of Final Appeal regarding Dr Mak stated that the test is not circular and there is no abdication of the judge’s role in defining the offence for the jury.12 Juries are assisted by expert evidence when considering difficult questions, and it is not unusual for juries to perform an evaluative function.12 In R v Misra,14 Judge LJ pointed out that the jury would be asked difficult questions, such as whether a defendant had acted dishonestly by reference to the contemporary standard, or when charged on dangerous driving causing death, whether the standard of driving fell far below the standard to be expected as a competent driver.15
     
    In Misra,15 the doctor was convicted of GNM when their patient became infected with Staphylococcus aureus after surgery and did not receive the necessary treatment. The defendant doctor appealed on the basis that the test for gross negligence presented to the jury was circular and unclear. The appeal was dismissed; the jury’s determination of ‘gross negligence’ was regarded as a question of fact, rather than a question of law. The Lord Justice Judge wrote that there was a failure to appreciate the patient’s serious illness, including the classic signs of infection (elevated temperature, rapid pulse, and lowered blood pressure). The mistakes made were elementary.16
     
    In the retrial of Dr Mak,10 the defendant doctor was found guilty of GNM by the jury. The judge was satisfied that the jury must have found the defendant doctor in breach of her duty to the deceased and it was reasonably foreseeable that the breach of that duty giving rise to a serious and obvious risk of death and indeed caused the death. The jury must have also been satisfied that the circumstances of the breach were truly exceptionally bad and so reprehensible to justify criminal punishment.
     
    In Dr Kwan,13 the patient attended for liposuction procedure. The patient was infused with the combination of sedative drugs at the start of the procedure and she was deeply sedated and unconscious. She was attached to the Mindray machine during the procedure and the device alarmed throughout the procedure indicating that there was a problem with patient’s vital signs. The alarm was ignored and silenced each time by one of the assistants. After the completion of the procedure, the defendant doctor left leaving the patients under the care of medically untrained assistants while the patient was still unconscious. The defendant doctor was called back by her assistants when the patient’s condition had deteriorated. The defendant doctor called for help but did not provide resuscitation of basic life support.
     
    The jury’s verdict was that the defendant’s failures fell far below the standard of a competent doctor.13 The inactions and actions of the defendant substantially caused the death of the patient. A reasonably competent doctor would have foreseen that the breach of her duties gave rise to a serious and obvious risk of death and her breach was so truly exceptionally bad and so reprehensible.
     
    In R v Rose,17 the defendant optometrist negligently failed to examine the retinas of a child and thus did not identify papilledema; consequently, hydrocephalus in the child was not diagnosed or treated, and the child died a few months later. The Court of Appeal held that, in failing to examine the eye at all, the optometrist would not have been aware of ‘a serious and obvious risk of death’; thus, Rose was considered simply negligent. Conversely, in R v Winterton,18 the defendant construction manager was convicted of manslaughter when a trench collapsed on a labourer, causing that labourer’s death. The Court of Appeal held that the obvious and serious risk of death caused by the trench should have been apparent to Winterton.
     
    An article by Robson et al19 offers the criticism that current GNM tests are not particularly concerned with the context in which a negative event occurs; they are solely focused on evaluating responsibility for specific acts of misconduct. Importantly, Robson et al19 address the element of culpability necessary for conduct to be considered criminal, particularly with respect to distinguishing errors from violations. Errors constitute instances in which ‘one tries to do the right thing but actually does the wrong thing’; violations constitute instances that involve intentional deviations ‘from those practices deemed necessary to maintain the safe operation of a potentially hazardous system’.20 Robson et al19 argue that a negligent doctor should not be criminally liable for a momentary lapse of concentration or an instance of inattention that involved an error in judgement.
     
