A rare cutaneous fungal infection complicating bacterial necrotising fasciitis

ABSTRACT

Hong Kong Med J 2008;14:314-6 | Number 4, August 2008
CASE REPORT
A rare cutaneous fungal infection complicating bacterial necrotising fasciitis
CK Chen, SH Wan, SK Kou
Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
We report a case of bacterial necrotising fasciitis complicated by the rare fungus Absidia corymbifera. Although this fungal infection is rare, the prognosis is poor and it therefore requires attention. Only 30 cases have been reported since 1874, and we are the first group to report this clinical scenario in our locality. Using a comprehensive journal review, we discuss the expected clinical course and optimal management.
 
Key words: Absidia; Fasciitis, necrotizing; Mucormycosis
 
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Primitive neuroectodermal tumour of the kidney: radiologic-pathological correlations

ABSTRACT

Hong Kong Med J 2008;14:240-3 | Number 3, June 2008
CASE REPORT
Primitive neuroectodermal tumour of the kidney: radiologic-pathological correlations
YW Chea, Rashi Agrawal, Angeline CC Poh
Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608
 
 
A primitive neuroectodermal tumour of the kidney is a rare malignancy. We report the computed tomographic features and the histopathological correlation of such a tumour occurring in a middle-aged man. Although the radiological appearance has significant overlap with other renal tumours, this tumour should be included in the differential diagnosis of a large renal mass in younger patients.
 
Key words: Kidney neoplasms; Neuroectodermal tumors, primitive, peripheral; Tomography, X-ray computed
 
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Multimodal computed tomography evaluation before thrombolysis in acute ischaemic stroke

ABSTRACT

Hong Kong Med J 2008;14:236-9 | Number 3, June 2008
CASE REPORT
Multimodal computed tomography evaluation before thrombolysis in acute ischaemic stroke
Thomas W Leung, Wynnie WM Lam, Simon CH Yu, Cecilia SF Leung, Yannie OY Soo, Lawrence KS Wong
Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
Currently, when stroke patients are offered thrombolytic therapy, their ischaemic stroke subtypes are usually unknown. Given the risk of haemorrhage that accompanies thrombolytic therapy, unselective (or undiscriminating) use of recombinant tissue plasminogen activator in patients without large-artery thromboemboli is potentially hazardous. Advances in computed tomography techniques have enabled the stroke pathophysiology to be quickly delineated by multimodal computed tomography without compromise in time for recombinant tissue plasminogen activator administration. Through description of the investigation of a typical stroke patient, we report how this technique is feasible in a regional hospital and may guide judicious use of recombinant tissue plasminogen activator.
 
Key words: Cerebral hemorrhage; Thrombolytic therapy; Tissue plasminogen activator; Tomography, X-ray computed
 
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Acute myocardial infarction found by multi-detector computed tomography ordered for suspected aortic dissection

ABSTRACT

Hong Kong Med J 2008;14:233-5 | Number 3, June 2008
CASE REPORT
Acute myocardial infarction found by multi-detector computed tomography ordered for suspected aortic dissection
Sherwin SW Lo, WK Kwok
Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
Urgent requests for contrast computed tomographic scans of the thorax are often performed for suspected aortic dissections and pulmonary embolisms, both of which have clinical features similar to those seen in acute myocardial infarction. We present two cases with computed tomographic scans showing decreased myocardial enhancement, suggestive of acute myocardial infarction, but no evidence of aortic dissection. Acute myocardial infarction was subsequently confirmed by coronary angiography.
 
Key words: Coronary angiography; Myocardial infarction; Tomography, X-ray computed
 
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Use of magnetic resonance imaging for detecting clinically and mammographically occult ductal carcinoma in situ

ABSTRACT

Hong Kong Med J 2008;14:229-32 | Number 3, June 2008
CASE REPORT
Use of magnetic resonance imaging for detecting clinically and mammographically occult ductal carcinoma in situ
Gladys Lo, Polly SY Cheung
Department of Diagnostic and Interventional Radiology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong
 
 
We report on two cases where breast magnetic resonance imaging examination changed clinical management. Breast magnetic resonance imaging is now recognised as an indispensable adjunctive examination to mammography and ultrasound. In each of the two cases described, breast magnetic resonance imaging revealed unsuspected, extensive, and mammographically and ultrasonologically occult, ductal carcinoma in situ. In each of these cases, planned breast conserving surgery was changed to mastectomy. The success of breast conservation treatment depends on removal of all tumour with clear margins at the time of surgery. Magnetic resonance imaging is now considered the most sensitive method for evaluating the extent of breast cancer. Breast magnetic resonance imaging has a very high sensitivity for invasive carcinoma (near 100%), and recent studies show its specificity in high-risk patients is between 93 and 99%. Magnetic resonance imaging may well be proven an important adjunctive examination in patients who have dense breasts or extensive fibrocystic change.
 
