Strengthening lung cancer screening in Hong Kong: policy, innovation, and collaborative approaches for early detection and improved outcomes

© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Strengthening lung cancer screening in Hong Kong: policy, innovation, and collaborative approaches for early detection and improved outcomes
Herbert HF Loong, MB, BS, FHKAM (Medicine)1,2; Alan DL Sihoe, MB, BChir, FHKAM (Surgery)3; Derek YT Cheung, MPhil, PhD4; YT Cheung, BSc, PhD5; David CL Lam, MD, PhD6; Joseph SK Au, MB, BS, FHKAM (Radiology)7; Molly SC Li, MB, BS, FHKAM (Medicine)1; Ariel JY Lim, BSc8; Judy YT Li, BSc, MPH8; William Thomas Brown, MEng8; Martin CS Wong, MD, MPH9,10
1 Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Editor, Hong Kong Medical Journal
3 CUHK Medical Centre, Hong Kong SAR, China
4 School of Nursing, The University of Hong Kong, Hong Kong SAR, China
5 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
6 Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
7 Hong Kong Adventist Hospital Oncology Centre, Hong Kong SAR, China
8 Asia Pacific Policy Review and Engagement for Lung Cancer
9 The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
10 Editor-in-Chief, Hong Kong Medical Journal
 
Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
 
 Full paper in PDF
 
On 24 September 2024, the Lung Cancer Care Continuum Policy Forum Series convened in Hong Kong, bringing together leading experts from the health system to assess the current state of lung cancer management, enhance collaboration across specialities, and formulate policy recommendations specific to Hong Kong.1 This inaugural event was the first in a series aimed at evaluating existing research and advancing local lung cancer care practices, with a particular emphasis on improving screening initiatives.
 
Despite the diversity of specialisations represented, the experts unanimously emphasised a shared goal of reducing lung cancer mortality and alleviating the overall burden of the disease. They highlighted the importance of collaboration, data sharing, and open dialogue for aligning efforts towards this common objective. Reflecting the group’s collective perspective, insights and contributions from the presentations and discussions have been consolidated into this editorial.
 
Lung cancer burden in Hong Kong
Lung cancer remains one of the most common and fatal cancers in Hong Kong; the 5978 new cases reported in 2021 constituted 15.5% of all cancer diagnoses.2 The age-standardised mortality rates for lung cancer were 29.7 and 14.0 per 100 000 standard population among men and women, respectively.2 Hong Kong’s current strategy mainly targets tobacco use as the primary cause of lung cancer but lacks a comprehensive framework for screening and treatment.
 
Tobacco control progress is evident in Hong Kong, where the smoking rate was substantially lower than the global average of 22.3%.3 Through sustained efforts, Hong Kong has achieved a steady decline in smoking rates, from 12.4% in 2000 to 9.1% in 2023.4 This progress is attributed to the enforcement of comprehensive smoking control measures, including taxation, implementation of pictorial health warnings, expansion of non-smoking areas, and prohibition of alternative smoking products. However, the unique epidemiology of lung cancer in the region, where the majority of cases occur in non-smokers, underscores the need for broader focus beyond smoking cessation.5
 
The experts identified several key challenges, including the absence of centralised guidelines, limited access to screening and precision diagnostics, and gaps in public awareness and healthcare integration. Currently, the Cancer Expert Working Group on Cancer Prevention and Screening of the Centre for Health Protection does not recommend routine screening for lung cancer among asymptomatic individuals with moderate risk.6 An important barrier remains the lack of a comprehensive lung cancer control plan, resulting in late-stage diagnoses and worse patient outcomes. Additionally, care is primarily managed by specialists, with minimal involvement from primary care physicians. The experts called for the establishment of a dedicated control plan focusing on prevention, screening, treatment, and enhanced care coordination to improve accessibility and outcomes.
 
Importance of screening for early detection
Lung cancer screening is recognised as a critical intervention for early detection, particularly in high-risk populations. Authorities in the United Kingdom, Australia, Taiwan, the United States, China, Singapore, Canada, Korea, and Japan have recommended lung cancer screening for individuals aged 50 to 55 years, with cessation at 70 to 74 years.6 However, Hong Kong has yet to establish a government-funded, population-based screening programme targeting high-risk groups. The Chief Executive’s 2024 Policy Address highlighted the need to explore an artificial intelligence (AI)–assisted lung cancer screening programme.7 The experts strongly supported this initiative, citing the success of the colorectal cancer screening programme for high-risk individuals,8 which demonstrated the feasibility of translating clinical evidence into real-world practice through a multidisciplinary approach. This model could serve as a framework for developing an effective lung cancer screening programme in Hong Kong.
 
Economic implications
The economic implications of lung cancer care were also discussed. The experts emphasised the cost-effectiveness of low-dose computed tomography (LDCT) screening for high-risk smokers and non-smokers. Evidence was presented indicating that, over a lifetime, the incremental cost-effectiveness ratios of LDCT screening are well within the affordability range for Hong Kong’s healthcare expenditures, based on prior experiences with willingness-to-pay thresholds.9 10 Consequently, there is robust justification for the initiation of LDCT-based lung cancer screening among all high-risk individuals.11 This approach has the potential to greatly reduce the lung cancer burden and improve population-level outcomes. A report from regions that have adopted lung cancer screening, including Taiwan12—where the lung cancer epidemiology closely resembles that of Hong Kong—demonstrated a substantial shift towards earlier-stage diagnoses. The ability to detect lung cancer at an earlier stage, combined with timely and appropriate management, can lead to reduced mortality and improved treatment outcomes.
 
Artificial intelligence and innovation
Innovative approaches to lung cancer screening were also presented. The ongoing LC-SHIELD study (Lung Cancer Screening in High-risk Non-smokers by Artificial Intelligence Device) utilises AI to screen high-risk non-smokers, a critical subpopulation considering that >50% of lung cancer cases in East Asia occur in non-smokers.13 The application of AI may enhance the sensitivity and specificity of screening, particularly for individuals with unique risk profiles, such as those with a family history of lung cancer or genetic predisposition. The experts noted the limitations of conventional tools (eg, chest X-rays), which lack the sensitivity of LDCT for detecting early-stage lung cancer.14 There was support for the adoption of innovative methods, including liquid biopsy and AI-enhanced LDCT interpretation, which improve early detection rates but reduce costs by minimising false positives and optimising the screening process. Such innovations offer promising opportunities to enhance lung cancer care in Hong Kong, making screening more efficient and accessible.
 
Expansion and integration of screening into routine care
Lung cancer care in Hong Kong is primarily managed by tertiary care specialists, with limited integration across different levels of the healthcare system. The experts highlighted the success of a community-based charity programme designed to increase public awareness of lung cancer screening. This programme provided a single round of LDCT screening of the thorax to 99 asymptomatic adults with a family history of lung cancer and/or a history of smoking. Positive LDCT results were observed in 47 participants (47%), and lung cancer (all adenocarcinomas) was ultimately diagnosed in six participants (6%).12 This detection rate in Hong Kong appears higher than those reported in recent international trials of LDCT for lung cancer screening,15 16 17 indicating a need to revise eligibility criteria for greater emphasis on family history and to leverage local clinical expertise for lesion assessment. The findings from the programme were subsequently published in an international peer-reviewed medical journal and presented at the 2024 World Conference on Lung Cancer.18
 
The published results underscore the potential for adoption of similar programmes and highlight the benefits of incorporating LDCT screening into routine health checks for high-risk individuals. These findings strengthen the case for enhancing access to screening, supporting early detection efforts, and improving lung cancer outcomes in Hong Kong.
 
Management of incidental findings during low-dose computed tomography screening
Although LDCT is a promising tool, its effectiveness depends on collaboration among multidisciplinary healthcare teams.19 The experts noted the challenge posed by incidental pulmonary nodules, which are frequently detected during LDCT screening but are often benign. These findings can increase patient anxiety and place additional strain on healthcare systems due to unnecessary invasive procedures.20 The experts also emphasised adherence to updated guidelines, such as those from the Fleischner Society, for appropriate management of incidental pulmonary nodules.21 Shared decision-making between patients and healthcare providers was considered essential to ensure that individuals understand the risks and benefits of screening.
 
Resolution of psychosocial barriers
The implementation of lung cancer screening presents challenges related to the psychosocial impact, particularly ‘scanxiety’—the anticipatory anxiety associated with screening preparation, procedures, and results.22 23 The experts highlighted the importance of incorporating psychological support into screening programmes to enhance patient participation and adherence, especially among younger individuals who may avoid screening due to fear.
 
Key recommendations for lung cancer screening in Hong Kong
Based on insights shared during the session, the experts formulated five key recommendations to address critical challenges in lung cancer screening and care in Hong Kong. These recommendations reflect collective expertise and propose a holistic approach to advancing early detection, improving healthcare integration, and enhancing accessibility and outcomes for patients.
  1. Develop a comprehensive lung cancer control plan: Establish a detailed, government-funded plan covering the entire patient care continuum to standardise clinical practices throughout the health system.
  2. Implement system-wide screening programmes: Introduce lung cancer screening initiatives targeting high-risk populations, such as smokers and individuals with genetic predisposition, ensuring that these programmes are accessible and tailored to local needs.
  3. Improve healthcare integration: Strengthen collaboration between primary care providers and specialists to streamline the patient care continuum, particularly in the management of follow-up care for individuals with incidental findings.
  4. Address psychosocial barriers: Incorporate psychological support and patient education into lung cancer screening and management programmes to reduce anxiety and improve participation.
  5. Expand screening programmes using AI technology: Promote research and application of AI-enhanced LDCT screening programmes to enhance early detection and cost-effectiveness.
 
The first session of the Lung Cancer Care Continuum Policy Forum Series concluded with an emphasis on adopting a multipronged approach that involves research, policy advocacy, and patient education. During future sessions that more fully explore the patient care continuum for lung cancer care, the aim will be to achieve consensus regarding a unified strategy that aligns local clinical and policy efforts for lung cancer management. The outcomes of these discussions will play a central role in shaping the future of lung cancer care in Hong Kong, ensuring timely detection, equitable access to care, and improved survival outcomes for future generations.
 
Author contributions
All authors contributed to the concept or design, acquisition of data, analysis or interpretation of data, drafting of the manuscript, and critical revision of the manuscript for important intellectual content. All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
ADL Sihoe has acted as a consultant for AstraZeneca, Medela, and Roche, while receiving support from Medtronic and Nestlé. MSC Li has received grants or contracts from AstraZeneca, Gilead, MSD, Takeda, and Johnson & Johnson. He has received honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from entities including AstraZeneca, Novartis, Amgen, Pfizer, Takeda, ACE Oncology, Gilead, Guardant Health, Janssen, Merck, MSD, and BMS. He has also received support for attending meetings and/or travel from AstraZeneca, Pfizer, Daiichi Sankyo, MSD, Roche, Janssen, and Amgen. Additionally, he has served on advisory boards for AstraZeneca, Pfizer, Takeda, Amgen, AnHeart Therapeutics, Yuhan, BlossomHill Therapeutics, and Janssen. MCS Wong is an honorary medical advisor of GenieBiome Ltd. He is an advisory committee member of Pfizer; an external expert of GlaxoSmithKline; a member of the advisory board of AstraZeneca and has been paid consultancy fees for providing advice on research. Other authors declared no conflicts of interest.
 
Funding/support
This editorial was funded by Roche Diagnostics and MSD. The funders had no involvement in the design of the Forum Series, data collection, analysis, interpretation, or manuscript preparation.
 
References
1. Asia Pacific Policy Review and Engagement for Lung Cancer. First edition of the Lung Cancer Care Continuum Policy Forum Series: Early Detection in Hong Kong. Available from: https://aspirelungcancer.com/news/lung-cancer-care-continuum-policy-forum. Accessed 7 Feb 2025.
2. Centre for Health Protection, Department of Health, Hong Kong SAR Government. Lung cancer. 2024 Jan 12. Available from: https://www.chp.gov.hk/en/healthtopics/content/25/49.html. Accessed 11 Oct 2024.
3. World Health Organization. Tobacco. 2023 Jul 31. Available from: https://www.who.int/news-room/fact-sheets/detail/tobacco. Accessed 14 Oct 2024.
4. Census and Statistics Department, Hong Kong SAR Government. Thematic Household Survey Report–Report No. 79–Pattern of Smoking. 2nd Issue 2024. Available from: https://www.censtatd.gov.hk/en/wbr.html?ecode=B11302012024XX01&scode=380. Accessed 14 Oct 2024.
5. Noronha V, Budukh A, Chaturvedi P, et al. Uniqueness of lung cancer in Southeast Asia. Lancet Reg Health Southeast Asia 2024;27:100430. Crossref
6. Non-communicable Disease Branch, Centre for Health Protection, Department of Health, Hong Kong SAR Government. Lung cancer prevention and screening. June 2023. Available from: https://www.chp.gov.hk/files/pdf/6_lung_cancer_prevention_and_screening_eng.pdf. Accessed 11 Feb 2025.
7. Hong Kong SAR Government. The Chief Executive’s 2024 Policy Address. Oct 2024. Available from: https://www.policyaddress.gov.hk/2024/en/. Accessed 1 Nov 2024.
8. Department of Health, Hong Kong SAR Government. Colorectal Cancer Screening Programme. Available from: https://www.colonscreen.gov.hk/en/public/index.html. Accessed 11 Feb 2025.
9. Loong H, Pan X, Chiu CH, et al. P1.17-03 Cost-effectiveness of low-dose computerized tomography lung cancer screening in high-risk non-smokers and smokers in Hong Kong. J Thorac Oncol 2023;18 Suppl:S223. Crossref
10. Census and Statistics Department, Hong Kong SAR Government. Table 310-31001: Gross Domestic Product (GDP), implicit price deflator of GDP and per capita GDP. 2024 Nov 15. Available from: https://www.censtatd.gov.hk/en/web_table.html?id=310-31001. Accessed 12 Feb 2025.
11. Loong HH, Pan X, Chiu CH, et al. 486P–Fiscal feasibility and implications of integrating lung cancer screening into Hong Kong’s healthcare system [poster]. 2023 Dec 2. Available from: https://oncologypro.esmo.org/meeting-resources/esmo-asia-congress-2023/fiscal-feasibility-and-implications-of-integrating-lung-cancer-screening-into-hong-kong-s-healthcare-system. Accessed 1 Nov 2024.
12. Yang PC, Chen TH, Huang KP, Lin LJ, Wu CC. Taiwan national lung cancer early detection program for heavy smokers and non-smokers with family history of lung cancer [abstract]. J Clin Oncol 2024;42;16_suppl:8009. Crossref
13. Zhou F, Zhou C. Lung cancer in never smokers—the East Asian experience. Transl Lung Cancer Res 2018;7:450-63. Crossref
14. Amicizia D, Piazza MF, Marchini F, et al. Systematic review of lung cancer screening: advancements and strategies for implementation. Healthcare (Basel) 2023;11:2085. Crossref
15. National Lung Screening Trial Research Team; Aberle DR, Adams AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395-409. Crossref
16. Yang P. PS01.02 National lung cancer screening program in Taiwan: the TALENT Study. J Thorac Oncol 2021;16:S58. Crossref
17. de Koning HJ, van der Aalst CM, de Jong PA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med 2020;382:503-13. Crossref
18. Sihoe AD, Fong NK, Yam AS, Cheng MM, Yau DL, Ng AW. Real-world first round results from a charity lung cancer screening program in East Asia. J Thorac Dis 2024;16:5890-8. Crossref
19. Ramaswamy A. Lung cancer screening: review and 2021 update. Curr Pulmonol Rep 2022;11:15-28. Crossref
20. Lin Y, Khurelsukh K, Li IG, et al. Incidental findings in lung cancer screening. Cancers 2024;16:2600. Crossref
21. Lam DC, Liam CK, Andarini S, et al. Lung cancer screening in Asia: an expert consensus report. J Thorac Oncol 2023;18:1303-22. Crossref
22. Feiler B. Scanxiety. Fear of a postcancer ritual. Time 2011;177:56.
23. Goodwin B, Anderson L, Collins K, et al. Anticipatory anxiety and participation in cancer screening. A systematic review. Psychooncology 2023;32:1773-86. Crossref