    Although current law only applies the objective standard of reasonableness, case law has established the key elements that can be used to determine whether negligent act of medical practitioner would be alleged GNM:
  • gross departure from expected standard of care;
  • ignoring reasonable foreseeable obvious and/or serious risks;
  • failing to take actions to allow the risks continuing to endanger patient’s life;
  • the acts of medical practitioners disregard the life of the patient; and
  • the circumstances of the breach of duty (in Adomako all circumstances were emphasised) should have been truly exceptionally bad, ie, no reasonable doctor would have done.
  •  
    It is important that precise direction is given to jury to consider the facts whether the standard of care has really fallen far below the standard and exceptionally bad taken account of the circumstances. The jury must consider whether the defendant doctor should have been aware of reasonably foreseeable obvious and serious risks, but failed to take action. Recent editorial has highlighted the important role of expert opinion in triggering an investigation and determination of a case for prosecution.21 Juries rely upon high-quality expert opinions when making factual determinations regarding whether a medical practitioner’s conduct constitutes GNM.
     
    A criminal conviction has serious and devastating consequences; thus, many countries (both common law and civil law jurisdictions) uphold the doctrine of ‘Presumption of Innocence’. For GNM in clinical context, the facts must be accurately dissected and assessed by competent experts; each element of the offence must be proven beyond reasonable doubt to support a conviction of GNM.
     
    Author contributions
    The author was solely responsible for drafting of the manuscript, approved the final version for publication, and takes responsibility for its accuracy and integrity.
     
    Funding/support
    This editorial has received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    Declaration
    The author has disclosed no conflicts of interest. The opinions expressed in this article reflect the views of the author, not the institutions with which he is affiliated.
     
    References
    1. Lee A. Clinical liability in Hong Kong: revisiting duty and standard of care. In: Raposo VL, Beran RG, editors. Medical Liability in Asia and Australasia (Ius Gentium: Comparative Perspectives on Law and Justice, 94). Singapore: Springer; 2022: 41-60. Crossref
    2. Lee DW, Tong KW. What constitutes negligence and gross negligence manslaughter? In: Chiu JS, Lee A, Tong KW, editors. Healthcare Law and Ethics: Principles & Practices. Hong Kong: City University of Hong Kong Press; 2023: 112-52.
    3. Department of Health and Social Care, United Kingdom. Gross negligence manslaughter in healthcare. The report of a rapid policy review. Jun 2018. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/717946/Williams_Report.pdf. Accessed 17 Mar 2023.
    4. Leung GK. Medical manslaughter in Hong Kong—how, why, and why not? Hong Kong Med J 2018;24:384-90. Crossref
    5. David Sellu v R. [2016] EWCA Crim 1716
    6. R v Hadiza Bawa-Garba [2016] EWCA Crim 1841
    7. HKSAR v Chow Heung Wing Stephen & Ors [2018] HKCFI 60
    8. Cohen D. Back to blame: the Bawa-Garba case and the patient safety agenda. BMJ 2017;359:j5534. Crossref
    9. General Medical Council. Independent review of gross negligence manslaughter and culpable homicide. 2019. Available from: https://www.gmc-uk.org/-/media/documents/independent-review-of-gross-negligence-manslaughter-and-culpable-homicide---final-report_pd-78716610.pdf. Accessed 22 Feb 2023.
    10. HKSAR v Mak Wan Ling [2020] HKCFI 3069
    11. HKSAR v Dr. Kwan Hau-chi, Vanessa [2021] HCCC 2000/2018, [2021] HKCFI 2978
    12. HKSAR v Mak Wan Ling [2019] HKCFA 37
    13. R v Adomako [1994] 3 WLR 288 House of Lords
    14. R v Misra [2005] 1 Cr App R 21
    15. R v Misra [2005] 1 Cr App R 21 at §63
    16. R v Misra and Srivastava [2005] 1 Cr App R 328
    17. R v Rose [2017] EWCA Crim 1168
    18. R v Winterton (Andrew) [2018] EWCA Crim 2435
    19. Robson M, Maskill J, Brookbanks W. Doctors are aggrieved—should they be? Gross negligence manslaughter and the culpable doctor. J Criminal Law 2020;84:312-40. Crossref
    20. Merry A, Brookbanks W. Violations. In: Merry A, Brookbanks W. Merry and McCall Smith’s Errors, Medicine and the Law. 2nd ed. Cambridge: Cambridge University Press; 2017: 141-82. Crossref
    21. Leung GK. Medical manslaughter in Hong Kong: what now? Hong Kong Med J 2023;29:4-5.Crossref

