Risk factors of long bone fracture in non-ambulatory cerebral palsy children

ABSTRACT

Hong Kong Med J 2006;12:426-31 | Number 6, December 2006
ORIGINAL ARTICLE
Risk factors of long bone fracture in non-ambulatory cerebral palsy children
CH Ko, PWT Tse, AKH Chan
Developmental Disabilities Unit, Department of Paediatrics and Adolescent Medicine, Caritas Medical Centre, 111 Wing Hong Street, Shamshuipo, Hong Kong
 
 
OBJECTIVES. To identify the risk factors for long bone fractures in non-ambulatory cerebral palsy children.
 
DESIGN. Case-control study.
 
SETTING. A residential rehabilitation centre in Hong Kong.
 
PATIENTS. The fracture group comprised 19 (13 male, 6 female) cerebral palsy children aged 4 years 5 months to 18 years 11 months (mean, 10 years; standard deviation, 3 years 9 months), who had their first long bone fracture during the period June 1992 to May 2001 inclusive. The control group was composed of 90 (46 male, 44 female) concomitant cerebral palsy residents aged 6 years 1 month to 16 years 11 months (mean, 9 years 11 months; standard deviation, 2 years 4 months) with no history of long bone fracture. Main outcome measures. Presence of features considered relevant to the risk of fracture, namely: anthropometry, feeding practice, orthopaedic surgery and duration of postoperative immobilisation, extremity contracture, anti-epileptic medications, and general health status in the 12 months prior to the fracture.
 
RESULTS. Of the 19 fracture episodes, 18 occurred in the femur and one in the tibia/fibula. Multivariate analysis revealed that weight for age Z scores (adjusted odds ratio=0.41, 95% confidence interval, 0.19-0.86) and recent postoperative immobilisation (weeks) [adjusted odds ratio=1.35, 95% confidence interval, 0.97-1.89] were independent predictors for fracture occurrence.
 
CONCLUSION. Early intervention targeting these risk factors may reduce the fracture risk in non-ambulatory cerebral palsy children.
 
Key words: Cerebral palsy; Fractures, bone; Immobilization
 
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A single-centre experience of 40 laparoscopic liver resections

ABSTRACT

Hong Kong Med J 2006;12:419-25 | Number 6, December 2006
ORIGINAL ARTICLE
A single-centre experience of 40 laparoscopic liver resections
CN Tang, KK Tsui, JPY Ha, GPY Yang, MKW Li
Department of Surgery, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong
 
 
OBJECTIVE. To review results of laparoscopic liver resections, particularly in those patients with hepatic malignancy and recurrent pyogenic cholangitis.
 
DESIGN. Retrospective analysis.
 
SETTING. Minimal access surgery training centre, Hong Kong.
 
PATIENTS. Patients with pathologies located at anterio-inferio-lateral segments (Couinaud segments 2, 3, 4b, 5, 6) for laparoscopic resection were recruited during the period 1998 to 2005. Patients were excluded from review if they had: pathologies at central locations and the superior and posterior segments (4a, 7, 8), large tumours (>5 cm in diameter), and those close to major vasculature or the liver hilum.
 
RESULTS. During the study period, we attempted 40 such laparoscopic liver resections, excluding marsupialisations and resections for simple liver cysts. There were 20 female and 20 male patients, with a mean age of 57 (standard deviation, 13; range, 29-81) years. All but one underwent a successful laparoscopic operation. Pathology included hepatocellular carcinoma (n=17), recurrent pyogenic cholangitis (n=14), colorectal liver metastasis (n=4), benign liver tumour (n=4), and intrahepatic cholangiocarcinoma (n=1). All except four were hand-assisted laparoscopic liver resections. The mean operating time was 169 (range, 60-290) minutes and mean blood loss amounted to 270 mL (range, 0-1000 mL). Complications occurred in eight (20%) patients, which included six wound infections, one postoperative bile leak, and two incisional hernias. There was no operative or hospital mortality. For hepatocellular carcinoma, clear resection (>10 mm) was achieved in all except five patients, and the 1-year and 2-year survival rates were 86% and 59% respectively. Favourable results were also obtained for resections in patients with recurrent pyogenic cholangitis; after a mean (standard deviation) follow-up of 29 (23) months, only one was readmitted (for cholangitis).
 