Screening for upper gastrointestinal cancer in Hong Kong

© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Screening for upper gastrointestinal cancer in Hong Kong
Chloe WK Hui1; Justin NF Lam1; KH Man1; Claire Chenwen Zhong, MPhil, PhD2,3; Junjie Huang, MSc, PhD2,3,4; Martin CS Wong, MD, MPH2,3,5; Hon Chi Yip, MB, ChB, FHKAM (Surgery)1
1 Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
2 The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
3 Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
4 Editor, Hong Kong Medical Journal
5 Editor-in-Chief, Hong Kong Medical Journal
 
Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk); Dr Hon Chi Yip (hcyip@surgery.cuhk.edu.hk)
 
 Full paper in PDF
 
Introduction
Gastric and oesophageal cancers are both highly lethal but often overlooked diseases in Hong Kong. During the early stages of these cancers, patients are typically asymptomatic or exhibit only mild symptoms, leading to late diagnoses, delayed treatment, and poor prognoses. Although the prevalences of both cancers have declined in recent decades, coinciding with a reduction in the number of smokers,1 the likelihood of advanced metastasis at diagnosis and the associated mortality rates remain substantially higher relative to cancers such as prostate cancer.2 In 2021, 1306 cases of gastric cancer were newly diagnosed1; 631 patients succumbed to the disease in the same year, making it the sixth leading cause of cancer-related deaths in Hong Kong.1 From 2017 to 2021, the mortality-to-incidence ratios were 0.48 for men and 0.44 for women, reflecting a low 5-year survival rate.3 Although the prevalence of oesophageal cancer has declined in recent years, its mortality rate remains high.4 In 2021, 397 new cases of oesophageal cancer were diagnosed, and 299 deaths were reported in the same year.5 By 2021, it was the tenth leading cause of cancer-related deaths in Hong Kong.6
 
Oesophagogastroduodenoscopy indications in Hong Kong
Among all gastrointestinal (GI) cancers, population screening in Hong Kong is only available for colorectal cancer (via the faecal immunochemical test). Due to the comparatively lower incidences of upper GI cancers, no formal screening programme currently exists. Diagnosis of these cancers mainly relies on opportunistic endoscopic screening in patients who present with non-localising symptoms. Non-invasive screening tools for upper GI cancers are currently lacking, despite some promising modalities under investigation. A recent study validated a scoring system that incorporates weighted risk factors based on their contribution to gastric cancer development.7 However, in Hong Kong’s public hospitals, oesophagogastroduodenoscopy (OGD) is primarily indicated for suspected or confirmed cases of peptic ulcer disease, GI bleeding, oesophageal or gastric cancer; it is also indicated for symptoms such as indigestion, acid reflux, or dysphagia.8 By the time diagnostic symptoms appear, most patients display advanced cancer beyond curative treatment, resulting in poor survival outcomes. Thus, a comprehensive screening model for upper GI cancers is urgently needed.
 
Global screening strategies
Screening approaches for gastric and oesophageal cancers considerably vary worldwide, shaped by regional factors such as cancer prevalence, healthcare infrastructure, and medical policies. The local incidences of these cancers serve as the main determinants of screening strategies.
 
In regions with higher incidence rates, broader population-based screening is often utilised. In Japan, population-based screening is conducted using endoscopic and radiographic examinations, as outlined in the Japanese Guidelines for Gastric Cancer Screening.9 Endoscopic screening was added in 2014, despite challenges related to accessibility.9 Similarly, in Korea, biennial screening for gastric cancer is conducted among individuals aged >40 years10 via barium swallow, computed tomography, or endoscopy.11 In China where gastric cancer is also prevalent, screening strategies focus on highrisk populations through endoscopic examinations and serum pepsinogen testing12; high-risk groups are identified based on geographical prevalence.12 Regarding oesophageal cancer, similar targeted approaches are implemented. In regions with high rates of oesophageal squamous cell carcinoma, such as the Taihang Mountain range in China, population-based screening includes endoscopic examinations and cytology testing.13
 
Hong Kong, exhibiting comparatively lower incidences of both gastric and oesophageal cancers, highlights the limitations of a one-size-fits-all approach to cancer screening. A microsimulation model projecting population-wide gastric cancer screening in low-prevalence regions, such as the US, indicated a cost per quality-adjusted life year exceeding US$100 000, suggesting that such an approach is economically inefficient.14 Therefore, opportunistic screening focused on high-risk individuals is considered a more cost-effective strategy in these settings.
 
Countries where the incidence of gastric cancer is lower (eg, the US, the UK, and Singapore) do not implement routine population-wide screening programmes. Screening in these regions is more selective, targeting high-risk individuals, such as those with a family history of gastric cancer or carriers of Helicobacter pylori. In the US, targeted oesophageal cancer screening is recommended for individuals with Barrett’s oesophagus, given their increased risk of oesophageal adenocarcinoma.15 The frequency of endoscopic surveillance is determined by the severity of dysplasia identified in Barrett’s oesophagus.15 Medium-incidence countries have demonstrated potential benefits from targeting specific high-risk populations, often based on age.16
 
This variability in screening protocols underscores the need for region-specific strategies that consider local disease prevalence, healthcare infrastructure, and socio-economic factors.
 
Currently available prediction models
Rather than assessing the risk of each cancer individually, a combined gastroesophageal risk prediction model offers a comprehensive assessment of the overall risk for developing upper GI cancers. This approach directly informs the need for OGD, providing clinicians with an objective framework to identify and prioritise patients who would benefit most from endoscopic evaluation. Only one combined gastroesophageal cancer risk prediction model has been developed for the general population.17 Although this model demonstrates relatively high discriminatory capability, as validated by two separate large-cohort studies,17 18 it may not be directly applicable to clinical practice in Hong Kong for the following reasons.
 
First, the model was developed and validated in the UK, primarily using data from a Western population.17 18 Variations in cancer risk factors among ethnic groups are well documented; for example, the incidence of gastric cancer is higher in Asian populations due to gene-environment interactions.19 Therefore, the hazard ratios for risk factors derived from the UK population may not be suitable for the Southern Chinese population in Hong Kong. A model tailored to risk factors directly relevant to the Hong Kong population would likely provide greater discriminatory capability and clinical utility.
 
Second, the existing model heavily relies on the presence of ‘alarm symptoms’ for gastroesophageal cancer reported by patients to their general practitioners, such as dysphagia, abdominal pain, and appetite loss. Although these symptoms are sensitive indicators of cancer, their use as primary predictors limits the model’s effectiveness in identifying patients at elevated risk during the early stages of cancer progression. Early-stage cancers are often asymptomatic or associated with subtle symptoms that may not be clinically apparent. The incorporation of readily available and objectively measurable factors, such as demographic data and medical history, into the model could facilitate more effective stratification of patients requiring OGD screening, enabling earlier medical intervention before substantial disease progression.
 
Conclusion
The high mortality-to-incidence ratios associated with gastric and oesophageal cancers represent considerable public health challenges in Hong Kong. However, the current methods for cancer risk stratification and patient selection for further investigation remain inadequate. The use of de-identified clinical data from patients previously diagnosed with oesophageal and gastric cancers, accessible through the Clinical Data Analysis and Reporting System of the Hospital Authority, would enable the development of a prediction model tailored to the Hong Kong population. The incorporation of such a prediction model into routine clinical practice could enhance the early detection of upper GI cancers, facilitate timely medical intervention, and improve treatment outcomes. This approach offers a promising strategy for reducing the mortality associated with upper GI cancers in Hong Kong.
 
Author contributions
Concept or design: All authors.
Acquisition of data: CWK Hui, JNF Lam, KH Man.
Analysis or interpretation of data: CWK Hui, JNF Lam, KH Man.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
 
All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
All authors have disclosed no conflicts of interest.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
References
1. Centre for Health Protection, Department of Health, Hong Kong SAR Government. Stomach cancer. 2024 Jan 12. Available from: https://www.chp.gov.hk/en/healthtopics/content/25/55.html. Accessed 11 Nov 2024.
2. Cancer Online Resource Hub, Hong Kong SAR Government. Prostate cancer. Available from: https://www.cancer.gov.hk/en/hong_kong_cancer/common_cancers_in_hong_kong/prostate_cancer.html. Accessed 7 Nov 2024.
3. Hospital Authority. Stomach cancer in 2021. 2023. Available from: https://www3.ha.org.hk/cancereg/pdf/factsheet/2021/stomach_2021.pdf. Accessed 10 Nov 2024.
4. Wang L, Du J, Sun H. Evolution of esophageal cancer incidence patterns in Hong Kong, 1992-2021: an age-period- cohort and decomposition analysis. Int J Public Health 2024;69:1607315. Crossref
5. Centre for Health Protection, Department of Health, Hong Kong SAR Government. Oesophageal cancer. 2024 Jan 12. Available from: https://www.chp.gov.hk/en/healthtopics/content/25/50.html. Accessed 20 Nov 2024.
6. Hong Kong Anti-Cancer Society. Latest cancer statistics. Available from: https://www.hkacs.org.hk/en/medicalnews.php?id=213. Accessed 7 Nov 2024.
7. Wong MC, Leung EY, Yau ST, et al. Prediction algorithm for gastric cancer in a general population: a validation study. Cancer Med 2023;12:20544-53. Crossref
8. Coordinating Committee in Internal Medicine, Hospital Authority. Patient information on oesophagogastroduodenoscopy (OGD). 2023 Nov 30. Available from: https://www.ekg.org.hk/pilic/public/IM_PILIC/IM_OGD_0049_eng.pdf. Accessed 9 Nov 2024.
9. Yashima K, Shabana M, Kurumi H, Kawaguchi K, Isomoto H. Gastric cancer screening in Japan: a narrative review. J Clin Med 2022;11:4337. Crossref
10. Ryu JE, Choi E, Lee K, et al. Trends in the performance of the Korean National Cancer Screening Program for Gastric Cancer from 2007 to 2016. Cancer Res Treat 2022;54:842-9. Crossref
11. Kim TH, Kim IH, Kang SJ, et al. Korean Practice Guidelines for Gastric Cancer 2022: an evidence-based, multidisciplinary approach. J Gastric Cancer 2023;23:3-106. Crossref
12. Fan X, Qin X, Zhang Y, et al. Screening for gastric cancer in China: advances, challenges and visions. Chin J Cancer Res 2021;33:168-80. Crossref
13. Zheng Y, Niu X, Wei Q, Li Y, Li L, Zhao J. Familial esophageal cancer in Taihang Mountain, China: an era of personalized medicine based on family and population perspective. Cell Transplant 2022;31:9636897221129174. Crossref
14. Lee YT. Gastric cancer screening. J Soc Physicians Hong Kong 2023;15:13-5.
15. Fitzgerald RC, di Pietro M, Ragunath K, et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett’s oesophagus. Gut 2014;63:7-42. Crossref
16. Dan YY, So JB, Yeoh KG. Endoscopic screening for gastric cancer. Clin Gastroenterol Hepatol 2006;4:709-16. Crossref
17. Hippisley-Cox J, Coupland C. Identifying patients with suspected gastro-oesophageal cancer in primary care: derivation and validation of an algorithm. Br J Gen Pract 2011;61:e707-14. Crossref
18. Collins GS, Altman DG. Identifying patients with undetected gastro-oesophageal cancer in primary care: external validation of QCancer® (Gastro-Oesophageal). Eur J Cancer 2013;49:1040-8. Crossref
19. Ashktorab H, Kupfer SS, Brim H, Carethers JM. Racial disparity in gastrointestinal cancer risk. Gastroenterol 2017;153:910-23. Crossref

Clinical errors and mistakes: civil or criminal liability?

Hong Kong Med J 2025 Feb;31(1):9–11 | Epub 7 Feb 2025
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Clinical errors and mistakes: civil or criminal liability?
Albert Lee, MD, LLM1,2,3,4; Monique A Anawis, MD5; JD, Roy G Beran, MD, FRACP6,7,8; Tracy Cheung, LLB, PCLL9,10; Calvin Ho, LLM, JSD2,11; Hwan Kim, LLM, CPCU12
1 Emeritus Professor, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Centre for Medical Ethics and Law, Faculties of Law and Medicine, The University of Hong Kong, Hong Kong SAR, China
3 Adjunct Professor, International Centre for Future Health System, University of New South Wales, Sydney, Australia
4 Vice President (Asia), World Association for Medical Law, United States
5 Clinical Assistant Professor of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, United States
6 Conjoint Professor, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia
7 Conjoint Professor, Western Sydney University, Sydney, Australia
8 Professor, Griffith University, Gold Coast, Australia
9 Consultant, Wanda Tong & Co, Hong Kong SAR, China
10 Lecturer, School of Law, City University of Hong Kong, Hong Kong SAR, China
11 Associate Professor, Faculty of Law, Monash University, Melbourne, Australia
12 Senior Vice President, Healthcare Division (Asia Pacific), Allied World Assurance Company
 
Corresponding author: Dr Albert Lee (alee@cuhk.edu.hk); Ms Tracy Cheung (tracycheung@bosc.com.hk)
 
 Full paper in PDF
 
 
Civil liability of doctors arises when there is a clinically negligent act or omission resulting in harm as a consequence of a doctor not meeting the standard of care as expected from reasonable medical practice or failure to warn.1 Do clinical errors and mistakes necessarily equate to negligence? The essential elements required to establish negligence, are: (1) the existence of a duty of care owed to the patient; (2) a breach of duty as determined by standard of care; (3) the patient has experienced harm; and (4) a causal connection, between the defendant’s careless act and the resulting damage incurred with the damage considered foreseeable and not too remote.2 In Hatcher v Black,3 Lord Denning explained a case that a woman P, who suffered side-effects from an operation on her throat and sued the surgeon concerned. Denning J stated that:
“…on the road or in a factory there ought not to be any accidents if everyone used proper care, but in a hospital there was always a risk. It would be disastrous to the community if a doctor examining a patient or operating at the table, instead of getting on with his work, were forever looking over his shoulder to see if someone was coming up with a dagger. The jury should not find the defendant negligent simply because one of the risks inherent in an operation actually took place, or because in a matter of opinion he made an error of judgement. They should find him liable only if he had fallen short of the standard of medical care, so that he was deserving of censure…”
(The jury found in favour of the defendant).
 