    Revisiting primary healthcare and looking ahead

    Hong Kong Med J 2023 Apr;29(2):96–8 | Epub 6 Feb 2023
    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    Revisiting primary healthcare and looking ahead
    Harry HX Wang, PhD1,2,3 #; Yu-ting Li, MPH4 #; Yali Zhang, MD2 #; Martin CS Wong, MD, MPH5,6
    1 School of Public Health, Sun Yat-Sen University, Guangzhou, China
    2 Department of General Practice, The Second Hospital of Hebei Medical University, Shijiazhuang, China
    3 Usher Institute, Deanery of Molecular, Genetic and Population Health Sciences, The University of Edinburgh, Scotland, United Kingdom
    4 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China
    5 The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    6 Editor-in-Chief, Hong Kong Medical Journal
    # Equal contribution
     
    Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
     
     Full paper in PDF
     
     
    Primary care physicians worldwide provide a key point of entry to the healthcare system, and are at the forefront of communicating with the community in the context of vaccination campaign and control of infectious diseases.1 2 Primary care plays a fundamental role in building a resilient healthcare system by ensuring people’s continued access to health promotion, disease prevention, essential treatment, long-term rehabilitation, and supportive care.3 Topics relevant to primary healthcare are an increasingly common sight in international medical journals, including Hong Kong Medical Journal (HKMJ).
     
    COVID-19 (coronavirus disease 2019) has presented an unprecedented dual challenge for primary healthcare in recent years, to respond to the public health threat and simultaneously maintain routine delivery of clinical care and preventive services. A health system’s ability to address the ever-growing care complexity is substantially dependent on the accessibility and coordination of primary healthcare. In Singapore, Public Health Preparedness Clinics, an island-wide network of over 900 primary care clinics and polyclinics, served an epidemiological role through the routine collection of data on community transmission by primary care physicians.4 This approach has added to our understanding of how primary healthcare could contribute to enhancing and tightening disease surveillance. In Europe, primary care physicians coordinate care through active participation in knowledge transfer, integration into crisis management teams, and involvement in strategic responses to the pandemic, which is particularly important for fulfilling shared goals to achieve a high level of resilience.5 Other low- and middle-income settings in Asia have also provided examples of how primary care providers are in a privileged position to utilise a variety of resilience mechanisms including mentor support, peer communication, family encouragement, and community recognition.6
     
    In rural China, there are significant disparities in primary care utilisation among different ethnic minority healthcare providers, together with an association between inadequate clinical competency and poor primary care utilisation. Shi et al,7 writing in HKMJ’s ‘Healthcare in Mainland China’, found that in-service training investments and favourable learning environments are required to develop the capacity and capability required for ethnic minority health practitioners. Meanwhile, concerns have been raised over the difficulties in retaining qualified healthcare professionals in deprived rural communities.8 Furthermore, given the possible widening of inequalities in socio-economic determinants of health, people living in more disadvantaged rural areas are more likely to face poor accessibility of healthcare services and suboptimal physician capacity than that in more affluent urbanised areas as a result of the ‘inverse care law’.9 Previous findings suggested that a lack of physician’s continuing medical education may serve as a notable barrier to satisfactory primary care performance in rural areas.10 These challenges highlight the increasing need for system-wide multisectoral collaboration and partnerships with novel tools to enhance physicians’ engagement in context-specific training and care empowerment.11 Alongside efforts to reconfigure primary care teams to address patients’ barriers to following evidence-based regime and advice,12 improved communication skills are crucial not only in clinical practice but also in public health.13 This will underpin a wider landscape of primary healthcare that incorporates population-wide evidence-based approaches to reducing health inequalities in the context of socio-economic diversity.
     
    From a process of care perspective, there is a greater need for strategies to engage multisectoral efforts to strengthen capacity building within, with and around primary care multidisciplinary teams in joint decision-making and problem-solving.14 Practice-level strategies have been identified in a most recent review of international literature which summarised new approaches to ensure the continuity of regular care provision during the pandemic.15 A novel strategy has been characterised by the integration of digital health (or eHealth) services into practice. These services, which can be delivered via telephone, video consultations, email, text messaging, online portals, or smartphone applications, provide an opportunity to expand seamless access to health services for people in remote areas, and also allow rapid exchange of health information. This enables primary care multidisciplinary teams to respond precisely to specific situations of individuals. With the escalating popularity of wearable devices, digital eHealth platforms, and remote patient monitoring tools, decision support solutions driven by artificial intelligence are beginning to appear in daily primary care, and this will be an exciting growth area in the near future.
     