CONCLUSION. In appropriately selected patients, laparoscopic liver resection is feasible and safe, and achieves acceptable survival among individuals with hepatic malignancy and very favourable long-term outcomes in those with recurrent pyogenic cholangitis undergoing hand-assisted laparoscopic segmentectomy.
 
Key words: Carcinoma, hepatocellular; Cholangitis; Hepatectomy; Laparoscopy; Liver diseases
 
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Efficacy of multidisciplinary approach in treatment of constipation: a pilot study

ABSTRACT

Hong Kong Med J 2006;12:415-8 | Number 6, December 2006
ORIGINAL ARTICLE
Efficacy of multidisciplinary approach in treatment of constipation: a pilot study
PYY Lau, B Fung, WCS Meng, R Leung, AWC Yip, SP So, QSY Lee, D Chan
Department of Surgery, Kwong Wah Hospital, Hong Kong
 
 
OBJECTIVE. To evaluate a multidisciplinary Hong Kong treatment programme for patients with constipation.
 
DESIGN. Pilot study.
 
SETTING. A joint collaboration among the departments of surgery, physiotherapy, and dietetics in a regional hospital in Hong Kong.
 
PATIENTS. Thirty-one constipated patients with normal colonic transit and pelvic floor dyssynergia.
 
INTERVENTION. Multidisciplinary treatment including dietary modification, bowel habit adjustment, and physiotherapy.
 
MAIN OUTCOME MEASURES. Anorectal manometry, fibre intake, subjective improvement, bowel frequency, Bristol score, and straining time and effort.
 
RESULTS. Significant improvement was found in mean fibre intake, straining time and effort, but not in anal manometric results. A total of 78% of patients demonstrated more than 50% improvement in subjective symptoms, whereas 70% of the patients enjoyed objective improvement in pelvic floor dyssynergia documented by electromyography and anal pressure during a push effort.
 
CONCLUSION. The multidisciplinary rehabilitative programme for constipated patients significantly improved symptoms. Electromyography and anal pressure during a push effort are useful tools for objective assessment of the treatment effect.
 
Key words: Anal canal; Constipation; Digestive physiology; Rectum
 
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Surgical treatment of penile curvature

ABSTRACT

Hong Kong Med J 2006;12:410-4 | Number 6, December 2006
ORIGINAL ARTICLE
Surgical treatment of penile curvature
KL Ho, AWC Yip, LS Leung, IC Law
Department of Surgery, Kwong Wah Hospital, Yaumatei, Hong Kong
 
 
OBJECTIVE. To review long-term efficacy and complications of surgical treatment of penile curvature in a Chinese population.
 
DESIGN. Retrospective review.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. Patients who underwent surgical treatment of penile curvature between January 1997 and March 2005 inclusive.
 
INTERVENTION. Penile curvature corrective surgery.
 
MAIN OUTCOME MEASURES. Penile curvature recurrence, early and late complications.
 
RESULTS. Of 22 patients who underwent surgical treatment of penile curvatures, 19 had congenital and three had acquired diseases. The mean angle of deformity was 52.5 (range, 20-90) degrees. Ten patients had Nesbit procedures, ten had modified Nesbit procedures, and two underwent vein grafting. Twenty patients had residual or recurrent penile curvatures at a mean follow-up of 50.9 months. Fifteen patients had less than 30 degrees curvature and five had 30 to 60 degrees curvature. Early complications included wound infection (n=3), penile skin necrosis (n=1) treated by skin graft, and urethral injury (n=1). Three patients had erectile dysfunction; four complained of glans paraesthesia. Penile shortening (mean, 1.4 cm) and palpable knots were common late complications. A total of 19 patients were satisfied with the final outcomes.
 
CONCLUSIONS. Surgical treatment of penile curvature produces long-term patient satisfaction. Preoperative counselling on potential recurrence and common minor complications is crucial to produce favourable outcomes.
 
Key words: Penile diseases; Penile induration; Surgery
 
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Immuno-prophylaxis of babies borne to hepatitis B carrier mothers

ABSTRACT

Hong Kong Med J 2006;12:368-74 | Number 5, October 2006
ORIGINAL ARTICLE
Immuno-prophylaxis of babies borne to hepatitis B carrier mothers
K Tse, SLY Siu, KT Yip, SM Chan, TL Que, WYS Lui, PS Chan
Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, Hong Kong
 
 
OBJECTIVES. To examine the efficacy of current hepatitis B immuno-prophylaxis and estimate the prevalence of S-mutant infections among local newborn babies.
 