According to the Bolam test,4a doctor will not be found negligent if he/she has acted in accordance with a practice accepted as proper by a reasonable body of medical opinion”. It appears unreasonable or of limited social value to impose a criminal sanction on a medical practitioner for genuine clinical errors and mistakes.
 
The majority of litigation, following alleged medical malpractice, is brought under the tort of negligence (civil claims) and the remedy sought is monetary compensation. Criminalisation of medical malpractice falls into the realm of retributive justice which is a system of criminal justice focusing solely on punishment, rather than deterrence or the rehabilitation of offenders. The punishment should be in proportion to the seriousness of the crime committed.5 The negligent act should be culpable to constitute a criminal act, such as gross negligence manslaughter (GNM).6 This raises pertinent issues and questions in health care, such as: Is criminal prosecution really promoting patient safety and safeguarding public interest? Should the focus be on conduct rather than outcome? Should the use of restorative justice, emphasising retribution, surpass deterrence and rehabilitation?7
 
An expert panel conducted a pre-recorded seminar, followed by an interactive panel, to analyse GNM, in the healthcare setting, across different common law jurisdictions (including Australia, England, Hong Kong, Singapore and the United States) in November 2021.8 A paper is under preparation which reports the critical points of those presentations, together with further analyses of cases and literature in jurisdictions adopting common law, to provide a better understanding of how clinical negligence might lead to criminal proceedings. This editorial aims to recap the English case of Bawa-Garba,9 to discuss the factors to be taken into consideration for medical crime. There were a number of high-profile criminal investigations and prosecutions of healthcare professionals (HCPs) in England, with no offence recorded in Scotland and only 14 HCPs being charged with offences of criminal negligence in Canada and just over 30 GNM prosecutions since 1830 in England.7
 
In the Garba case,9 the jury found the defendant paediatrician’s conduct to be “truly exceptionally bad” (meaning it was far below the standard of care expected by a competent paediatrician and that it amounted to the criminal offence of GNM). The literature has raised criticisms of the findings for failing to give due consideration to organisational factors, such as system failure or lack of permanent supporting staff.6 10 The Box summarises the negligence of the defendant doctor and factors contributing to her negligence.
 

Box. R v Hadiza Bawa-Garba9
 
The investigations and prosecutions regarding Garba were perceived as arbitrary and inconsistent.11 This resulted in a rapid policy review, as described in Gross Negligence Manslaughter in Healthcare in 2018.12 The panel was clear that HCPs could not be, or be seen to be, above the law and should be held to account where necessary. It was equally evident that HCPs are working in the complexity of a modern healthcare system, under a stressful environment and this should also be taken into consideration when deciding whether to pursue a GNM investigation. Doctors who have made an erroneous or suboptimal decision, without the intent to harm, acted in a manner that arguably does not rise to the level of criminal blameworthiness.13
 
A negligent doctor should not be held criminally liable for a brief lapse of concentration or an inadvertent error of judgement and it has been argued that three factors: (1) awareness; (2) choice (choose to run the risk); and (3) control (has the opportunity to act differently) should be present for the establishment of the negligent conduct to be considered culpable within the criminal context.13 An error is trying to do the right thing but performing same wrongly which does not reflect an intentional deviation from accepted practices.14
 
Would Garba9 be ruled differently, with consideration of culpability and violation of the three factors of awareness, choice and control? Dr Bawa-Garba’s fitness to practise had been found to be impaired causing her suspension from practising for 1 year by the tribunal. The General Medical Council appealed, on the ground that the tribunal should have ordered her to be erased from the register and substituted the sanction of erasure for that of suspension.15 The ruling led to a backlash from doctors who believed that she should not have been singled out for punishment because of the multiple system failures which led to the boy’s death. Dr Bawa-Garba finally won an appeal against being struck off, restoring the 1-year suspension.16 The judgement states that the task of the tribunal was to decide what sanction would “most appropriately meet the overriding objective of protecting the public.”16 Taking into account the particular circumstances of this case and the aggravating and mitigating factors, the Court of Appeal felt that erasure was not necessary to meet the objectives of: protecting the public; maintaining public confidence; and promoting and upholding proper professional standards. The Court considered that the expert tribunal was entitled to form the view that a suspension order could meet these statutory objectives.
 
Dr Bawa-Garba is now back at work and has finished her specialist training.17 The main lessons learned are: to analyse all circumstances; to assess whether the negligent act is truly exceptionally bad; and whether there were extenuating circumstances that need to be taken into account.
 
Author contributions
Concept or design: All authors.
Acquisition of data: All authors.
Analysis or interpretation of data: All authors.
Drafting of the manuscript: A Lee, T Cheung.
Critical revision of the manuscript for important intellectual content: All authors.
 
All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
 
Conflicts of interest
All authors have disclosed no conflicts of interest.
 
Declaration
This editorial has been presented in the Gross Negligence Manslaughter Seminar and Panel Discussion: Reflection from different Jurisdictions adopting Common Law organised by the Centre for Health Education and Health Promotion of The Chinese University of Hong Kong and co-organised by the Centre for Medical Ethics and Law of The University of Hong Kong, New Medico-Legal Society of Hong Kong, American College of Legal Medicine, the Australasian College of Legal Medicine, and the Healthcare Division of Allied World Assurance Company held in November 2021.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
Disclaimer
The opinions expressed reflect the views of the authors not the institutions to which they are affiliated.
 
References
1. Lee A. Clinical liability in Hong Kong: revisiting duty and standard of care. In: Raposo VL, Beran RG, editors. Medical Liability in Asia and Australasia. Ius Gentium: Comparative Perspectives on Law and Justice, vol 94. Singapore: Springer; 2022. Crossref
2. Jones M, Dugdale AM, Simpson M. Clerk & Lindsell on Torts. 23rd Edition, London: Sweet & Maxwell; 2020.
3. Bolam v Friern Hospital Management Committee. 1 WLR 582; 1957.
4. Hatcher v Black. The Times. 2 July 1954.
5. Meyer JF. Retributive Justice. Encyclopedia Britannica, 12 Sep 2014. Available from: https://www.britannica.com/topic/retributive-justice. Accessed 6 Jan 2024.
6. Lee A. Key elements of gross negligence manslaughter in the clinical setting. Hong Kong Med J 2023;29:99-101. Crossref
7. Farrell AM, Alghrani A, Kazarian M. Gross negligence manslaughter in healthcare: time for a restorative justice approach? Med Law Rev 2020;28:526-48. Crossref
8. Anawis M, Beran RG, Cheung T, Ho C, Kim H, Lee A. Gross Negligence Manslaughter Seminar and Panel Discussion: Reflection from different Jurisdictions adopting Common Law. November 2021. Available from: https://www.chep.cuhk.edu.hk/GNM/. Accessed 15 Jan 2024.
9. R v Hadiza Bawa-Garba. EWCA Crim 1841; 2016.
10. Cohen D. Back to blame: the Bawa-Garba case and the patient safety agenda. BMJ 2017;359:j5534. Crossref
11. Lee DW, Tong KW. What constitutes negligence and gross negligence manslaughter? In Chiu JS, Lee A, Tong KW, editors. Healthcare Law and Ethics: Principles and Practices. Hong Kong: City University of Hong Kong Press; 2023.
12. Department of Health and Social Care of the United Kingdom. Gross Negligence Manslaughter in Healthcare. The Report of a Rapid Policy Review. June 2018. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/717946/Williams_Report.pdf. Accessed 25 Jan 2025.
13. Robson M, Maskill J, Brookbanks W. Doctors are aggrieved—should they be? Gross negligence manslaughter and the culpable doctor. J Crim Law 2020;84:312-40. Crossref
14. Merry A, Brookbanks W. Violations. In: Merry and McCall Smith’s Errors, Medicine and the Law. 2nd Edition. Cambridge: Cambridge University Press; 2017: 141-82. Crossref
15. GMC v Dr Bawa-Garba. EWHC 76 (Admin); 2018.
16. Hadiza Bawa-Garba v GMC. EWCA Civ 18979; 2018.
17. Dyer C. Hadiza Bawa-Garba can return to practice under close supervision. BMJ 2019;365:l1702. Crossref

Disabilities and professional training: a tripartite consensus statement by the Hong Kong Academy of Medicine and the two medical schools in Hong Kong

Hong Kong Med J 2025 Feb;31(1):4–5 | Epub 20 Dec 2024
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Disabilities and professional training: a tripartite consensus statement by the Hong Kong Academy of Medicine and the two medical schools in Hong Kong
Gilberto KK Leung
Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
 
Corresponding author: Prof Gilberto KK Leung (gilberto@hku.hk)
 
 Full paper in PDF
 
 
In a fair and equitable society, individuals with disabilities should have access to the same educational opportunities as those who are not so affected. In Hong Kong, the principle of equal opportunities in education is given legal effect requiring training institutions to provide ‘reasonable accommodations’ to address the educational needs of disabled individuals.1
 
Tension may arise, however, when a disabled medical student or trainee doctor undertakes educational activities or assessments that exceed their physical and/or mental capabilities due to their disability, unless substantial accommodations are implemented. The prioritisation of patient welfare in medical ethics, placing it ‘above and beyond considerations of personal interests and private gains’ may give rise to a perceived conflict between the ideal of equal opportunities and the responsibility of training institution to ensure that professional standards and patient safety are not compromised.2
 
Should a medical student with impaired hearing be permitted to use hearing aids during lectures? Should a trainee with colour vision deficiency be provided specially annotated histological micrographs during examinations? What about a student with an anxiety disorder who requests extra time for a clinical competency test?
 
Uncommon in the past, these questions have been raised with increasing frequency in recent years. The traditional view that professional training requirements should be undaunted and taking precedence over all other considerations no longer holds, as it is now widely recognised that a diverse healthcare workforce, inclusive of disabled individuals, contributes to better overall patient care.3 Even long-standing and expressly stipulated regulations could be challenged if not justifiable on the grounds of non-discrimination. In the United Kingdom August this year, legal action was successfully brought against the Royal College of General Practitioners for failing to provide a disabled trainee with ‘reasonable adjustments,’ including additional time for examinations.4 A more nuanced and balanced approach is clearly needed.
 
In response, the Hong Kong Academy of Medicine and the medical faculties of The University of Hong Kong and The Chinese University of Hong Kong recently issued a consensus statement on supporting students and trainees with disabilities.5 This joint statement is the product of discussions held under the auspices of a quadripartite platform established in 2023, under a memorandum of understanding involving the aforementioned three institutions and the Hospital Authority.6 (The latter is not a party to the joint statement because it primarily functions as an employer, rather than an educational institution.)
 
The result is a principles-based, high-level policy instrument setting out the parties’ commitment to equal opportunities and their legal obligations to provide disabled individuals in training with ‘reasonable accommodations.’ To uphold professional standards of practice and comply with relevant legal provisions, such accommodations should not impose an ‘unjustifiable hardship’ on the institution, such as when the accommodation compromises the standard or level of professional education and training.1 An emphasis is placed on procedural fairness, transparency, and accountability; every request for special accommodation must be assessed on a case-by-case basis, considering the unique circumstances presented. ‘Blanket policies’ regarding accommodation are discouraged, and an appeal mechanism must be in place. The two medical schools and the 15 constituent colleges of the Hong Kong Academy of Medicine are required to establish their own internal procedures for assessing requests, given the wide range of learning objectives, curriculum designs, and assessment methodologies involved. A common template serves as a reference to promote intra- and inter-institutional consistency.
 
The real-world implementation of this policy will depend largely on the nature and scope of the ‘reasonable accommodations’ identified in each case, subject to the broad legal definition of ‘disability’ which educational establishments must carefully consider. The Code of Practice on Education issued by the Equal Opportunities Commission provides helpful guidance on this matter, including guidance for determining what constitutes ‘unjustifiable hardship’, which, if present, may exempt educational establishments from liability for not providing an accommodation.1 The overarching principle is that requests for special accommodations must be considered, but training institutions are obligated only to provide accommodations which are reasonable and do not constitute ‘unjustifiable hardship’ for the institution, as determined on a case-by-case basis.
 
Going forward, several outstanding issues require examination by the quadripartite platform. First, disabled individuals often face barriers when applying for admission to training programmes. Institutions must ensure that their admission procedures do not discriminate against such individuals. Second, rather than relying on a reactive approach to addressing requests for accommodation, proactive mechanisms could be developed to identify and support disabled individuals at an early stage. Third, it remains unclear whether and under what circumstances a disabled individual who fails to meet the required professional standards due to disabilities, despite the best available accommodations, should be referred to the ‘fitness to practise’ procedures of the two medical schools or the Health Committee of the Medical Council of Hong Kong for further assessment. Finally, it is common knowledge that a disabled individual may achieve and maintain clinical competency in specific areas of practice, regardless of incompetency in others.3 Whether qualifying examinations should continue to be based on the premise that all medical students must achieve the same catalogue of clinical competencies, regardless of their intended career paths, and whether a regulatory mechanism should be introduced for granting conditional registrations limited to a specified and restricted scope of practice are questions deserving of our attention.
 
Author contributions
The author contributed to the editorial, approved the final version for publication, and takes responsibility for its accuracy and integrity.
 
Conflicts of interest
The author has disclosed no conflicts of interest.
 
Funding/support
This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
 
References
1. Equal Opportunities Commission. Disability Discrimination Ordinance, Code of Practice on Education. Available from: https://www.eoc.org.hk/eoc/Upload/cop/ddo/cop_edu_e.htm. Accessed 19 Nov 2024.
2. The Medical Council of Hong Kong. Hong Kong Doctors (2017). Available from: https://www.mchk.org.hk/english/publications/files/HKDoctors.pdf. Accessed 19 Nov 2024.
3. Snashall D. Doctors with disabilities: licensed to practice? Clin Med (Lond) 2009;9:315-9. Crossref
4. Limb M. RCGP’s exam policy was unlawful, says landmark ruling in favour of doctors with disabilities. BMJ 2024;386:q1892. Crossref
5. Consensus Statement issued by the Hong Kong Academy of Medicine (“HKAM”), the Faculty of Medicine of The Chinese University of Hong Kong (“CUMed”) and the LKS Faculty of Medicine of The University of Hong Kong (“HKUMed”) with respect to the education and training of medical students and specialist trainees requiring special accommodation due to disability or special educational needs (“SENs”). Available from: https://www.hkam.org.hk/sites/default/files/2024-12/2024 Consensus Statement re SEN with HKU and CUHK.pdf. Accessed 18 Dec 2024.
6. Hong Kong Academy of Medicine, CU Medicine, HKUMed, and Hospital Authority forge quadripartite collaboration on healthcare education with memorandum of Understanding. Press release. Available from: https:// www.hkam.org.hk/sites/default/files/PDFs/2023/Press%20Release%20-%20HKAM%20Quadripartite%20MEC%20-%20MOU%20Signing%2020231127%20(clean)_ENG.pdf?v=1729296000078. Accessed 17 Nov 2024.

