Use of hair analysis in the diagnosis of heavy metal poisoning: report of three cases

ABSTRACT

Hong Kong Med J 2004;10:197-200 | Number 3, June 2004
MEDICAL PRACTICE
Use of hair analysis in the diagnosis of heavy metal poisoning: report of three cases
WT Poon, SC Ling, AYW Chan, TWL Mak
Department of Pathology, Princess Margaret Hospital, 2-10 Princess Margaret Hospital Road, Laichikok, Hong Kong
 
 
We report three paediatric cases of suspected heavy metal poisoning that presented with non-specific symptoms. Hair samples of the three patients were sent overseas for analysis; results showed abnormal levels of many elements, including some heavy metals. A diagnosis of heavy metal poisoning was made and chelation therapy was offered to each patient. Blood levels for some heavy metals were subsequently checked and all were within the normal range. The original diagnosis of heavy metal poisoning was therefore not substantiated. The patients did not have a history of exposure to heavy metals or specific clinical features of heavy metal poisoning. The non-invasive nature of hair analysis is tempting, but the validity of such testing in diagnosing heavy metal poisoning is questionable.
 
Key words: Hair/chemistry; Metals, heavy; Metals, heavy; Reproducibility of results
 
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Consensus statement on ischaemic stroke care in Hong Kong

ABSTRACT

Hong Kong Med J 2004;10:124-9 | Number 2, April 2004
MEDICAL PRACTICE
Consensus statement on ischaemic stroke care in Hong Kong
PW Ng, CY Huang, RTF Cheung, KS Wong, CK Wong, JMK Lam
Department of Medicine, United Christian Hospital, Kwun Tong, Hong Kong
 
 
OBJECTIVE. To issue guidelines for the care of acute stroke in Hong Kong, with the target audience of all health care professionals who are involved in acute stroke care.
 
PARTICIPANTS. The Hong Kong Neurological Society and the Hong Kong Stroke Society.
 
EVIDENCE. The panel applied the 'rule of evidence' used by the United States Agency for Health Care Policy and Research. When there is insufficient evidence, the recommendation was based on customary practice and was circulated among the members and fellows of the two societies before coming to a consensus.
 
CONSENSUS PROCESS. Group meetings were held in 2002 to review the literature about acute care for patients with ischaemic stroke and to issue a consensus statement with reference to the local health care system. Participants of the meetings were appointed by the councils of The Hong Kong Neurological Society and the Hong Kong Stroke Society. The draft statement was circulated among the members and fellows of the two societies for comments before it was finalised.
 
CONCLUSIONS. Ischaemic stroke is a heavy health care burden to Hong Kong. The current consensus statement provides a framework to establish a multidisciplinary approach towards its acute management.
 
Key words: Brain ischemia; Cerebrovascular accident; Hong Kong; Platelet aggregation inhibitors
 
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Management of extremity soft tissue sarcoma after unplanned incomplete resection: experience of a regional musculoskeletal tumour centre

ABSTRACT

Hong Kong Med J 2004;10:117-22 | Number 2, April 2004
MEDICAL PRACTICE
Management of extremity soft tissue sarcoma after unplanned incomplete resection: experience of a regional musculoskeletal tumour centre
CK Wong, YL Lam, YC So, KC Ngan, KY Wong
Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong
 
 
This study reviews the presentation and management of extremity soft tissue sarcoma after unplanned incomplete resection in a musculoskeletal tumour centre in Hong Kong. Medical records of 18 patients who were referred to our centre for further management from January 1995 to May 2001 after inadequate tumour excision were reviewed. Fourteen patients had been referred from private clinics and four from public hospitals. At initial presentation, 10 patients had lesions exceeding 5 cm, nine had a tumour deep in the subfascial plane, and eight had tumours that had recently increased in size. Sixteen had no preoperative radiological assessment or biopsy performed before excision. All except two patients needed additional skin and muscle reconstruction in a subsequent re-resection, and 12 required postoperative radiotherapy. Two patients subsequently developed distant metastases, and one patient died of an unrelated cause. No amputations were required, and no major complications arose from second surgery. Physicians' alertness towards the possible malignancy of soft tissue masses in extremities is important to avoid a potentially mutilating second resection. Well-planned re-resection in a specialised tumour centre can achieve satisfactory local control of disease.
 