Key words: Breast neoplasms; Carcinoma, ductal, breast; Magnetic resonance imaging; Mammography
 
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A novel CASR gene mutation in an octogenarian with asymptomatic hypercalcaemia

ABSTRACT

Hong Kong Med J 2008;14:226-8 | Number 3, June 2008
CASE REPORT
A novel CASR gene mutation in an octogenarian with asymptomatic hypercalcaemia
Ronald CW Ma, CW Lam, WY So, Peter CY Tong, Clive S Cockram, CC Chow
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
An increasing number of patients are diagnosed with primary hyperparathyroidism after having hypercalcaemia detected incidentally during routine biochemical screening. Many are asymptomatic at the time of diagnosis. An 80-year-old woman was found to have asymptomatic hypercalcaemia. Initial investigations suggested a diagnosis of primary hyperparathyroidism. Subsequent investigations revealed that, in fact, she had familial hypocalciuric hypercalcaemia. Direct DNA sequencing of the calcium-sensing receptor (CASR) gene confirmed that the patient was heterozygous for c.2501delC, a novel frame shift mutation predicted to cause loss of function of the CASR gene. Several other family members were subsequently found to carry the same mutation. Suspected cases of hypocalciuric hypercalcaemia should be confirmed by detection of mutations within the CASR gene. Establishing the correct diagnosis will enable the patient and family members to avoid unnecessary investigations or operations.
 
Key words: Hypercalcemia; Hyperparathyroidism; Receptors, calcium-sensing
 
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Arteriovenous malformation related to the pinna

ABSTRACT

Hong Kong Med J 2008;14:157-9 | Number 2, April 2008
CASE REPORT
Arteriovenous malformation related to the pinna
Ravi Meher, Saurabh Varshney, HC Pant
Department of ENT & Head and Neck Surgery, Lok Nayak Hospital and Associated Maulana Azad Medical College, New Delhi, India
 
 
Arteriovenous malformations are rare in the head and neck region and generally arise from intracranial vessels. We present two rare cases with spontaneous arteriovenous malformations related to the ear. The role of magnetic resonance imaging and colour Doppler sonography in the diagnosis and management of such cases is discussed along with a review of the literature.
 
Key words: Arteriovenous malformations; Ear; Magnetic resonance imaging; Ultrasonography, Doppler, color
 
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Brodie's abscess of the ulna caused by Salmonella typhi

ABSTRACT

Hong Kong Med J 2008;14:154-6 | Number 2, April 2008
CASE REPORT
Brodie's abscess of the ulna caused by Salmonella typhi
KC Ip, YL Lam, Robert YP Chang
Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Kowloon, Hong Kong
 
 
Osteomyelitis caused by Salmonella typhi is rare in patients with no haemoglobinopathies or other diseases causing immunosuppression. Brodie's abscess is a special variety of subacute or chronic osteomyelitis. An otherwise healthy woman who presented with forearm swelling for 6 months was diagnosed with a Brodie?s abscess of the ulna caused by Salmonella typhi. Magnetic resonance imaging and a computed tomography–guided needle biopsy were performed. She was later found to be a Salmonella carrier. The Brodie's abscess was treated by surgical debridement and a course of antibiotics. The clinical, radiological, and management aspects of the disease are discussed.
 
Key words: Abscess; Osteomyelitis; Salmonella typhi
 
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Caecal metastasis from a primary small-cell lung carcinoma

ABSTRACT

Hong Kong Med J 2008;14:152-3 | Number 2, April 2008
CASE REPORT
Caecal metastasis from a primary small-cell lung carcinoma
CP Lau, WK Leung
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
Small bowel metastases from a primary lung carcinoma are rare. We report a case of a 59-year-old male with a primary small-cell lung carcinoma who developed anaemia and bowel symptoms. On colonoscopic examination he was found to have a tumour in the caecum near the ileocaecal valve, which was biopsied, revealing small neuroendocrine tumour cells. The patient then underwent systemic chemotherapy, which achieved a reduction in the size of the primary lung tumour and an improvement in his bowel symptoms. It is important that such a rare condition be recognised early as complicated intestinal metastases from a lung carcinoma can lead to high mortality rates and poor short-term outcome. With advances in chemotherapy and palliative care, patients with metastatic lung carcinoma can sometimes survive more than a year with reasonable quality of life.
 
Key words: Carcinoma, small cell; Intestinal neoplasms; Lung metastasis; Neoplasm metastasis
 
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Umbilical cord ulceration causing foetal haemorrhage and stillbirth

ABSTRACT

Hong Kong Med J 2008;14:148-51 | Number 2, April 2008
CASE REPORT
Umbilical cord ulceration causing foetal haemorrhage and stillbirth
Symphorosa SC Chan, Amy PK Lau, KF To, TY Leung, TK Lau, TN Leung
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
We report a case of umbilical cord ulceration associated with obstruction of the duodeno-jejunal junction by a peritoneal band. Umbilical cord ulceration is a rare condition; a literature review identified a total of 17 cases only. In all cases, the ulceration was associated with congenital intestinal obstruction. Cord ulceration usually presents as sudden foetal deterioration due to foetal haemorrhage. This condition is associated with high perinatal mortality and morbidity. The causes of this condition are still unknown, and prenatal diagnosis is difficult. Awareness of the possible association between umbilical cord ulceration and intestinal obstruction, and of the need to deliver such pregnancies immediately when an abnormal foetal heart rate pattern develops might be the only means of preventing intrauterine death and improving neonatal outcomes.
 
Key words: Duodenal obstruction; Intestinal atresia; Ulcer; Umbilical cord
 
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