Faculty development for postgraduate medical education in Hong Kong

© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
EDITORIAL
Faculty development for postgraduate medical education in Hong Kong
HY So, FHKAM (Anaesthesiology)1; Philip KT Li, FHKAM (Medicine)2; Benny CP Cheng, FHKAM (Anaesthesiology)3; Faculty Development Workgroup, Hong Kong Jockey Club Innovative Learning Centre for Medicine#; Gilberto KK Leung, FHKAM (Surgery)4
1 Educationist, Hong Kong Academy of Medicine, Hong Kong SAR, China
2 Vice-President (Education and Examinations), Hong Kong Academy of Medicine, Hong Kong SAR, China
3 Honorary Director, Hong Kong Jockey Club Innovative Learning Centre for Medicine, Hong Kong SAR, China
4 President, Hong Kong Academy of Medicine, Hong Kong SAR, China
# Members of Faculty Development Workgroup:
Albert KM Chan (The Hong Kong College of Anaesthesiologists),
Dominic KL Ho (The College of Dental Surgeons of Hong Kong),
Franklin TT She (The College of Dental Surgeons of Hong Kong),
YF Choi (Hong Kong College of Emergency Medicine),
Peter Anthony Fok (The Hong Kong College of Family Physicians),
KK Tang (The Hong Kong College of Obstetricians and Gynaecologists),
Jason CS Yam (The College of Ophthalmologists of Hong Kong),
PT Chan (The Hong Kong College of Orthopaedic Surgeons),
KC Wong (The Hong Kong College of Otorhinolaryngologists),
SP Wu (Hong Kong College of Paediatricians),
Rock YY Leung (The Hong Kong College of Pathologists),
YM Kan (Hong Kong College of Physicians),
CW Law (The Hong Kong College of Psychiatrists),
Kevin KF Fung (Hong Kong College of Radiologists),
Skyi YC Pang (The College of Surgeons of Hong Kong)
 
Corresponding author: Dr HY So (sohingyu59@gmail.com)
 
 Full paper in PDF
 
Competency-based medical education and faculty development
By the late 20th century, traditional teaching methods in postgraduate medical education were considered inadequate for preparing doctors to navigate modern healthcare systems, thereby posing risks to patient safety. This realisation led to a global shift towards competency-based medical education.1 2 3 The Hong Kong Academy of Medicine (HKAM) identifies seven key competencies essential for contemporary medical practitioners, namely, professional expertise, interpersonal communication, teamwork, leadership, professionalism, academia, and health promotion. The achievement of proficiency in these areas requires novel approaches to teaching and learning.
 
Traditional postgraduate medical education is often centred around two main principles: the transmission of knowledge and the ‘see one, do one, teach one’ model. Although knowledge acquisition is essential, mere memorisation of facts and information does not lead to excellence in medical practice. Effective education requires more than the delivery of information. It involves selecting content aligned with learning objectives, organising and presenting material in ways that reflect how people learn, and fostering motivation to engage with the material.4 It had been demonstrated that knowledge acquisition alone does not result in expertise.5 Individuals may successfully recall information and perform well on examinations, but they often encounter difficulties when addressing real-life clinical problems. The application of knowledge is critical, and hands-on clinical experience is invaluable. However, the tasks encountered in postgraduate medicine are more complex and challenging than those in traditional apprenticeships, rendering the ‘see one, do one, teach one’ method insufficient. Teaching methods that provide support and promote a deeper understanding of material are necessary to develop true expertise in medicine.6 The importance of such teaching methods underscores the critical need for faculty development—commonly referred to as training for trainers—which involves acquiring new skills and knowledge while undergoing a shift in mindset.
 
The Faculty Development Workgroup
Faculty development is central to the successful implementation of competency-based medical education. It includes activities undertaken by healthcare professionals to enhance teaching, leadership, research, and scholarly abilities in both individual and group contexts.7 This emphasis on faculty development was highlighted in the Position Paper on Postgraduate Medical Education, published in 2023.8 The Hong Kong Jockey Club Innovative Learning Centre for Medicine (ILCM), established by HKAM, was created to modernise postgraduate medical education in Hong Kong. Initially focused on simulation-based medical education, the ILCM has since broadened its scope to address all aspects of postgraduate medical education.9 Recognising the importance of faculty development, the ILCM has assumed a leading role in advocating for this concept within the medical community. To advance these efforts, the ILCM formed the Faculty Development Workgroup (the ‘Workgroup’), which includes representatives from all 15 Colleges under HKAM, to collaborate on faculty development initiatives.
 
To ensure that faculty development in postgraduate medical education is competency-based, the Workgroup conducted a literature review to identify existing frameworks and identified seven relevant models.10 11 12 13 14 15 16 After careful deliberation, the frameworks proposed by Hesketh et al12 and the Academy of Medical Educators16 were deemed the most comprehensive and appropriate for adaptation to the local context in Hong Kong.
 
The Faculty Development Framework of the Academy
Steinert7 defines faculty as all individuals involved in teaching and educating learners across the educational continuum (eg, undergraduate, graduate, postgraduate, and continuing professional development), leadership and management within universities, hospitals, and the community, as well as research and scholarship in the health professions (eg, communication sciences, dentistry, nursing, and rehabilitation sciences). Based on this definition, the Workgroup delineated four categories of faculty within the framework: trainers, examiners, supervisors of training, and collegial leads in medical education within each College of HKAM. The initial phase of development focused on creating the Framework for Faculty Development of Trainers, which outlines the key competencies required for trainers. This framework facilitates the identification of individual learning needs, supports effective delivery of course content, and guides the evaluation of outcomes of the faculty development programme.17
 
The Workgroup adopted the three-circle model to classify learning outcomes proposed by Simpson et al.18 This model categorises competencies into core tasks, approaches to tasks, and professional identity, ensuring that trainers perform their roles effectively while approaching these roles with appropriate attitudes and professionalism (Fig).18
 

Figure. Faculty Development Framework for Trainers based on the three-circle model18
 
Workshops and beyond for faculty development
The Framework for Faculty Development of Trainers17 was approved earlier this year by the Education Committee and the Council of HKAM (Fig). In the future, the ILCM will design and implement training workshops guided by the following principles19:
  • Evidence-informed educational design
  • Relevant content
  • Experiential learning with opportunities for practice and application
  • Opportunities for feedback and reflection
  • Intentional community building
  •  
    Moreover, a recent systematic review has highlighted key principles for effective faculty development that extend beyond workshops and individual teaching effectiveness. These principles include strengthening participants’ identities as educators, promoting recognition of educational excellence and leadership development, and fostering communities of practice to support ongoing learning and skill refinement.20 This comprehensive approach reflects the learning process for clinical skills, which requires practice, feedback, and continuous development in the workplace. Therefore, effective faculty development will require sustained support from HKAM and collaboration with stakeholders across all Colleges to ensure that faculty continue to advance their skills after completing workshops.
     
    Conclusion
    Faculty development is essential for the advancement of postgraduate medical education in Hong Kong. By equipping trainers with the appropriate competencies and skills, the framework ensures that doctors in training receive high-quality education and mentorship, ultimately enhancing patient care and outcomes within the healthcare system.6
     
    Author contributions
    All authors have contributed equally to the concept, development and critical revision of the manuscript. All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    All authors have declared no conflicts of interest.
     
    Funding/support
    This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    References
    1. Kohn LT, Corrigan JM, Donaldson MS, editors. To Err Is Human: Building a Safer Health System. Washington (DC): National Academies Press; 2000.
    2. Institute of Medicine (US) Committee on Quality of Health Care in America. Crossing the quality chasm: a new health system for the 21st century. Washington (DC): National Academies Press (US); 2001.
    3. Whitehead CR, Austin Z, Hodges BD. Flower power: the armoured expert in the CanMEDS competency framework? Adv Health Sci Educ Theory Pract 2011;16:681-94. Crossref
    4. Swanwick T, Forrest K, O’Brien BC, editors. Understanding Medical Education: Evidence, Theory, and Practice. The Association for the Study of Medical Education (ASME); 2019. Crossref
    5. Dreyfus SE, Dreyfus HL. A five-stage model of the mental activities involved in direct skill acquisition. Operations Research Center, University of California, Berkeley; 1980.
    6. So HY. Postgraduate medical education: see one, do one, teach one…and what else? Hong Kong Med J 2023;29:104. Crossref
    7. Steinert Y. Faculty development: core concepts and principles. In: Steinert Y, editor. Faculty Development in the Health Professions: A Focus on Research and Practice. Innovation and Change in Professional Education, 11. Dordrecht [NY]: Springer; 2014: 3-25. Crossref
    8. So HY, Li PK, Lai PB, et al. Hong Kong Academy of Medicine position paper on postgraduate medical education 2023. Hong Kong Med J 2023;29:448-52. Crossref
    9. Chen PP, So HY, Lo JS, Cheng BC. Modernising postgraduate medical education: evolving roles of the Hong Kong Jockey Club Innovative Learning Centre for Medicine in the Hong Kong Academy of Medicine. Hong Kong Med J 2023;29:480-3. Crossref
    10. Skeff KM, Stratos GA, Bergen MR, Regula DP Jr. A pilot study of faculty development for basic science teachers. Acad Med 1998;73:701-4. Crossref
    11. Harden RM, Crosby J. AMEE Guide No. 20: The good teacher is more than a lecturer—the twelve roles of the teacher. Med Teach 2000;22:334-47. Crossref
    12. Hesketh EA, Bagnall G, Buckley EG, et al. A framework for developing excellence as a clinical educator. Med Educ 2001;35:555-64. Crossref
    13. Molenaar WM, Zanting A, van Beukelen P, et al. A framework of teaching competencies across the medical education continuum. Med Teach 2009;31:390-6. Crossref
    14. Milner RJ, Gusic ME, Thorndyke LE. Perspective: toward a competency framework for faculty. Acad Med 2011;86:1204-10. Crossref
    15. Srinivasan M, Li ST, Meyers FJ, et al. “Teaching as a Competency”: competencies for medical educators. Acad Med 2011;86:1211-20. Crossref
    16. Academy of Medical Educators. Professional standards for medical, dental and veterinary educators (fourth edition). 2022. Available from: https://www.medicaleducators.org/write/MediaManager/Documents/AoME_Professional_Standards_4th_edition_1.0_(web_full_single_page_spreads).pdf. Accessed 1 Nov 2024.
    17. Hong Kong Academy of Medicine. Framework for Faculty Development Part 1: Trainers. September 2024. Available from: https://www.hkam.org.hk/sites/default/files/PDFs/2024/HKAM_Faculty%20Development%20Framework_Part%201.pdf?v=1729586789500. Accessed 20 Sep 2024.
    18. Simpson JG, Furnace J, Crosby J, et al. The Scottish doctor—learning outcomes for the medical undergraduate in Scotland: a foundation for competent and reflective practitioners. Med Teach 2002;24:136-43. Crossref
    19. Steinert Y, Mann K, Centeno A, et al. A systematic review of faculty development initiatives designed to improve teaching effectiveness in medical education: BEME Guide No. 8. Med Teach 2006;28:497-526. Crossref
    20. Steinert Y, Mann K, Anderson B, et al. A systematic review of faculty development initiatives designed to enhance teaching effectiveness: a 10-year update: BEME Guide No. 40. Med Teach 2016;38:769-86. Crossref

    Medical-social collaboration at Siu Lam Integrated Rehabilitation Services Complex

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    Medical-social collaboration at Siu Lam Integrated Rehabilitation Services Complex
    Karen KY Ho, MB, BS, FHKAM (Psychiatry)1; Winson CT Chan, MB, BS, MRCPsych1; Eric SK Lai, MSocSc2; Bonnie WM Siu, MB, ChB, FHKAM (Psychiatry)3; YS Ng, MB, ChB, FHKAM (Family Medicine)4; CL Lau, MB, BS, FHKAM (Emergency Medicine)5; Queenie Leung, MNurs (Clinical Leadership)1; YC Wong, MB, BS, FHKAM (Radiology)6
    1 Department of Psychiatry, Castle Peak Hospital, Hong Kong SAR, China
    2 Occupational Therapy Department, Castle Peak Hospital, Hong Kong SAR, China
    3 Castle Peak Hospital and Siu Lam Hospital, Hong Kong SAR, China
    4 Department of Family Medicine and Primary Health Care, Tuen Mun Hospital, Hong Kong SAR, China
    5 Department of Accident and Emergency, Pok Oi Hospital, Hong Kong SAR, China
    6 New Territories West Cluster, Hospital Authority, Hong Kong SAR, China
     
    Corresponding author: Dr Winson CT Chan (cct762@ha.org.hk)
     
     Full paper in PDF
     
    Background
    The Siu Lam Integrated Rehabilitation Services Complex (SLIRSC) is a newly established rehabilitation facility developed by the Social Welfare Department (SWD) on the former site of Siu Lam Hospital in Tuen Mun. It was created as part of the Chief Executive’s 2013 Policy Address initiatives for increasing subvented day and residential care placements for persons with disabilities.1 As the largest purpose-built rehabilitation facility in Hong Kong, the SLIRSC provides 1150 residential placements and 560 day-training placements for individuals in mental recovery, as well as those with intellectual and/or physical disabilities. It includes five residential care homes for persons with disabilities, which are operated by three non-governmental organisations (NGOs), namely, SAHK, Tung Wah Group of Hospitals, and New Life Psychiatric Rehabilitation Association.
     
    Challenges in medical service delivery
    The SLIRSC accommodates a large population of relatively advanced-age residents with multiple co-morbidities. As of 31 August 2024, the SLIRSC houses 567 residents, approximately one-third of whom are aged ≥60 years. Many residents require follow-up by various specialties, including 329 (58%) who require medical follow-up and 421 (74%) who require psychiatric follow-up. Despite its scenic natural landscape, the relatively remote location of the SLIRSC creates challenges when transporting residents to hospitals for medical care. Moreover, a substantial proportion of residents display mobility problems—more than one-fifth (21%) are either chairbound or bedbound. Some residents experience difficulty in adjusting to unfamiliar environments while they receive medical care outside the facility, leading to a need for more intensive care and supervision. These challenges emphasise the importance of an innovative medical-social collaboration model tailored to the unique requirements of the SLIRSC.
     