    Managing care for patients with chronic diseases remains a major challenge in primary healthcare although massive efforts and resources directed to COVID-19 tended to have overshadowed the pandemics of noncommunicable diseases. Low et al16 adopted a constructivist grounded theory design to examine the decision-making experiences of family carers of older people with dementia towards the use of community care services and residential care services regarding a variety of healthcare and illness decisions, including hospitalisation, seeing family doctor, and deteriorating health issues. A deep understanding of patients’ and their caregivers’ decisions about health seeking, daily living, and lifestyle choices will be of critical importance to strengthen the role of primary care practitioners as the gatekeeper to care.
     
    Community outreach is another essential element of primary healthcare that goes beyond clinical care, and the HKMJ’s ‘Healthcare for Society’ section regularly highlights the exemplary work of local doctors and healthcare workers. For example, Dr Ching-choi Lam has made substantial contributions to vulnerable populations across the age spectrum.17 In particular, the Elderly Services Programme Plan provides strengthened community care support for the elderly people to enhance their confidence in living at home and in considering community care as a desirable alternative to residential aged care. This represents a significant paradigm shift in our understanding of how primary healthcare could contribute to tackling the long-term care needs that often arise from multimorbidity, frailty, disability, and dependence to achieve ‘Ageing in Place’. Another example is Dr Yu-cheung Ho, who is dedicated to providing a variety of health-related campaigns and humanitarian work that target poverty and healthcare together.18 The dedication to improve equity in medical services and health outcomes is in line with the ultimate goals of primary healthcare, and support from local healthcare workforce engaging in charitable contributions could further help orient the service delivery to local healthcare needs and priorities.
     
    Primary healthcare will continue to be of paramount value for meeting the healthcare needs of individuals, families, and communities within a larger society. In Hong Kong, with the establishment of the Primary Healthcare Commission and the launch of the Primary Healthcare Blueprint, we are looking forward to concerted efforts among key stakeholders in primary care to create a healthier tomorrow.19
     
    Author contributions
    All authors contributed to the editorial, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    The authors have declared no conflict of interest.
     