Key words: Neoplasm, residual; Sarcoma
 
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Consensus statement on iodine deficiency disorders in Hong Kong

ABSTRACT

Hong Kong Med J 2003;9:446-53 | Number 6, December 2003
MEDICAL PRACTICE
Consensus statement on iodine deficiency disorders in Hong Kong
Expert Panel Group on Iodine Deficiency Disorders in Hong Kong
 
 
This article reviews the available data on the study of iodine deficiency disorders in Hong Kong and to discuss the approach towards preventingsuch disorders in Hong Kong. The importance of iodine and iodine deficiency disorders is described, and the available data on the dietary iodine intake and urinary iodine concentration in different populations of Hong Kong are summarised and discussed. Dietary iodine insufficiency among pregnant women in Hong Kong is associated with maternal goitrogenesis and hypothyroxinaemia as well as neonatal hypothyroidism. Borderline iodine deficiency exists in the expectant mothers in Hong Kong. Women of reproductive age, and pregnant and lactating women should be made aware and educated to have an adequate iodine intake, such as iodised salt, as an interim measure. A steering group involving all stakeholders should be formed to advise on the strategy of ensuring adequate iodine intake, including universal iodisation of salt in Hong Kong. Continuous surveillance of iodine status in the Hong Kong population is necessary.
 
Key words: Deficiency disease; Iodine
 
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Magnetic resonance imaging in ischaemic heart disease

ABSTRACT

Hong Kong Med J 2003;9:370-6 | Number 5, October 2003
MEDICAL PRACTICE
Magnetic resonance imaging in ischaemic heart disease
WWM Lam, NMS So, A Chan, JE Sanderson, C Metreweli
Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
Magnetic resonance imaging has an increasing role in the assessment of ischaemic heart disease. Its superb spatial and temporal resolution currently allows accurate assessment of cardiac function, regional wall motion, and the extent of myocardial infarction. Regional myocardial perfusion can also be assessed, most commonly by a first-pass technique. Non-invasive imaging of the coronary arteries by various magnetic resonance imaging techniques represents a major advance in recent years. In the foreseeable future, magnetic resonance imaging may become a single, comprehensive examination for the assessment of ischaemic heart disease.
 
Key words: Magnetic resonance imaging; Myocardial ischemia
 
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Thrombotic thrombocytopenic purpura as a rare complication in childhood systemic lupus erythematosus: case report and literature review

ABSTRACT

Hong Kong Med J 2003;9:363-8 | Number 5, October 2003
MEDICAL PRACTICE
Thrombotic thrombocytopenic purpura as a rare complication in childhood systemic lupus erythematosus: case report and literature review
WK Chak, DSY Lam, WH Lo, CM Hui, SN Wong
Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, Hong Kong
 
 
Thrombotic thrombocytopenic purpura is a rare but serious condition in childhood. It can be idiopathic or a complication of other diseases or drug therapy. We report on a 12-year-old Chinese girl who presented with fulminant systemic lupus erythematosus with progressive renal failure, pancytopenia, and cerebral dysfunction due to thrombotic thrombocytopenic purpura. The patient also had Pneumocystis carinii pneumonia, Pseudomonas septicaemia, and Herpes zoster infections as a result of immunosuppressive treatment. She responded to combined therapy with pulse methylprednisolone, cyclophosphamide, plasmapheresis, and intensive care support, and completely recovered renal and neurological function. A review of the English-language medical literature since 1968 identified 20 other paediatric cases of systemic lupus erythematosus and thrombotic thrombocytopenic purpura. Clinical features, treatment, and outcome of these cases are presented and discussed. Early recognition is important, and although plasmapheresis is not of proven benefit in severe cases of systemic lupus erythematosus, it is life-saving in lupus-related thrombotic thrombocytopenic purpura and must be instituted early to avoid a poor outcome.
 
Key words: Lupus erythematosus, systemic; Plasmapheresis; Purpura, thrombotic thrombocytopenic
 
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A practical guide to capacity assessment and patient consent in Hong Kong

ABSTRACT

Hong Kong Med J 2003;9:284-9 | Number 4, August 2003
MEDICAL PRACTICE
A practical guide to capacity assessment and patient consent in Hong Kong
JG Wong, P Scully
Department of Psychiatry, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
 
 
A person’s decision-making capacity is pivotal when a doctor determines whether a person has the ability to make his or her own decisions, and thus it has major clinical, ethical, and legal significance, especially in Hong Kong, where the Mental Health Ordinance has introduced Guardianship provisions and provisions for the treatment of mentally incapacitated persons. This paper examines the legal concept of decision-making capacity and its clinical assessment within the local context. It is important for doctors to be aware of the legal mechanisms under which both urgent and non-urgent treatment can be given to mentally incapacitated persons, provided that the treatment is necessary and given in the best interests of the patient.
 