    Medical-social collaboration
    The World Health Organization has suggested that an integrated health service model, based on strong primary care and public health functions, can improve the distribution of health outcomes, enhance well-being, and increase quality of life.2 3 There is growing recognition of the need to integrate various health services to provide coordinated, patient-centred care.4 This integration can improve care quality, expand patient access to services, and reduce wait times for outpatient appointments.5 Notably, medical-social collaboration is one of the core strategies outlined in the World Health Organization Framework on integrated, people-centred health services.2 Collaboration is defined in various ways throughout the literature. Generally, it represents processes intended to improve efficiency and quality via synergistic combinations of resources and expertise from different organisations.6 7 This approach reduces duplication and facilitates the sharing of expertise and resources, enabling organisations to explore solutions beyond the limitations of their own perspectives.8 Medical-social collaboration is especially beneficial for populations with needs encompassing physical, mental, and social domains.9 Partnerships between the Hospital Authority (HA) and local NGOs are not new. As early as 2012, integrated medical and social support initiatives were already targeting and serving older adults in Hong Kong.10 Additional collaborative efforts include the Integrated Discharge Support Programme for high-risk older patients and the District Health Centres led by the Health Bureau.11 12
     
    The Committee for Service Implementation of the SLIRSC was established in 2023. The Committee is led by Dr YC Wong, Cluster Chief Executive of the New Territories West Cluster (NTWC) of the HA and Ms Maggie Leung, Assistant Director (Rehabilitation and Medical Social Services) of the SWD. It consists of stakeholders from the HA, SWD, and NGOs, which provides strategic direction and guidance regarding medical-social collaboration and support for the SLIRSC. A medical-social collaboration task force for the SLIRSC was created under the Committee to serve as a working platform for key stakeholders and facilitate collaboration among parties. Our medical-social collaboration model has three primary objectives: (1) streamline delivery of care, (2) enhance quality of care and services, and (3) improve backend efficiency.
     
    Streamlining delivery of care
    Considering the relatively remote location of the SLIRSC, our medical-social collaboration strives to facilitate on-site management, minimising the need for patient transport and admissions. To provide additional medical support, Yan Oi General Out-patient Clinic (GOPC), the clinic closest to the SLIRSC, has reserved appointment times for SLIRSC residents to manage episodic and chronic illnesses. The SLIRSC can make prior arrangements with the Yan Oi GOPC. Unused appointment times are released back to the general pool. The utilisation of these reserved appointment times increased from 2% in January 2024 to 24% in July 2024.
     
    Clustering follow-up appointments for residents through telehealth can mitigate distance barriers, conserve manpower, and reduce the time required for travel and transport.13 14 Specific telehealth workflows have been established by the Yan Oi GOPC and Tuen Mun Mental Health Centre, the psychiatric specialist out-patient clinic of Castle Peak Hospital, to facilitate case selection and delivery of care via telehealth. Telehealth has been used in the treatment of minor ailments, protocol-driven management, and follow-up of stable chronic illnesses. It is also utilised for initial case triage to reduce unnecessary attendance at the accident and emergency departments.
     
    Outbreak containment is important in any large-scale residential complex.15 The NTWC has collaborated with NGO operators to develop specific management guidelines for infectious disease outbreaks. Close surveillance is performed by the SLIRSC and NTWC, enabling early detection of infectious disease clusters and triggering necessary responses. Several communication platforms have been established between the NTWC and SLIRSC. Timely infection control guidance is provided by NTWC infection control team; face-to-face or telehealth consultations are arranged based on disease severity and symptomatology. In the event of a large-scale outbreak, the NTWC coordinates necessary medical support, admissions, and bed assignments in wards. This workflow has been activated twice (July 2024 and August 2024) to manage two coronavirus disease 2019 outbreaks, both of which were contained within a small area and for a limited duration.
     
    Enhancing quality of care and services
    A substantial number of SLIRSC residents require specialised nursing care. Our medical-social collaboration enhances the quality of care through the train-the-trainer programmes for new staff. These programmes focus on specialised nursing care, including management of the unique needs of residents with mental and intellectual disabilities and stoma care. Physiotherapists and occupational therapists from the NTWC also provide services through a hybrid mode, assisting local allied health professionals in delivering specialised on-site rehabilitation programmes.
     
    Due to the extensive impact of methicillin-resistant Staphylococcus aureus (MRSA) colonisation on the daily operations of the SLIRSC and provision of rehabilitation to residents, the NTWC has arranged MRSA decolonisation therapy for the SLIRSC. Prior training was provided to SLIRSC staff to enhance compliance. The programme began in June 2024 and the first group showed a success rate of 76% (16 of 21 MRSA carriers completed decolonisation and tested negative for MRSA upon re-evaluation). Successful cases will be de-labelled in the HA system. This training allows SLIRSC staff to continue on-site MRSA decolonisation therapy for carriers.
     
    Improving backend efficiency
    Increased efficiency is another primary goal of our collaboration. The SLIRSC is equipped with a state-of-the-art in-house medication management system. The NTWC facilitates the electronic transfer of dispensing data by supporting the input of dispensed medication information into their system. This system reduces administrative and medication errors, improves dispensing efficiency and medication safety, enhances productivity, and reduces the required manpower, saving both time and costs. A dedicated telehealth workflow for the SLIRSC further increases efficiency in medication collection after telehealth consultations, shortening wait times and conserving manpower within the SLIRSC.
     
    Summary
    As the largest purpose-built rehabilitation facility in Hong Kong, the SLIRSC offers a unique opportunity to re-orient our service model for residential homes by strengthening local medical-social collaboration. Thus far, outcomes have been promising; continuous review with collaborative efforts will further refine our service model, with the aim of promoting holistic care for persons with disabilities.
     
    Author contributions
    All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    All authors have disclosed no conflicts of interest.
     
    Acknowledgement
    The authors thank the following individuals and parties for their contributions to this article:
    1. Mr CC Law, Dr KM Cheng, Dr Jessica Wong and Mr WM Chung from Department of Psychiatry, Castle Peak Hospital;
    2. Dr Steve Tso from Department of Psychiatry, Siu Lam Hospital;
    3. Ms Mandy Mak from Department of Physiotherapy, Tuen Mun Hospital;
    4. Ms Pauline Chu from Department of Pharmacy, Tuen Mun Hospital;
    5. Ms Maggie Leung, Assistant Director (Rehabilitation and Medical Social Services) of Social Welfare Department;
    6. SAHK;
    7. Tung Wah Group of Hospitals; and
    8. New Life Psychiatric Rehabilitation Association.
     
    Funding/support
    This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    References
    1. Panel on Welfare Services, Legislative Council. Setting up of an Integrated Rehabilitation Services Complex at the site of ex–Siu Lam Hospital, Tuen Mun. 2014 Dec 8. Available from: https://www.legco.gov.hk/yr14-15/english/panels/ws/papers/ws20141208cb2-381-7-e.pdf. Accessed 2 Dec 2024.
    2. World Health Organization. Continuity and coordination of care: a practice brief to support implementation of the WHO Framework on integrated people-centred health services. World Health Organization; 2018.
    3. World Health Organization. Integrating health services: brief. World Health Organization; 2018.
    4. He AJ, Tang VF. Integration of health services for the elderly in Asia: a scoping review of Hong Kong, Singapore, Malaysia, Indonesia. Health Policy 2021;125:351-62. Crossref
    5. Baxter S, Johnson M, Chambers D, Sutton A, Goyder E, Booth A. The effects of integrated care: a systematic review of UK and international evidence. BMC Health Serv Res 2018;18:350. Crossref
    6. Axelsson R, Axelsson SB. Integration and collaboration in public health—a conceptual framework. Int J Health Plann Manage 2006;21:75-88. Crossref
    7. Woulfe J, Oliver TR, Zahner SJ, Siemering KQ. Multisector partnerships in population health improvement. Prev Chronic Dis 2010;7:A119.
    8. Huxham C, Vangen S. Managing to Collaborate: The Theory and Practice of Collaborative Advantage. Routledge; 2013. Crossref
    9. Fisher MP, Elnitsky C. Health and social services integration: a review of concepts and models. Soc Work Public Health 2012;27:441-68. Crossref
    10. Maw KC, Lo SV, Leung PY. Integrating medical and social support for elderly in Hong Kong—system and technology enabled service innovations. World Hosp Health Serv 2017;53:7-10.
    11. Lin FO, Luk JK, Chan TC, Mok WW, Chan FH. Effectiveness of a discharge planning and community support programme in preventing readmission of high-risk older patients. Hong Kong Med J 2015;21:208-16. Crossref
    12. Lin AF, Cunliffe C, Chu VK, et al. Prevention-focused care: the potential role of chiropractors in Hong Kong’s primary healthcare transformation. Cureus 2023;15:e36950. Crossref
    13. Groom LL, McCarthy MM, Stimpfel AW, Brody AA. Telemedicine and telehealth in nursing homes: an integrative review. J Am Med Dir Assoc 2021;22:1784-801.e7. Crossref
    14. Shigekawa E, Fix M, Corbett G, Roby DH, Coffman J. The current state of telehealth evidence: a rapid review. Health Aff (Millwood) 2018;37:1975-82. Crossref
    15. Lee MH, Lee GA, Lee SH, Park YH. Effectiveness and core components of infection prevention and control programmes in long-term care facilities: a systematic review. J Hosp Infect 2019;102:377-93. Crossref

    Empowering women’s health: a rising priority

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    Empowering women’s health: a rising priority
    Claire Chenwen Zhong, PhD, MPhil1,2 #; Junjie Huang, PhD, MSc1,2,3 #; Mellissa Withers, PhD, MHS4; Martin CS Wong, MD, MPH1,2,5
    1 Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    2 Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    3 Editor, Hong Kong Medical Journal
    4 Department of Population and Health Sciences, Institute for Global Health, University of Southern California, Los Angeles, United States
    5 Editor-in-Chief, Hong Kong Medical Journal
    # Equal contribution
     
    Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
     
     Full paper in PDF
     
    Introduction
    Women’s health differs from men’s health not only in biological and gender-specific aspects but also in societal and psychological dimensions, making it a crucial component of public health. The health of women and girls is particularly important because they often face disadvantages and vulnerabilities due to discrimination in many societies. In recent years, increased awareness of gender-specific health issues has underscored the need for comprehensive strategies to address women’s health concerns, including reproductive health, cancer prevention, and care for elderly women. This editorial provides an overview of the unique health challenges faced by women in Hong Kong throughout various stages of life and examines interventions designed to improve health outcomes for women.
     
    Reproductive health
    Reproductive health is fundamental to women’s overall well-being, encompassing all aspects of the reproductive system and its functions.1 Health issues may arise at any stage of life, from menarche (the onset of the first menstrual period) to menopause. Multiple pregnancies, defined as the simultaneous presence of more than one fetus (eg, twins, triplets, or higher-order multiples), involve serious health risks.2 3 The perinatal mortality risk can be up to 7 times higher in twin pregnancies than in singleton pregnancies; risks increase further in triplet and quadruplet pregnancies.2 Since the introduction of assisted reproductive technology in 1978, the prevalence of multiple pregnancies has risen worldwide.2 A retrospective study analysing medical records from a university tertiary obstetric unit in Hong Kong showed that the prevalence of multiple pregnancies increased from 1.41% in the first decade (2000-2010) to 1.91% in the second decade (2010-2019).2 Despite this increase, the total mortality rate for multiple births significantly decreased, from 25.32 per 1000 births to 13.82 per 1000 births. This improvement has been attributed to advancements in antenatal care, enhanced treatment options, and reductions in preterm births.2 These findings highlight the importance of continued research and targeted interventions in reproductive health to achieve better outcomes for women and infants.
     
    Additionally, postpartum haemorrhage (PPH), a life-threatening condition characterised by excessive bleeding, is significantly more common in women with multiple pregnancies than in those with singleton pregnancies.4 A retrospective cohort study revealed a substantially elevated risk of severe PPH among women with twin pregnancies, particularly those who were obese, had conceived via in vitro fertilisation, or presented with placenta previa.4 Special attention must be given to pregnant women with these risk factors, including proactive preparations for the management of severe PPH to mitigate the risk of mortality. Enhanced monitoring and targeted interventions are essential for efforts to improve outcomes in this vulnerable population. Psychological morbidity is also frequently observed in pregnant women, particularly those experiencing threatened miscarriage.5 In a cross-sectional study of women in their first trimester, 48.4% to 76.7% reported distress.5 Notably, women with a history of miscarriage exhibited higher stress scores relative to those without such a history.5 6 Thus, early identification of women requiring additional psychological support, facilitated through psychometric instruments, is critical for improvements to maternal psychological well-being, which is also associated with better fetal outcomes.5
     
    Moreover, pregnant women tend to be more vulnerable to communicable diseases such as coronavirus disease 2019 (COVID-19), more concerned about severe complications, and more fearful of vertical transmission to neonates; these tendencies impose additional psychological stress.7 8 According to a cross-sectional survey conducted in Hong Kong from 28 July 2020 to 13 August 2020, 83.1% of pregnant women expressed substantial concern about contracting COVID-19 during pregnancy, 70.5% feared intrauterine viral infection of their fetuses due to maternal COVID-19, and 84.3% opposed the ban on husbands accompanying their wives during labour and delivery.7 Governments and healthcare professionals should enhance public education to increase awareness of COVID-19—related complications during pregnancy, enabling women to approach the situation with informed perspectives and reducing unnecessary stress.7 The provision of universal screening for pregnant women, a widely supported approach, represents another intervention to alleviate the burden of disease.7
     
    In addition to health concerns during pregnancy, infertility remains a major reproductive health issue for women, affecting nearly one in six adult women worldwide.9 Although advancements in fertility preservation technologies have enabled many patients to conceive their own biological children, some individuals have been unable to undergo the ovarian stimulation required for oocyte or embryo freezing, including prepubertal girls who are ineligible for the procedure.10 Ovarian tissue cryopreservation serves as an ideal option for preserving fertility in these cases.11 An in vivo study of nude mice demonstrated that grafted ovarian tissues remained viable after ovarian tissue cryopreservation and subsequent transplantation, supporting the implementation of this approach in Hong Kong.11
     
    Cancer and ageing
    Cancer is a leading cause of death among women, and breast cancer is the most prevalent type in Hong Kong.12 13 Early detection through risk-based screening programmes is essential for reducing breast cancer–related morbidity and mortality.14 15 In Hong Kong, the Cancer Expert Working Group on Cancer Prevention and Screening has reviewed and updated its breast cancer screening recommendations, introducing slight changes for women at moderate risk.12 Women aged 44 to 69 years with increased breast cancer risk (eg, family history, benign breast disease, reproductive history, early menarche, high body mass index, and physical inactivity) are advised to consider biennial mammography screening after consulting their physicians.12
     
    Advanced treatment plays an equally important role in managing breast cancer.16 Neoadjuvant chemotherapy (NAC), administered before definitive breast cancer surgery, reduces tumour size and facilitates surgery for patients.17 Insights from a 12-year review of the Hong Kong Breast Cancer Registry demonstrated the effectiveness of NAC, supporting its application in patients with stage II or higher disease, as well as those with human epidermal growth factor receptor 2–positive (non-luminal) or triple-negative breast cancers.16 The use of NAC in Hong Kong nearly doubled during the 12-year period, increasing from 5.6% in 2006-2011 to 10.3% in 2012-2017.16
     
    Early prevention of cancer through human papillomavirus (HPV) vaccination plays an indispensable role in women’s health. Human papillomavirus vaccination is a safe and effective method for preventing cervical cancer, as well as other HPV-related cancers, including cancers of the anus, vulva, vagina, penis, and oropharynx.18 To improve vaccine coverage, the promotion of a gender-neutral vaccination programme within the school-based childhood immunisation framework is essential. A cross-sectional online survey in Hong Kong revealed that only 12.5% (63/503) of parents had consented to vaccination for their daughters.18 Parental misconceptions regarding vaccine safety and the ideal vaccination age represent major barriers that must be addressed to increase HPV vaccination coverage among children.18
     
    As women age, they encounter unique health challenges, including an increased risk of osteoporosis, cardiovascular disease, and cognitive decline. Pelvic organ prolapse (POP) is a common health issue, reported by nearly 10% of the Chinese population.19 Increasing evidence supports surgical treatment over vaginal pessaries as a definitive intervention for POP. A recent multicentre retrospective study showed that POP surgeries were safe and effective for women aged ≥75 years in Hong Kong.20 Additionally, there is a need to emphasise the importance of the Hong Kong Reference Frameworks in managing chronic diseases among elderly women.21 These frameworks provide evidence-based, standardised guidelines for primary healthcare professionals to assist patients in preventing and managing conditions such as diabetes mellitus, hypertension, and common musculoskeletal disorders.21
     
    In summary, the growing recognition of women’s health as a critical component of public health requires a comprehensive, evidence-based approach to implementing effective interventions that address the unique challenges faced by women at various life stages. This editorial has outlined prevalent health issues among women in Hong Kong and worldwide, emphasising the need for a multidimensional framework that integrates prevention, early detection, and effective treatment. Such an approach is essential to improve women’s health outcomes in the future.
     
