Benign metastasising leiomyoma after hysterectomy and bilateral salpingo-oophorectomy

ABSTRACT

Hong Kong Med J 2012;18:153-5 | Number 2, April 2012
CASE REPORT
Benign metastasising leiomyoma after hysterectomy and bilateral salpingo-oophorectomy
Manisha M Beck, Bivas Biswas, Aparajita D’Souza, Ramani Kumar
Christian Medical College and Hospital, Vellore, Tamil Nadu, India
 
 
Benign metastasising leiomyomatosis is a rare condition affecting women in the reproductive age-group with a history of uterine fibroids, who have undergone treatment by myomectomy or hysterectomy. It is characterised by development of multiple, indolent, smooth muscle tumours outside the uterus, most commonly in the lungs, and manifests several years after the uterine surgery. We describe the case of a young woman, who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy for multiple fibroids and a right ovarian cyst. After 5 years of being on oestrogen replacement therapy, she was detected to have benign metastasising leiomyoma, for which an additional laparotomy was performed. At laparotomy, removal of the pelvic mass was associated with several complications. The metastatic lesions in the lung responded well to progestogens (megestrol acetate) alone as evidenced by regression of the lesions detected at follow-up after 6 months and 1 year.
 
Key words: Leiomyomatosis; Lung Neoplasms; Megestrol acetate; Progestins
 
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Cough mixture abuse and rhabdomyolysis

ABSTRACT

Hong Kong Med J 2012;18:68-9 | Number 1, February 2012
CASE REPORT
Cough mixture abuse and rhabdomyolysis
Jenny SK Tsang, WY Au
Department of Psychiatry, Kwai Chung Hospital, 3-15 Kwai Chung Hospital Road, Hong Kong
 
 
Cough mixture abuse is an emerging problem among young men in Oriental countries. Its metabolic consequences have been recognised only recently. Such abusers can develop severe folate deficiency, which may be related to peripheral and central nervous system defects. We report three cough mixture abusers with rhabdomyolysis. All suffered from folate deficiencies and also had a history of anti-psychotic drug use. This represents one more life-threatening side-effect from cough mixture abuse.
 
Key words: Antitussive agents; Cough/drug therapy; Folic acid deficiency; Rhabdomyolysis; Substance-related disorders
 
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Giant urethral diverticulum calculus presenting as scrotal abscess

ABSTRACT

Hong Kong Med J 2012;18:66-7 | Number 1, February 2012
CASE REPORT
Giant urethral diverticulum calculus presenting as scrotal abscess
KW Chan, WH Chu, IC Law
Department of Surgery, Kwong Wah Hospital, Yaumatei, Hong Kong
 
 
We report herein a patient with a urethral calculus associated with urethral diverticulum. A 39-year-old man presented with scrotal swelling and acute retention of urine. Computed tomography of the pelvis and cystoscopy demonstrated a giant calculus in the proximal penile urethra. Emergency in-situ lithotripsy was performed. Complete stone clearance was achieved and a large urethral diverticulum was encountered. The rare occurrence of urethral diverticulum and associated stone disease were discussed.
 
Key words: Diverticulum; Scrotum; Urethral diseases; Urinary bladder neck obstruction; Urinary calculi
 
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Acute ischaemic stroke during short-term travel to high altitude

ABSTRACT

Hong Kong Med J 2012;18:63-5 | Number 1, February 2012
CASE REPORT
Acute ischaemic stroke during short-term travel to high altitude
T Chan, Winnie WY Wong, Jonathan KC Chan, Johnny KF Ma, Henry KF Mak
Department of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong
 
 
This is a case report of a young healthy adult who had acute cerebral infarcts after a short-term visit to high-altitude area. He developed acute onset of right-sided limb weakness and right hemianopia a few hours after arrival at an altitude of 3600 m by train. He was initially treated for high-altitude cerebral oedema but later computed tomography and magnetic resonance imaging confirmed ischaemic infarcts in the medial left occipital lobe and left thalamus. Subsequent investigations, including laboratory tests and imaging including an echocardiogram, revealed no culpable predisposing factors.
 
Key words: Altitude sickness; Brain edema; Cerebral infarction; Magnetic resonance imaging; Tomography, X-ray computed
 
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Neonatal herpes: what lessons to learn

ABSTRACT

Hong Kong Med J 2012;18:60-2 | Number 1, February 2012
CASE REPORT
Neonatal herpes: what lessons to learn
KL Hon, TF Leung, HM Cheung, Paul KS Chan
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
Vesicular rashes in neonates are challenging in terms of diagnosis and management. Herpes infection is an important diagnostic consideration. We report two illustrative neonatal cases of herpesvirus infections with vesicular rashes. Such babies may be remarkably asymptomatic. A high index of suspicion leading to a prompt diagnosis, timely quarantine measures, and institution of antiviral treatment are pivotal for desirable outcomes.
 