    References
    1. Poon PK, Wong SY. Primary care doctors and the control of COVID-19. Hong Kong Med J 2021;27:86-7. Crossref
    2. Chau CY. COVID-19 vaccination hesitancy and challenges to mass vaccination. Hong Kong Med J 2021;27:377-9. Crossref
    3. World Health Organization. Regional Office for the Western Pacific. Role of primary care in the COVID-19 response. Available from: https://apps.who.int/iris/handle/10665/331921. Accessed 22 Dec 2022.
    4. Liow Y, Loh VW, Goh LH, et al. COVID-19 primary care response and challenges in Singapore: a tale of two curves. Hong Kong Med J 2021;27:70-2. Crossref
    5. Stengel S, Roth C, Breckner A, et al. Resilience of the primary health care system - German primary care practitioners’ perspectives during the early COVID-19 pandemic. BMC Prim Care 2022;23:203. Crossref
    6. Golechha M, Bohra T, Patel M, Khetrapal S. Healthcare worker resilience during the COVID-19 pandemic: a qualitative study of primary care providers in India. World Med Health Policy 2022;14:6-18. Crossref
    7. Shi Y, Song S, Peng L, et al. Utilisation of village clinics in Southwest China: evidence from Yunnan Province. Hong Kong Med J 2022;28:306-14. Crossref
    8. Yang L, Wang H. Who will protect the health of rural residents in China if village doctors run out? Aust J Prim Health 2019;25:99-103. Crossref
    9. Mercer SW, Patterson J, Robson JP, Smith SM, Walton E, Watt G. The inverse care law and the potential of primary care in deprived areas. Lancet 2021;397:775-6. Crossref
    10. Dowling S, Last J, Finnigan H, Cullen W. Continuing education for general practitioners working in rural practice: a review of the literature. Educ Prim Care 2018;29:151-65. Crossref
    11. Campos-Zamora M, Gilbert H, Esparza-Perez RI, et al. Continuing professional development challenges in a rural setting: a mixed-methods study. Perspect Med Educ 2022;11:273-80. Crossref
    12. Wang HH, Mercer SW. Understanding barriers to adherence to optimal treatment of elevated blood pressure and hypertension-insights from primary care. JAMA Netw Open 2021;4:e2138651. Crossref
    13. Wang HH, Li YT, Wong MC. Leveraging the power of health communication: messaging matters not only in clinical practice but also in public health. Hong Kong Med J 2022;28:103-5. Crossref
    14. Wang HH, Li YT, Wong MC. Strengthening attributes of primary care to improve patients’ experiences and population health: from rural village clinics to urban health centres. Hong Kong Med J 2022;28:282-4. Crossref
    15. Matenge S, Sturgiss E, Desborough J, Hall Dykgraaf S, Dut G, Kidd M. Ensuring the continuation of routine primary care during the COVID-19 pandemic: a review of the international literature. Fam Pract 2022;39:747-61.Crossref
    16. Low LP, Lee DT, Lam LW. Decision-making experiences of family carers of older people with moderate dementia towards community and residential care home services: a grounded theory inquiry (abridged secondary publication). Hong Kong Med J 2022;28(Suppl 3):S24-7.
    17. Tsui M, Cheuk N. Community health advocate from paediatrics to elderly healthcare: an interview with Dr Ching-choi Lam. Hong Kong Med J 2021;27:386-8. Crossref
    18. Chan W, Lo A, Wong K. Services make our community a better place to live: an interview with Dr Yu-cheung Ho. Hong Kong Med J 2022;28:415-6. Crossref
    19. Pang FC, Lai SS. Establishment of the Primary Healthcare Commission. Hong Kong Med J 2023;29:Epub 6 Jan 2023. Crossref

    The evolving role of stereotactic body radiotherapy in the management of liver metastasis

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    The evolving role of stereotactic body radiotherapy in the management of liver metastasis
    Vanessa TY Yeung, FHKCR, FHKAM (Radiology)
    Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China
     
    Corresponding author: Dr Vanessa TY Yeung (yty392@ha.org.hk)
     
     Full paper in PDF
     
    The liver is a common metastatic site for colorectal, lung, and breast cancers. In addition to palliative chemotherapy, there have been advances in therapeutic options for liver-directed therapies, which can prolong patient survival and may be curative. Since the 1960s, hepatic metastasectomy has provided a glimmer of hope to patients with cancer.1 A study in the 1990s revealed a 5-year survival rate of 37% in colorectal patients who underwent liver resection for treatment of one to three liver metastases.2 Improvements in surgical technique, patient selection, and systemic treatment have allowed liver resection to achieve 5-year survival rates of >50%, compared with approximately 5% for patients who receive palliative chemotherapy alone.3
     
    Currently, resectability is defined as the ability to perform complete (R0) resection with adequate preservation of the future liver remnant. The presence of unresectable extrahepatic disease remains a contraindication to liver surgery. For patients who are not good surgical candidates, attractive options include non-surgical liver-directed therapies such as stereotactic body radiotherapy (SBRT), selective internal radiation therapy, transarterial chemoembolisation, hepatic arterial infusion therapy, and radiofrequency ablation.4
     
    Over the years, the role of SBRT in the management of liver metastases has considerably evolved; it is now considered safe and effective therapy. Additionally, SBRT provides excellent local control of liver metastases and carries a comparatively low risk of treatment-related toxicity.5
     
    Patient selection for SBRT is important. Desirable patient characteristics include good performance status with limited disease burden and adequate non-irradiated liver reserve (≥700 cc). Moreover, there is a need for caution regarding the irradiation of liver metastases adjacent to the luminal gastrointestinal tract, which could result in bowel perforation.6 For better outcomes, desirable patient characteristics include limited extrahepatic disease, lesion size ≤3 cm, and fewer than three hepatic lesions.4 Stereotactic body radiotherapy generally provides favourable local control of hepatic metastases; most authors report achieving approximately 80% local control at 2 years if higher biologically equivalent doses are delivered.5 6 7 8
     