    Author contributions
    All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    All authors have disclosed no conflicts of interest.
     
    Acknowledgement
    The authors acknowledge the literature search and review assistance of Mr Zehuan Yang, Research Assistant at the Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong.
     
    References
    1. Global Perspectives on Women’s Sexual and Reproductive Health Across the Lifecourse. Cambridge International Law Journal; 2018.
    2. Lau SL, Wong ST, Tse WT, et al. Perinatal mortality rate in multiple pregnancies: a 20-year retrospective study from a tertiary obstetric unit in Hong Kong. Hong Kong Med J 2022;28:347-56. Crossref
    3. Sherer DM. Adverse perinatal outcome of twin pregnancies according to chorionicity: review of the literature. Am J Perinatol 2001;18:23-37. Crossref
    4. Kong CW, To WW. Risk factors for postpartum haemorrhage in twin pregnancies and haemorrhage severity. Hong Kong Med J 2023;29:295-300. Crossref
    5. Ip PN, Ng K, Wan OY, Kwok JW, Chung JP, Chan SS. Cross-sectional study to assess the psychological morbidity of women facing possible miscarriage. Hong Kong Med J 2023;29:498-505. Crossref
    6. Farren J, Jalmbrant M, Ameye L, et al. Post-traumatic stress, anxiety and depression following miscarriage or ectopic pregnancy: a prospective cohort study. BMJ Open 2016;6:e011864. Crossref
    7. Lok WY, Chow CY, Kong CW, To WW. Knowledge, attitudes, and behaviours of pregnant women towards COVID-19: a cross-sectional survey. Hong Kong Med J 2022;28:124-32. Crossref
    8. Dashraath P, Wong JL, Lim MX, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020;222:521-31. Crossref
    9. World Health Organization. 1 in 6 people globally affected by infertility: WHO. Last modified April 4, 2023. Available from: https://www.who.int/news/item/04-04-2023-1-in-6-people-globally-affected-by-infertility. Accessed 12 Dec 2024.
    10. Dolmans MM, Donnez J. Fertility preservation in women for medical and social reasons: oocytes vs ovarian tissue. Best Pract Res Clin Obstet Gynaecol 2021;70:63-80. Crossref
    11. Chung JP, Chan DY, Song Y, et al. Implementation of ovarian tissue cryopreservation in Hong Kong. Hong Kong Med J 2023;29:121-31. Crossref
    12. Tsang TH, Wong KH, Allen K, et al. Update on the Recommendations on Breast Cancer Screening by the Cancer Expert Working Group on Cancer Prevention and Screening. Hong Kong Med J 2022;28:161-8. Crossref
    13. Huang J, Chan PS, Lok V, et al. Global incidence and mortality of breast cancer: a trend analysis. Aging (Albany NY) 2021;13:5748-803. Crossref
    14. Duffy S, Vulkan D, Cuckle H, et al. Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT. Health Technol Assess 2020;24:1-24. Crossref
    15. Henderson JT, Webber EM, Weyrich MS, et al. Screening for breast cancer: evidence report and systematic review for the US Preventive Services Task Force. JAMA 2024;331:1931-46. Crossref
    16. Chan YH, Kwok CC, Tse DM, Lee HM, Tam PY, Cheung PS. Preoperative considerations and benefits of neoadjuvant chemotherapy: insights from a 12-year review of the Hong Kong Breast Cancer Registry. Hong Kong Med J 2023;29:198-207. Crossref
    17. Shien T, Iwata H. Adjuvant and neoadjuvant therapy for breast cancer. Jpn J Clin Oncol 2020;50:225-9. Crossref
    18. Lam EW, Ngan HY, Kun KY, Li DF, Wan WY, Chan PK. Awareness, perceptions, and acceptance of human papillomavirus vaccination among parents in Hong Kong. Hong Kong Med J 2023;29:287-94. Crossref
    19. Pang H, Zhang L, Han S, et al. A nationwide population-based survey on the prevalence and risk factors of symptomatic pelvic organ prolapse in adult women in China—a pelvic organ prolapse quantification system-based study. BJOG 2021;128:1313-23. Crossref
    20. Wong D, Lee YT, Tang GP, Chan SS. Surgical treatment of pelvic organ prolapse in women aged ≥75 years in Hong Kong: a multicentre retrospective study. Hong Kong Med J 2022;28:107-15. Crossref
    21. Health Bureau, Primary Healthcare Commission. Reference Frameworks. Available from: https://www.healthbureau.gov.hk/phcc/main/frameworks.html?lang=2. Accessed 24 Nov 2024.

    Hepatitis B screening to reduce liver cancer burden

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    Hepatitis B screening to reduce liver cancer burden
    Claire Chenwen Zhong, MPhil, PhD1,2; Wanghong Xu, MD, PhD3,4; Junjie Huang, MSc, PhD1,2,5; Martin CS Wong, MD, MPH1,2,5,6
    1 The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    2 Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    3 International Editorial Advisory Board, Hong Kong Medical Journal
    4 School of Public Health, Fudan University, Shanghai, China
    5 Editor, Hong Kong Medical Journal
    6 Editor-in-Chief, Hong Kong Medical Journal
     
    Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
     
     Full paper in PDF
     
    Epidemiology of liver cancer and hepatitis B infection
    According to the 2021 statistics from the Hong Kong Cancer Registry, liver cancer is the fifth most commonly diagnosed cancer and the third leading cause of cancer-related mortality in Hong Kong.1 Over the past few decades, the incidence of liver cancer in Hong Kong has exhibited an exceptionally declining trend, consistent with the overall decrease observed across Eastern Asia.2 3 4 5 However, the number of new liver cancer cases in Hong Kong has been increasing, primarily due to the ageing population.2 3 In addition to the heightened risk of liver cancer among older individuals, prognosis is often worsened by increased liver fragility and the presence of co-morbidities.6
     
    Hepatocellular carcinoma (HCC) is the predominant histological type of liver cancer, causing the majority of liver cancer diagnoses and deaths.7 8 Cirrhosis of the liver precedes HCC development in most cases, acting as a driver through hepatocyte regeneration.9 10 Among the various causes of cirrhosis, chronic hepatitis B infection is the leading contributor to HCC.11 The hepatitis B virus (HBV) infects only primates and can cause hepatocellular injury by damaging infected hepatocytes.12 Moreover, HBV exhibits oncogenic potential by inducing genomic instability through its integration into the host genome.12 Other risk factors for HCC include chronic hepatitis C virus (HCV) infection, dietary exposure to aflatoxin, excessive alcohol consumption, obesity, type 2 diabetes, and smoking.2 However, the burden of liver cancer in Hong Kong is unlikely to be linked to HCV or aflatoxin exposure, considering the low prevalence of HCV and the rarity of aflatoxin contamination over the past decade.13 14
     
    The endemicity of hepatitis B in Hong Kong has declined from high-intermediate to intermediate-low, with a significant reduction in seroprevalence of hepatitis B surface antigen (HBsAg) among various populations, including new blood donors and pregnant women.15 This success can be attributed to the implementation of a universal hepatitis B vaccination programme in 1988 for all newborns and the availability of antiviral treatments. Since the initiation of the vaccination programme, coverage of the third dose of the hepatitis B vaccine in children aged 3 to 5 years has consistently exceeded 99%.16 However, adults over the age of 30 years were not included in the universal neonatal hepatitis B vaccination programme; these individuals remain at high risk of hepatitis B infection because they lack immunological protection.2 A recent study estimated that the overall HBsAg seroprevalence in Hong Kong remains as high as 7.2%.13 Therefore, a subsidised screening programme is urgently needed to protect the unvaccinated population from the risks of hepatitis B infection and liver cancer.
     
    Existing screening practices and their challenges
    Worldwide, the epidemiology of liver cancer is shifting due to expanded vaccination coverage for HBV and HCV, increasing prevalences of chronic diseases, and growing numbers of smokers and individuals consuming excessive amounts of alcohol.17 18 According to a global analysis,18 liver cancer was responsible for 529 202 new cases, 483 875 deaths, and 12.9 million disability-adjusted life years in 2021. These figures represent approximately 26% and 25% increases in liver cancer incidence and mortality, respectively, from 2010 to 2021.18 In 2021, the majority of liver cancer deaths were attributed to HBV (38%), followed by HCV (30%), alcohol (19%), metabolic dysfunction–associated steatotic liver disease (9%), and other causes (4%).18
     
    The global burden of HBV remains substantial, with an estimated HBsAg prevalence of 3.9% in 2016, corresponding to nearly 291 million infections.19 However, only 10% (29 million) of these infections were diagnosed, and just 5% (4.8 million of 94 million eligible individuals) received antiviral therapy.19 The absolute number of liver cancer cases due to hepatitis B increased by 21%, and associated deaths rose by 17% from 2010 to 2021 globally.20 The global age-standardised incidence rate for liver cancer due to hepatitis B declined, with an annual percentage change of -0.60% (95% uncertainty interval: -0.69% to -0.51%); the age-standardised death rate also decreased, with an annual percentage change of -0.98% (95% uncertainty interval: -1.24% to -0.72%).18
     
    To reduce the prevalence and burden of HBV infection, two primary screening strategies have been proposed and implemented in various countries: universal screening and screening in higher-prevalence settings. In the United States, the Centers for Disease Control and Prevention updated its guidelines in 2023, recommending hepatitis B screening using three laboratory tests at least once in a lifetime for adults aged ≥18 years.21 Prior to this update, hepatitis B screening was recommended only for pregnant women and populations at increased risk of chronic HBV infection.21 This policy change was informed by a study demonstrating the cost-effectiveness of universal screening, particularly in settings with an undiagnosed chronic hepatitis B prevalence of 0.24% and annual antiviral treatment costs below US$894.22 Universal screening also simplifies implementation by eliminating complex risk stratification, which is challenging for healthcare workers to effectively implement in real-world settings.22 Conversely, targeted screening may be more cost-effective in settings where the prevalence of undiagnosed HBsAg is very low (<0.026%), often achievable through universal neonatal vaccination and high screening coverage.22 Targeted screening also requires fewer resources, making it more feasible in resource-limited contexts.22
     
    Proposed programme overview
    In the 2024 Policy Address, the Hong Kong Government announced plans to introduce a subsidised hepatitis B screening programme to prevent liver cancer.23 Under this programme, District Health Centres and family doctors will provide risk-based hepatitis B screening and management through strategic purchasing.23 The initiative aims to support Hong Kong in achieving the World Health Organization’s viral hepatitis elimination goals24 by increasing awareness among individuals unaware of their HBV infection. The programme will involve Hong Kong’s 18 District Health Centres, which will offer simple blood tests. Family doctors will follow up with hepatitis B carriers, ensuring consistent monitoring for this chronic and often asymptomatic condition, which can persist for 20 to 30 years.23 The programme will adopt a risk-based screening approach, initially offering free screening to individuals with elevated risk of HBV infection, such as family members of hepatitis B patients, and subsequently expanding to other adults.25 Additional high-risk groups, including people who inject drugs, individuals with human immunodeficiency virus, men who have sex with men, sex workers, and prison inmates, will be prioritised for testing.25 Screening may also target specific age-groups to more effectively reduce severe morbidity and mortality.
     
    Benefits of the proposed programme
    The proposed programme offers several advantages. First, it will improve access to screening for individuals at high risk of HBV infection, addressing resource constraints in Hong Kong’s healthcare system while enhancing clinical outcomes by prioritising vulnerable populations. Second, the programme has the potential to reduce liver cancer rates through early detection and intervention. Considering the strong association between HBV infection and liver cancer, this initiative could significantly alleviate the burden of both conditions. Finally, the programme will strengthen community healthcare by identifying at-risk individuals early, preventing progression to more severe disease, and reducing strain on the healthcare system.
     
    Implementation considerations
    Before implementing the proposed hepatitis B screening programme, three critical aspects must be carefully addressed and optimised to ensure its success.
     
    First, it is essential to assess and address the training needs of healthcare providers. The shortage of healthcare professionals in Hong Kong, combined with increasing healthcare demand, has led to prolonged waiting times for medical services.26 To enhance implementation readiness, targeted and comprehensive training programmes should be developed and delivered to healthcare providers prior to the programme’s launch. This training should focus on equipping providers with the necessary knowledge, skills, and workflows to ensure the programme’s efficiency and effectiveness while minimising disruptions to existing services.
     