Key words: Herpes genitalis; Herpes simplex; Herpesvirus 2, human; Infant, newborns
 
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Genetic diagnosis of severe myoclonic epilepsy of infancy (Dravet syndrome) with SCN1A mutations in the Hong Kong Chinese patients

ABSTRACT

Hong Kong Med J 2011;17:500-2 | Number 6, December 2011
CASE REPORT
Genetic diagnosis of severe myoclonic epilepsy of infancy (Dravet syndrome) with SCN1A mutations in the Hong Kong Chinese patients
Chloe M Mak, KY Chan, Eric KC Yau, Sammy PL Chen, WK Siu, CY Law, CW Lam, Albert YW Chan
Kowloon West Cluster Laboratory Genetic Service, Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Laichikok, Hong Kong
 
 
Epilepsy is a clinically and genetically heterogeneous group of disorders. The advent of molecular genetics brings unprecedented advancement in diagnostic molecular pathology and reduces over-reliance on traditional clinical classification. Severe myoclonic epilepsy of infancy or Dravet syndrome is a catastrophic infantile-onset epilepsy. We report two unrelated Hong Kong Chinese patients with this condition presenting with febrile seizures, epilepsy with different semiologies, psychomotor retardation, and recurrent status epilepticus. Two different mutations were characterised, viz NM_001165963.1: c.680T>G; NP_001159435.1: p.I227S and NM_001165963.1: c.3953T>G; NP_001159435.1: p.L1318R (novel). Genetic characterisation conveys a definitive diagnosis and is important from the perspective of selecting anti-epileptic drug therapy and genetic counselling.
 
Key words: Epilepsies, myoclonic; DNA mutational analysis; Mutation; Nerve tissue proteins; Seizures, febrile
 
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Disseminated amyloidosis presenting with right proximal femur pathological fracture in a haemodialysis end-stage renal failure patient

ABSTRACT

Hong Kong Med J 2011;17:495-9 | Number 6, December 2011
CASE REPORT
Disseminated amyloidosis presenting with right proximal femur pathological fracture in a haemodialysis end-stage renal failure patient
Alexander PH Chan, Tom CY Cheung, SY Cheung, Eric PY Ho, Jason CH Fan, K Wang, KY Fung
Department of Orthopaedics and Traumatology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong
 
 
Osteoarticular amyloidosis can be one of the musculoskeletal system manifestations related to dialysis. We share our experience in dealing with a case of disseminated haemodialysis-associated amyloidosis in a 74-year-old end-stage renal failure patient. This patient suffered from a serious complication, namely an unprovoked pathological fracture at the basal neck region of the right femur. Polyarticular cystic and lytic lesions over the contralateral proximal femur, bilateral proximal humerus and the right lunate were noted on further imaging. In view of extensive amyloidotic infiltration into the proximal femur as well as the acetabulum, a cemented total hip arthroplasty operation was performed for pain relief and restoration of function. The radiological investigations, diagnostic challenges, operative as well as histopathological findings are discussed. This disease should be considered in the differential diagnosis of pathological juxta-articular fracture in patients undergoing haemodialysis.
 
Key words: Arthroplasty, replacement; Amyloidosis; Hip fractures; Kidney failure, chronic; Renal dialysis
 
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An unusual cause of retention of urine after intravesical Bacillus Calmette-Guérin therapy for superficial bladder cancer

ABSTRACT

Hong Kong Med J 2011;17:492-4 | Number 6, December 2011
CASE REPORT
An unusual cause of retention of urine after intravesical Bacillus Calmette-Guérin therapy for superficial bladder cancer
Jackie MK Cheung, Simon SM Hou, Sidney KH Yip, CF Ng
Division of Urology, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
We report an unusual complication of intravesical Bacillus Calmette-Guérin therapy for superficial bladder cancer, namely, retention of urine secondary to prostatic Bacillus Calmette-Guérin infection and abscess. A summary of the literature together with a review of its management is discussed.
 
Key words: Administration, intravesical; BCG vaccine; Prostatic diseases; Urinary bladder neoplasms
 
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Sacrococcygeal teratoma in adults: case report and literature review

ABSTRACT

Hong Kong Med J 2011;17:417-20 | Number 5, October 2011
CASE REPORT
Sacrococcygeal teratoma in adults: case report and literature review
Shiobhon Y Luk, YP Tsang, TS Chan, TF Lee, KC Leung
Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
Sacrococcygeal teratoma is one of the most common tumours in infants but rare in adults. We present a case of sacrococcygeal teratoma in a female adult. The clinical presentation, radiological and histological findings, management, and outcome are described.
 
Key words: Adenocarcinoma; Sacrococcygeal region; Teratoma
 
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Calcific tendinitis of the supraspinatus tendon in a 7-year-old boy: diagnostic challenges

ABSTRACT

Hong Kong Med J 2011;17:414-6 | Number 5, October 2011
CASE REPORT
Calcific tendinitis of the supraspinatus tendon in a 7-year-old boy: diagnostic challenges
CM Fong
Division of Paediatric Orthopaedics, Department of Orthopaedics and Traumatology, United Christian Hospital, Kwun Tong, Hong Kong
 
 
This report is of a case of acute calcific tendinitis of supraspinatus tendon in a 7-year-old boy who presented to the hospital with an acute painful shoulder after a fall. Initial radiographs mimicked fracture of the greater tuberosity of the humerus. Subsequent investigation confirmed that the appearance was due to a calcific tendinitis. The patient recovered shortly afterwards with complete resolution of the calcific lesion.
 
Key words: Calcinosis; Shoulder joint; Tendinopathy
 
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