Key words: Decision making; Informed consent; Mental competency
 
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Subfascial endoscopic perforator surgery for venous ulcers

ABSTRACT

Hong Kong Med J 2003;9:279-82 | Number 4, August 2003
MEDICAL PRACTICE
Subfascial endoscopic perforator surgery for venous ulcers
DWH Lee, YH Lam, ACW Chan, SCS Chung
Department of Surgery, North District Hospital, 9 Po Kin Road, Hong Kong
 
 
We report the treatment and outcomes of 12 patients who underwent subfascial endoscopic perforator surgery for severe chronic venous insufficiency and venous ulceration. All patients had received prior superficial venous ablative surgery and presented with incompetent perforating veins in the calf and persistent venous ulceration (lasting >10 years). Outcome measures included ulcer healing time, recurrence, clinical symptom, and disability scores. There was one wound complication after subfascial endoscopic perforator surgery. The cumulative ulcer healing rate was 25% at 3 months, 42% at 6 months, and 92% at 1 year. One patient developed ulcer recurrence at 12 months after surgery. The mean clinical score and disability score decreased from 13.00 (standard deviation, 2.26) to 4.83 (1.47) and 1.75 (0.45) to 0.50 (0.52), respectively (P<0.001) after a median follow-up of 15.0 months (interquartile range, 12.0-21.5 months). Subfascial endoscopic perforator surgery was safe and effective in the treatment of patients with severe chronic venous insufficiency and venous ulceration caused by incompetent perforating veins in the calf.
 
Key words: Endoscopy; Recurrence; Treatment outcome; Varicose ulcer; Venous insufficiency
 
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The application of a multisensory Snoezelen room for people with learning disabilities—Hong Kong experience

ABSTRACT

Hong Kong Med J 2003;9:122-6 | Number 2, April 2003
MEDICAL PRACTICE
The application of a multisensory Snoezelen room for people with learning disabilities—Hong Kong experience
HWM Kwok, YF To, HF Sung
Psychiatric Unit for Learning Disabilities, Kwai Chung Hospital, 3-15 Kwai Chung Hospital Road, Hong Kong
 
 
In recent years there has been a considerable increase in the use of complementary therapies in the field of learning disabilities. This paper describes the use of a Snoezelen (multisensory) room for adults with learning disabilities in a psychiatric setting in Hong Kong. Theoretical and operational issues are discussed. The demographic and clinical data of a cohort of 96 patients who had used the room were reviewed. Rating forms were completed by their carers or staff at the end of the course to provide a subjective evaluation of the effectiveness of treatment. This is followed by three case reports. In view of the rising popularity of the multisensory room for people with learning disabilities, more research of the impact and therapeutic values is recommended.
 
Key words: Complementary therapies; Hong Kong; Mental retardation
 
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Macroprolactin—a cause of pseudohyperprolactinaemia

ABSTRACT

Hong Kong Med J 2003;9:119-21 | Number 2, April 2003
MEDICAL PRACTICE
Macroprolactin—a cause of pseudohyperprolactinaemia
YP Yuen, JPS Lai, KM Au, AYW Chan, TWL Mak
Department of Pathology, Princess Margaret Hospital, Laichikok, Hong Kong
 
 
Macroprolactin is a complex of immunoglobulin G and monomeric prolactin with little biological activity in vivo. Macroprolactin cross-reacts in modern commercial prolactin assays, however, leading to pseudohyperprolactinaemia. This report is of three patients with macroprolactinaemia and the untoward consequences if this benign condition is misdiagnosed as genuine hyperprolactinaemia are discussed. One adult and one child without symptoms of hyperprolactinaemia were incidentally found to have elevated serum prolactin levels, one of whom had a pituitary incidentaloma. Repeat prolactin measurement after polyethylene glycol precipitation showed that the majority of circulating prolactin was macroprolactin. The third patient had galactorrhoea and pituitary microadenoma. Polyethylene glycol study showed that macroprolactinaemia exists simultaneously with genuine hyperprolactinaemia leading to falsely high serum prolactin levels. The recognition of this relatively common and benign condition is important in order to avoid misdiagnosis and unnecessary investigations and treatment. Particular attention must be paid to patients in whom the clinical and radiological findings are incompatible.
 
Key words: Hyperprolactinemia; Immunoassay; Polyethylene glycol; Prolactin
 
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