    Second, increased public awareness of hepatitis B is vital for efforts to achieve high participation rates in the screening programme. A 2010 telephone survey revealed suboptimal public awareness of hepatitis B in Hong Kong; approximately 45% of respondents were unaware that hepatitis B is the leading cause of chronic viral hepatitis, and 73% mistakenly believed that the virus could be transmitted by consuming contaminated seafood.27 Similarly, a 2020 study identified persistent deficiencies in knowledge, attitudes and behaviours regarding viral hepatitis, as well as low screening rates, highlighting the need for comprehensive educational initiatives.28 These initiatives should utilise evidence-based strategies to correct misconceptions, enhance risk awareness, and promote positive health-seeking behaviours, consistent with the World Health Organization’s viral hepatitis elimination targets.28
     
    Finally, robust evaluation mechanisms should be established to monitor and assess the programme’s implementation and outcomes. Key metrics can include the proportion of the target population screened relative to the estimated need and the programme’s cost-effectiveness, measured by comparing cost savings from early detection and treatment with total programme expenditures. Implementation science frameworks, such as process evaluation and logic models, can be established to identify barriers, facilitators, and contextual factors influencing outcomes. This approach facilitates ongoing refinement and scalability of the programme. A structured three-phase approach is recommended to develop effective implementation strategies. In the first phase, qualitative studies using the Consolidated Framework for Implementation Research can identify obstacles and facilitators to implementation.29 The second phase involves designing tailored strategies based on the Consolidated Framework for Implementation Research-linked Expert Recommendations for Implementing Change to address barriers and enhance facilitators.30 In the third phase, these strategies can be evaluated and refined through consensus-building methods, such as Delphi techniques.31
     
    Conclusion
    The rising burden of liver cancer, largely attributable to chronic hepatitis B infection, emphasises the pressing need for robust screening and prevention strategies. The proposed subsidised hepatitis B screening programme aims to identify at-risk individuals and facilitate early detection, ultimately reducing the community’s liver cancer burden. By leveraging the resources of District Health Centres and family doctors, the programme seeks to enhance public awareness and expand access to screening, particularly for high-risk populations. Efforts to ensure adequate training for healthcare providers and improve public education regarding hepatitis B will be central to the programme’s success. Based on careful planning, implementation, and evaluation, this initiative has the potential to substantially advance Hong Kong’s progress toward achieving the World Health Organization’s viral hepatitis elimination targets.
     
    Author contributions
    All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    All authors have disclosed no conflicts of interest.
     
    Funding/support
    This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    Acknowledgement
    The authors acknowledge the assistance of Mr Zehuan Yang, Research Assistant at The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, for his support with the literature search and review.
     
    References
    1. Hong Kong Cancer Registry, Hospital Authority. Top ten cancers. 2021. Available from: https://www3.ha.org.hk/cancereg/topten.html. Accessed 6 Nov 2024.
    2. Ma T, Wei X, Wu X, Du J. Trends and future projections of liver cancer incidence in Hong Kong: a population-based study. Arch Public Health 2023;81:179. Crossref
    3. Huang J, Lok V, Ngai CH, et al. Disease burden, risk factors, and recent trends of liver cancer: a global country-level analysis. Liver Cancer 2021;10:330-45. Crossref
    4. Huang J, Lucero-Prisno DE 3rd, Zhang L, et al. Updated epidemiology of gastrointestinal cancers in East Asia. Nat Rev Gastroenterol Hepatol 2023;20:271-87. Crossref
    5. Wong MC, Huang JL, George J, et al. The changing epidemiology of liver diseases in the Asia-Pacific region. Nat Rev Gastroenterol Hepatol 2019;16:57-73. Crossref
    6. Macias RI, Monte MJ, Serrano MA, et al. Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics. Aging (Albany NY) 2021;13:23416-34. Crossref
    7. McGlynn KA, Petrick JL, El-Serag HB. Epidemiology of hepatocellular carcinoma. Hepatology 2021;73 Suppl 1:4-13. Crossref
    8. Choi CK, Ho CH, Wong MY, et al. Efficacy, toxicities, and prognostic factors of stereotactic body radiotherapy for unresectable liver metastases. Hong Kong Med J 2023;29:105-11. Crossref
    9. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006;45:529-38. Crossref
    10. Wong MC, Huang J. The growing burden of liver cirrhosis: implications for preventive measures. Hepatol Int 2018;12:201-3. Crossref
    11. Bialecki ES, Di Bisceglie AM. Clinical presentation and natural course of hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2005;17:485-9. Crossref
    12. Hsu YC, Huang DQ, Nguyen MH. Global burden of hepatitis B virus: current status, missed opportunities and a call for action. Nat Rev Gastroenterol Hepatol 2023;20:524-37. Crossref
    13. Liu KS, Seto WK, Lau EH, et al. A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong. J Infect Dis 2019;219:1924-33. Crossref
    14. Yau AT, Chen MY, Lam CH, Ho YY, Xiao Y, Chung SW. Dietary exposure to mycotoxins of the Hong Kong adult population from a Total Diet Study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2016;33:1026-35. Crossref
    15. Lok WY, Kong CW, To WW. Prevalence of hepatitis B carrier status and its negative association with hypertensive disorders in pregnancy. Obstet Gynecol Int 2021;2021:9912743. Crossref
    16. Viral Hepatitis Control Office; Centre for Health Protection; Department of Health, Hong Kong SAR Government. Serologic testing after hepatitis B vaccination for babies born to mothers infected with hepatitis B virus. December 2021. Available from: https://www.hepatitis.gov.hk/english/health_professionals/files/PVST_website.pdf. Accessed 12 Dec 2024.
    17. Huang DQ, Singal AG, Kono Y, Tan DJ, El-Serag HB, Loomba R. Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer. Cell Metab 2022;34:969-77.e2. Crossref
    18. Tan EY, Danpanichkul P, Yong JN, et al. Liver cancer in 2021: Global Burden of Disease Study. J Hepatol 2024 Oct 29. Epub ahead of print. Crossref
    19. Polaris Observatory Collaborators. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol 2018;3:383-403. Crossref
    20. Liu Z, Jiang Y, Yuan H, et al. The trends in incidence of primary liver cancer caused by specific etiologies: results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention. J Hepatol 2019;70:674-83. Crossref
    21. Conners EE, Panagiotakopoulos L, Hofmeister MG, et al. Screening and testing for hepatitis B virus infection: CDC recommendations—United States, 2023. MMWR Recomm Rep 2023;72:1-25. Crossref
    22. Toy M, Hutton D, Harris AM, Nelson N, Salomon JA, So S. Cost-effectiveness of 1-time universal screening for chronic hepatitis B infection in adults in the United States. Clin Infect Dis 2022;74:210-7. Crossref
    23. Hong Kong SAR Government. The Chief Executive’s 2024 Policy Address. 2024. Available from: https://www.policyaddress.gov.hk/2024/public/pdf/policy/policy-full_en.pdf. Accessed 18 Nov 2024.
    24. World Health Organization. Hepatitis. Elimination of hepatitis by 2030. Available from: https://www.who.int/health-topics/hepatitis/elimination-of-hepatitis-by-2030#tab=tab_1. Accessed 12 Dec 2024.
    25. Viral Hepatitis Control Office, Department of Health, Hong Kong SAR Government. Focused risk-based testing for chronic hepatitis B virus infection. July 2022. Available from: https://www.hepatitis.gov.hk/english/ health_professionals/files/iCE_focused_risk_based_HBV_ testing_web.pdf. Accessed 12 Dec 2024.
    26. Schoeb V. Healthcare service in Hong Kong and its challenges. The role of health professionals within a social model of health. China Perspect 2016;4:51-8. Crossref
    27. Leung CM, Wong WH, Chan KH, et al. Public awareness of hepatitis B infection: a population-based telephone survey in Hong Kong. Hong Kong Med J 2010;16:463-9.
    28. Chan HL, Wong GL, Wong VW, Wong MC, Chan CY, Singh S. Questionnaire survey on knowledge, attitudes, and behaviour towards viral hepatitis among the Hong Kong public. Hong Kong Med J 2022;28:45-53. Crossref
    29. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci 2009;4:50. Crossref
    30. Powell BJ, Waltz TJ, Chinman MJ, et al. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci 2015;10:21. Crossref
    31. Holey EA, Feeley JL, Dixon J, Whittaker VJ. An exploration of the use of simple statistics to measure consensus and stability in Delphi studies. BMC Med Res Methodol 2007;7:52. Crossref

    COVID-19 responses in vulnerable populations: from clinical management to healthcare policies

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    COVID-19 responses in vulnerable populations: from clinical management to healthcare policies
    Harry HX Wang, PhD1,2,3; Vivian Yawei Guo, PhD2; Yao-jie Xie, PhD4,5,6; Yu-ting Li, MPH7; Junjie Huang, PhD1,8; Martin CS Wong, MD, MPH8,9,10,11,12
    1 Editor, Hong Kong Medical Journal
    2 School of Public Health, Sun Yat-Sen University, Guangzhou, China
    3 Baoan Central Hospital of Shenzhen, Shenzhen, China
    4 School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China
    5 Joint Research Centre for Primary Health Care, The Hong Kong Polytechnic University, Hong Kong SAR, China
    6 Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China
    7 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China
    8 Centre for Health Education and Health Promotion, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    9 Editor-in-Chief, Hong Kong Medical Journal
    10 School of Public Health, Fudan University, Shanghai, China
    11 The Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    12 School of Public Health, Peking University, Beijing, China
     
    Corresponding author: Prof Martin CS Wong (wong_martin@cuhk.edu.hk)
     
     Full paper in PDF
     
    Healthcare for vulnerable populations, including but not limited to children, women (particularly during pregnancy), older adults, individuals with underlying long-term conditions, and those facing structural barriers associated with lower socio-economic status, remains one of the most formidable challenges in health protection and promotion worldwide. The advent of coronavirus disease 2019 (COVID-19) has exacerbated the vulnerability of these groups, placing them at greater risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and worse health outcomes.1 Global data indicate that COVID-19 has disproportionately affected these vulnerable groups, driven by a complex interplay of biological factors, social determinants, and overstretched healthcare services.2
     
    A substantial body of evidence demonstrates the harmful and long-lasting consequences of COVID-19 on the development of children and adolescents, encompassing physical health, mental well-being, academic performance, and socio-emotional skills, both directly and indirectly.3 A recent review of the literature revealed that adolescents, children from ethnic minority backgrounds or lower-income families, and those with obesity were more susceptible to SARS-CoV-2 infection.4 While COVID-19 generally presents as a milder or moderate illness in children compared to adults, due to fundamental differences in immune responses, continued surveillance—such as wastewater monitoring and universal or pooled testing—remains critical to managing the spread of infection within communities.4 Serious conditions, although fortunately rare, require preparedness and response efforts from frontline paediatricians and intensivists to provide optimal respiratory support. A framework for airway management procedures has been proposed, based on a comprehensive system incorporating respiratory pattern monitoring, spontaneous respiration oxygenation, apnoeic oxygenation, manual ventilation, and scavenging to reduce the risk of healthcare-associated transmission.5 Case reports have described adolescent patients presenting with rare conditions, such as laboratory-confirmed SARS-CoV-2 infection with chilblain-like lesions6 and paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 after recovery from COVID-19.7 Both cases suggest that paediatricians should remain vigilant for potential symptoms and signs to enable timely diagnosis and mitigate transmission risks.
     
    Although vaccination has proven effective in reducing the severity of COVID-19 and providing protection against post—COVID-19 conditions, increasing concerns persist regarding the knowledge gap on long-term efficacy and potential adverse events associated with COVID-19 vaccines.4 8 Gut microbiota may play an important role in the immune response to vaccination, offering a promising avenue for management of vaccine-related adverse effects. A pilot study in Hong Kong demonstrated the safety and tolerability of a microbiota-derived health supplement among children aged 5 to 17 years.8 This supplement, administered prior to COVID-19 vaccination and continued for 7 days post-vaccination, showed potential for alleviating vaccine hesitancy among parents and children.8
     
    The impacts of COVID-19 on the dramatically increased use of digital tools in school education have also attracted considerable public attention, partly due to mitigation strategies such as school closures and restrictions, which have affected at least half of the global student population.9 Despite rapid advances in virtual learning technology and home-schooling platforms, the prolonged reliance on remote or distance learning in response to the COVID-19 pandemic poses profound risks to the cognitive and social development of adolescents. These risks arise from the absence of physical interactions with peers and teachers during the transition to adulthood.9 Such effects may be more pronounced in children and youth with behavioural or intellectual disabilities who rely on special education support services. In resource-constrained settings or among low-income families, effective education time is often substantially reduced due to inadequate access to electronic devices and limited internet connectivity, thereby exacerbating academic inequality. Addressing this challenge may require sustained government investment in community-based, targeted socio-technical interventions to close the social class achievement gaps and reduce the digital divide.10
     
    Excessive screen time resulting from increased reliance on digital media has led to a range of public health concerns, including asthenopia and vision impairment. A clinical assessment of visual acuity among school-aged adolescents in western rural China revealed a significantly higher prevalence of asthenopia and worsened vision impairment during the COVID-19 pandemic compared with the pre-pandemic period.11 The striking progression of vision impairment highlights the urgent need for policymakers to develop system-level strategies and tailored guidelines aimed at promoting healthy screen time practices. Such measures are essential to address the increasing incidence of eye problems among students in the post—COVID-19 era, where digital media is deeply embedded in nearly every aspect of adolescents’ daily lives.
     
    Coronavirus disease 2019 also posed multiple challenges throughout pregnancy because pregnant women infected with the virus faced a higher risk of severe illness relative to their non-pregnant counterparts.12 Additionally, they may experience exacerbation of COVID-19 symptoms due to reduced lung capacity associated with fetal growth and immune suppression during pregnancy.13 Although compelling evidence indicates that rigorous public health measures effectively mitigate the spread of SARS-CoV-2,14 pregnant women often exhibited high levels of anxiety about contracting COVID-19, largely due to their vulnerable immune status.15 This widespread anxiety may arise from perceived risks of pregnancy complications, fears of vertical transmission to the newborn, and uncertainties regarding delivery and breastfeeding practices in the event of infection.15 These observations highlight the importance of ensuring enhanced laboratory support for universal screening and providing adequate personal protective equipment. Emotional support is equally important. Satisfaction with maternity care can be achieved through partner companionship during labour.15 A multidisciplinary approach involving expert teams has proven essential in providing optimal care.12 However, changes to childbirth companionship and peripartum services during the COVID-19 pandemic frequently fell short of pregnant women’s expectations, potentially leading to negative psychological consequences such as heightened antenatal anxiety and emotional disturbance.16 Guidelines and decision-making in obstetric practice must balance infection control measures with the peripartum needs of women; the nulliparous group requires additional attention.
     