    Stereotactic body radiotherapy is administered using a linear accelerator, which precisely delivers high-dose ionising radiation in the form of mega-voltage photons; the treatment is administered in one to five fractions within 14 elapsed days. The dose closely conforms to the target, leading to rapid dose fall-off outside of the target. Usually, SBRT doses are prescribed to the 80% isodose line, which covers at least 95% of the planned target volume.8 Nevertheless, irradiation of the liver can result in radiotherapy-induced liver diseases, which may lead to liver failure and even death, particularly in cases of re-irradiation. In terms of radiobiology, the liver obeys the parallel architecture model; thus, the risk of radiotherapy-induced liver disease is generally proportional to the mean dose of radiation delivered to normal liver tissue. This risk can be minimised by ensuring high accuracy in respiratory motion management via four-dimensional computed tomography, in combination with active breathing control, abdominal compression, or respiratory gating. On-boarding imaging must be conducted before SBRT to allow for the immediate correction of patient positioning.9
     
    In this issue of the Hong Kong Medical Journal, Choi et al10 conducted a retrospective study of 31 patients with liver metastases treated by SBRT between January 2012 and December 2017. Actuarial in-field local control rates at 1, 2, and 3 years after SBRT were 93%, 55%, and 42%, respectively. The median survival was 32.9 months; the 1-year, 2-year, and 3-year actuarial survival rates were 89.6%, 57.1%, and 46.2%, respectively. The treatment was well-tolerated. The authors concluded that patients receiving post-SBRT chemotherapy had significantly longer overall survival, highlighting the need for multimodal treatment with effective systemic therapy, rather than monotherapy with either method alone. This real-world evidence supports the evolving role of SBRT in the management of liver metastases in Hong Kong. There is increasing clinical interest in the use of SBRT to manage liver metastases; this new direction is accompanied by many challenges and questions. Future prospective studies may shed light on the most effective SBRT treatment sequence, key factors concerning patient selection, and optimal systemic treatment (in combination with immunotherapy and chemotherapy) for patients with liver metastasis.
     
    Author contributions
    The author was solely responsible for drafting of the manuscript, approved the final version for publication, and takes responsibility for its accuracy and integrity.
     
    Funding/support
    This editorial has received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    Declaration
    The author has disclosed no conflicts of interest.
     
    References
    1. Scheele J, Stang R, Altendorf-Hofmann A, Paul M. Resection of colorectal liver metastases. World J Surg 1995;19:59-71. Crossref
    2. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999;230:309-18. Crossref
    3. House MG, Ito H, Gönen M, et al. Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. J Am Coll Surg 2010;210:744-52. Crossref
    4. Cervantes A, Adam R, Roselló S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2023;34:10-32. Crossref
    5. Chang DT, Swaminath A, Kozak M, et al. Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer 2011;117:4060-9. Crossref
    6. Das IJ, Dawes SL, Dominello MM, et al. Quality and safety considerations in stereotactic radiosurgery and stereotactic body radiation therapy: an ASTRO safety white paper update. Pract Radiat Oncol 2022;12:e253-68. Crossref
    7. Petrelli F, Comito T, Barni S, et al. Stereotactic body radiotherapy for colorectal cancer liver metastases: a systematic review. Radiother Oncol 2018;129:427-34. Crossref
    8. John RG, Ho F, Appalanaido GK, et al. Can radiotherapy finally “go live” in the management of liver metastases? Hepatoma Res 2020;6:56. Crossref
    9. McPartlin A, Swaminath A, Wang R, et al. Long-term outcomes of phase 1 and 2 studies of SBRT for hepatic colorectal metastases. Int J Radiat Oncol Biol Phys 2017;99:388-95. Crossref
    10. Choi CK, Ho CH, Wong MY, et al. Efficacy, toxicities, and prognostic factors of stereotactic body radiotherapy for unresectable liver metastases. Hong Kong Med J 2023;29:105-11. Crossref

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