    Older patients with COVID-19 are considered among the most vulnerable groups during the pandemic because advanced age and co-morbidities are well-documented risk factors for mortality.17 Clinical findings have supported frailty screening as a reliable predictor of clinical deterioration and adverse outcomes in older patients upon hospital admission.17 Furthermore, older adults were more likely to remain at home during the pandemic, with limited access to recreational activities or social support, while facing an increased risk of elder abuse.18 Tackling these issues may require government-led legislation and integrated social welfare services to reduce vulnerability to abuse and neglect among older adults, particularly those residing in long-term care facilities.19
     
    A recent global review examined national plans and policies on maternal, newborn, child, and adolescent health services, as well as health services for older people across 110 countries.20 The findings revealed a significant knowledge gap, particularly regarding the absence of specific activities, monitoring indicators, or resource allocations aimed at mitigating potential service disruptions in the COVID-19 response and recovery plans. The insights gained from clinical management during this pandemic will undoubtedly inform the development of policy interventions and guide future interdisciplinary research to enhance preparedness for emerging and unforeseen public health challenges, ultimately improving health outcomes for vulnerable populations.
     
    Author contributions
    All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    Conflicts of interest
    All authors have declared no conflict of interest.
     
    Funding/support
    This editorial received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
     
    References
    1. World Health Organization. Considerations for COVID-19 surveillance for vulnerable populations. Manila: World Health Organization; 2021.
    2. World Health Organization. COVID-19 and the social determinants of health and health equity: evidence brief. Geneva: World Health Organization; 2021.
    3. Irwin M, Lazarevic B, Soled D, Adesman A. The COVID-19 pandemic and its potential enduring impact on children. Curr Opin Pediatr 2022;34:107-15. Crossref
    4. Wurm J, Ritz N, Zimmermann P. COVID-19 in children: evolving epidemiology, immunology, symptoms, diagnostics, treatment, post covid conditions, prevention strategies, and future directions. J Allergy Clin Immunol 2024 Nov 15. Epub ahead of print. Crossref
    5. Leung KK, Ku SW, Fung RC, et al. Airway management in children with COVID-19. Hong Kong Med J 2022;28:315-20. Crossref
    6. Wong JS, Wong TS, Chua GT, et al. COVID toe in an adolescent boy: a case report. Hong Kong Med J 2022;28:175-7. Crossref
    7. Chua GT, Wong JS, Chung J, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2: a case report. Hong Kong Med J 2022;28:76-8. Crossref
    8. Chow CM, Cheong PK, Hu J, Ching JY. Can a microbiota-derived health supplement mitigate adverse events after COVID-19 vaccination in children? Hong Kong Med J 2023;29:542-4. Crossref
    9. Leung KK, Hon KL, Ip P, Ng DK. COVID-19 and children: potential impacts and alleviation strategies. Hong Kong Med J 2023;29:443-7. Crossref
    10. Golden AR, Srisarajivakul EN, Hasselle AJ, Pfund RA, Knox J. What was a gap is now a chasm: remote schooling, the digital divide, and educational inequities resulting from the COVID-19 pandemic. Curr Opin Psychol 2023;52:101632.Crossref
    11. Ding Y, Guan H, Du K, Zhang Y, Wang Z, Shi Y. Asthenopia prevalence and vision impairment severity among students attending online classes in low-income areas of western China during the COVID-19 pandemic. Hong Kong Med J 2023;29:150-7. Crossref
    12. Nana M, Hodson K, Lucas N, Camporota L, Knight M, Nelson-Piercy C. Diagnosis and management of COVID-19 in pregnancy. BMJ 2022;377:e069739. Crossref
    13. Ahmed AK, Sijercic VC, Sayad R, et al. Risks and preventions for pregnant women and their preterm infants in a world with COVID-19: a narrative review. Vaccines (Basel) 2023;11:640. Crossref
    14. Leung HH, Kwok CY, Sahota DS, et al. Effects of strict public health measures on seroprevalence of anti- SARS-CoV-2 antibodies during pregnancy. Hong Kong Med J 2022;28:294-9. Crossref
    15. Lok WY, Chow CY, Kong CW, To WW. Knowledge, attitudes, and behaviours of pregnant women towards COVID-19: a cross-sectional survey. Hong Kong Med J 2022;28:124-32. Crossref
    16. Hui PW, Seto MT, Cheung KW. Behavioural adaptations and responses to obstetric care among pregnant women during an early stage of the COVID-19 pandemic in Hong Kong: a cross-sectional survey. Hong Kong Med J 2022;28:367-75. Crossref
    17. Tam EM, Kwan YK, Ng YY, Yam PW. Clinical course and mortality in older patients with COVID-19: a clusterbased study in Hong Kong. Hong Kong Med J 2022;28:215-22. Crossref
    18. Shea YF, Ip WC, Luk JK. Comparison of the pattern of elderly abuse in Hong Kong before and after the COVID-19 pandemic. Hong Kong Med J 2022;28:502-3. Crossref
    19. Gardner W, States D, Bagley N. The coronavirus and the risks to the elderly in long-term care. J Aging Soc Policy 2020;32:310-5. Crossref
    20. Czerniewska A, Sharkey A, Portela A, Drapkin S, Mustafa S. National COVID-19 preparedness and response plans: a global review from the perspective of services for maternal, newborn, child and adolescent health and older people. BMJ Glob Health 2024;9:e013711. Crossref

    Enhancing human papillomavirus vaccine acceptance in Hong Kong: a call for action and public education

    © Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
     
    EDITORIAL
    Enhancing human papillomavirus vaccine acceptance in Hong Kong: a call for action and public education
    Zigui Chen, BS, PhD1; Jason YK Chan, FRCSEd (ORL), FHKAM (Otorhinolaryngology)2; Paul KS Chan, FHKCPath, FHKAM (Pathology)1
    1 Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    2 Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
     
    Corresponding author: Dr Zigui Chen (zigui.chen@cuhk.edu.hk)
     
     Full paper in PDF
     
    Growing global awareness of human papillomavirus (HPV) and its associated health risks, particularly cervical cancer, has led to widespread implementation of HPV vaccination programmes. In Hong Kong, HPV remains a substantial but underestimated public health burden, as Chu et al1 highlighted in their recent study published in the Hong Kong Medical Journal. The study investigated parental acceptance of HPV vaccination for boys and girls in Primary 4 to 6, offering critical insights into the factors influencing vaccination uptake.
     
    Human papillomavirus vaccine awareness and uptake
    The study by Chu et al1 evaluated parental awareness, knowledge, and attitudes towards HPV vaccination in Hong Kong, a city that—like many others—has integrated HPV vaccination into its Childhood Immunisation Programme (HKCIP). As these vaccination programmes expand globally, an understanding of factors that influence parental decision-making is needed to improve uptake and reduce the burden of HPV-associated diseases. Chu et al1 found high awareness of HPV among most parents (81.4% among boys’ parents and 78.5% among girls’ parents). Despite this awareness, knowledge about HPV and the vaccine remains limited. Moreover, the actual vaccine uptake rates are alarmingly low: 6.8% for boys and 4.9% for girls.1 The study identified several key factors influencing vaccine acceptance, including parental HPV vaccination status, household income, and concerns about HPV infection.1 Focused efforts regarding safety education and implement catch-up vaccination are needed to overcome vaccine hesitancy in Hong Kong.
     
    These results are consistent with global tendencies towards vaccine hesitancy and low uptake, despite the documented effectiveness of HPV vaccines in preventing HPV-related diseases. For example, a study by Wang et al2 in China similarly showed that parental knowledge of HPV was limited, and acceptance was hindered by misconceptions about the vaccine’s safety and necessity, particularly for boys. In the United States, although HPV vaccination coverage has increased since introduction of the vaccine, disparities remain. A 2021 study revealed that only 58.6% of adolescents were fully vaccinated; the acceptance rate was lower among boys than among girls.3 In Europe, similar trends have been observed. Countries such as Italy have reported relatively low HPV vaccination rates due to scepticism about vaccine safety and insufficient public health campaigns.4
     
    These regional disparities in vaccine uptake suggest that although awareness campaigns may increase recognition of HPV, they often do not result in higher vaccination rates unless they address underlying concerns about vaccine safety, efficacy, and the perceived importance of vaccinating boys. The study by Chu et al1 showed results consistent with this challenge in Hong Kong, where boys’ parents were significantly less likely to accept the vaccine than girls’ parents, despite the government’s efforts to provide the vaccine free of charge to girls under the HKCIP.
     
    Barriers to human papillomavirus vaccine acceptance
    A key finding in the study by Chu et al1 is the misconception about the cost of the vaccine. Although the HPV vaccine is provided free of charge to girls under the HKCIP, many parents still considered it too expensive. This finding indicates a disconnect between the availability of free vaccines and public understanding of the Programme, likely exacerbated by the coronavirus disease 2019 pandemic, which disrupted routine healthcare services and public health campaigns worldwide.5
     
    The reluctance of boys’ parents to accept the HPV vaccine also reflects global trends. Many parents continue to primarily associate HPV with cervical cancer, which is regarded as a disease that only affects girls and women. This association has persisted despite increasing evidence that links HPV to other cancers, such as penile, anal, and oropharyngeal cancers, which affect boys and men.6 7 This perception gap is not unique to Hong Kong; studies from the Australia, Georgia, and the United States have also identified gender bias as a major barrier to HPV vaccine acceptance for boys.8 9 10
     
    Moreover, the study by Chu et al1 demonstrated that boys’ parents were more likely than girls’ parents to discuss sexually transmitted diseases with their children (33% vs 15.2%). Despite these discussions, vaccine acceptance remained lower for boys. This paradox suggests that although parents may be aware of the risks of HPV transmission, they may not fully understand the broader health implications of the virus for both genders or the protective benefits of vaccination.
     
    The importance of public education and policy interventions
    The study by Chu et al1 underscores the urgent need for more effective public education campaigns in Hong Kong. Public health authorities should focus on dispelling misconceptions about the cost and safety of the HPV vaccine, along with their efforts to emphasise its importance for both boys and girls. The fact that many parents remain unaware of the free vaccination programme for girls indicates a lack of effective communication between the government and the public. This communication issue is not unique to Hong Kong; similar challenges have been reported in Europe, where vaccine uptake has been hindered by misinformation and inadequate public health messaging.11
     
    Additionally, targeted interventions should be implemented to address the gender disparity in vaccine acceptance. Public health campaigns must highlight the risks of HPV-related cancers for boys and the benefits of achieving high vaccination coverage in both genders. Studies have shown that gender-neutral vaccination programmes, such as those implemented in Australia12 and some parts of Europe,12 13 have led to significant reductions in HPV infections and associated diseases. These programmes also provide indirect protection for unvaccinated individuals through herd immunity, reinforcing the importance of including boys in national vaccination strategies.14 15
     
    Recommendations for future research and policy
    To improve HPV vaccination rates in Hong Kong and worldwide, policymakers and healthcare providers should consider the following recommendations:
    1. Expand public health campaigns: Government-led campaigns should focus on increasing awareness regarding the availability of free vaccines for girls and the benefits of vaccinating boys. These campaigns must address common misconceptions about HPV and concerns about the vaccine’s cost, safety, and efficacy.
    2. Enhance school-based vaccination programmes: Schools serve as a critical platform for vaccine delivery and education. The integration of HPV education into the school curriculum, along with routine vaccination programmes, could help increase acceptance among both parents and students.
    3. Implement gender-neutral vaccination policies: Given the evidence supporting gender-neutral vaccination programmes, policymakers should consider expanding free HPV vaccination to boys under the HKCIP. This would protect boys from HPV-related diseases while contributing to the overall reduction of HPV transmission within the community.
    4. Address vaccine hesitancy through healthcare providers: Physicians and other healthcare professionals play a pivotal role in promoting vaccination. Efforts to train healthcare providers to effectively communicate the benefits of the HPV vaccine and address parental concerns are essential for greater vaccine uptake.
     
    Conclusion
    The study by Chu et al1 provides valuable insights into the factors influencing HPV vaccine acceptance among parents in Hong Kong. The low uptake rates, despite high awareness, highlight the need for more robust public health campaigns and gender-neutral vaccination policies. By addressing misconceptions about the vaccine and expanding access to boys, Hong Kong can improve its vaccination coverage and protect future generations from HPV-related diseases. Similar efforts in other regions have shown that, with the right interventions, substantial progress can be made in increasing HPV vaccine acceptance and uptake.
     
    Author contributions
    All authors have contributed equally to the concept, development and critical revision of the manuscript. All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
     
    References
    1. Chu JK, Sing CW, Li Y, Wong PH, So EY, Wong IC. Factors affecting human papillomavirus vaccine acceptance among parents of Primary 4 to 6 boys and girls in Hong Kong. Hong Kong Med J 2024;30:386-99. Crossref
    2. Wang Z, Wang J, Fang Y, et al. Parental acceptability of HPV vaccination for boys and girls aged 9-13 years in China—a population-based study. Vaccine 2018;36:2657-65. Crossref
    3. Pingali C, Yankey D, Elam-Evans LD, et al. National, regional, state, and selected local area vaccination coverage among adolescents aged 13-17 years—United States, 2020. MMWR Morb Mortal Wkly Rep 2021;70:1183-90. Crossref
    4. Montalti M, Salussolia A, Capodici A, et al. Human papillomavirus (HPV) vaccine coverage and confidence in Italy: a nationwide cross-sectional study, the OBVIOUS project. Vaccines (Basel) 2024;12:187. Crossref
    5. Shet A, Carr K, Danovaro-Holliday MC, et al. Impact of the SARS-CoV-2 pandemic on routine immunisation services: evidence of disruption and recovery from 170 countries and territories. Lancet Glob Health 2022;10:e186-94. Crossref
    6. Machalek DA, Poynten M, Jin F, et al. Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol 2012;13:487-500. Crossref
    7. Gillison ML, Chaturvedi AK, Anderson WF, Fakhry C. Epidemiology of human papillomavirus–positive head and neck squamous cell carcinoma. J Clin Oncol 2015;33:3235-42. Crossref
    8. Gilkey MB, Calo WA, Moss JL, Shah PD, Marciniak MW, Brewer NT. Provider communication and HPV vaccination: the impact of recommendation quality. Vaccine 2016;34:1187-92. Crossref
    9. Petagna CN, Perez S, Hsu E, et al. Facilitators and barriers of HPV vaccination: a qualitative study in rural Georgia. BMC Cancer 2024;24:592. Crossref
    10. Netfa F, King C, Davies C, et al. Perceived facilitators and barriers to the uptake of the human papillomavirus (HPV) vaccine among adolescents of Arabic-speaking mothers in NSW, Australia: a qualitative study. Vaccine X 2023;14:100335. Crossref
    11. Karafillakis E, Simas C, Jarrett C, et al. HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe. Hum Vaccin Immunother 2019;15:1615-27. Crossref
    12. Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. Lancet 2019;394:497-509.Crossref
    13. Diakite I, Nguyen S, Sabale U, et al. Public health impact and cost-effectiveness of switching from bivalent to nonavalent vaccine for human papillomavirus in Norway: incorporating the full health impact of all HPV-related diseases. J Med Econ 2023;26:1085-98. Crossref
    14. Brisson M, Bénard É, Drolet M, et al. Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models. Lancet Public Health 2016;1:e8-17. Crossref
    15. Brisson M, Kim JJ, Canfell K, et al. Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries. Lancet 2020;395:575-90. Crossref

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