DESIGN. Prospective study.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. A total of 137 newborn babies delivered between the period of November 2000 and 30 June 2001 inclusive, whose mothers were chronic hepatitis B surface antigen carriers.
 
RESULTS. Of the 121 infants who were followed up for 12 months, three were found to be chronic hepatitis B virus carriers, giving a vertical transmission rate of 2.5%. One (0.8%) was suspected to be infected by the S-mutant. All the three hepatitis B virus carrier babies were born to mothers with hepatitis B e antigen, but none to the eight mothers suspected to have S-mutants. Of 119 (98.3%) infants who developed hepatitis B surface antibody upon follow-up at 12 months, 35 were found to have hepatitis B e antigen at birth. All were born to hepatitis B e antigen;ndash;positive mothers. Only three of the 35 babies were found to be hepatitis B virus carriers. Most babies lost the hepatitis B e antigen by 6 months of age; only the infected babies had the antigen persisting at 1 year of age. The non-infected infants' hepatitis B e antigen is likely transplacental.
 
CONCLUSIONS. Our hepatitis B virus prophylaxis programme was effective at preventing perinatal infection and the non-infected infants' hepatitis B e antigen was likely transplacental.
 
Key words: Hepatitis B e antigens; Hepatitis B surface antigens; Hepatitis B vaccines; Infant, newborn
 
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Uterine fibroid embolisation in Chinese women: medium-term results

ABSTRACT

Hong Kong Med J 2006;12:361-7 | Number 5, October 2006
ORIGINAL ARTICLE
Uterine fibroid embolisation in Chinese women: medium-term results
HLJ Mak, PCH Kwok, HHL Chau, MK Chan, SCH Chan, SCS Chan
Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
OBJECTIVE. To evaluate the medium-term results of uterine fibroid embolisation in Chinese women with symptomatic uterine fibroids.
 
DESIGN. Prospective case series study.
 
SETTING. Gynaecology and Interventional Radiology units in a public hospital, Hong Kong.
 
PATIENTS. Patients with symptomatic fibroids who underwent uterine fibroid embolisation in Queen Elizabeth Hospital from October 1998 to June 2004.
 
RESULTS. Fifty women (mean age, 42.9 years, median follow-up period, 27.5 months) were recruited. Most (82%) had menorrhagia as the chief presenting symptom. Embolisation was successful in 49 (98%) women. Complications occurred in 12 (24%) patients, but were all self-limiting. Significant decrease in the median clinical uterine size (14 weeks vs 10 weeks) and median volume of the largest fibroid on magnetic resonance imaging (157.9 mL vs 45 mL) were observed during the first year. The reduction seemed to be maintained till the last follow-up. Menorrhagia improved in 34 (84%) patients, dysmenorrhoea in 28 (88%), pelvic pain in 18 (82%) and abdominal mass in 15 (83%). Poor response was found for urinary symptoms (29% improvement). Eight (16%) patients underwent hysterectomies after uterine fibroid embolisation. On logistic regression analysis, the only significant predictive factor for symptomatic improvement was fibroid volume reduction at 6 months (P=0.03).
 
CONCLUSION. Uterine fibroid embolisation is an effective uterine-preserving therapy in patients with symptomatic fibroids; overall symptomatic improvement was estimated as 80%. Uterine or fibroid size reduction correlated well with clinical outcome. The impact of uterine fibroid embolisation on young women wishing to conceive is yet to be determined.
 
Key words: Embolization, therapeutic; Leiomyoma; Magnetic resonance imaging; Uterus; Women
 
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The short-to-midterm results of endovascular stent grafting for acute thoracic aortic diseases in Chinese patients

ABSTRACT

Hong Kong Med J 2006;12:355-60 | Number 5, October 2006
ORIGINAL ARTICLE
The short-to-midterm results of endovascular stent grafting for acute thoracic aortic diseases in Chinese patients
PCH Kwok, KK Ho, CC Ma, SS Chung, CCW Tse, PLF Tang, FSK Cheng, SCH Chan
Department of Radiology and Imaging, Queen Elizabeth Hospital, Hong Kong
 
 
OBJECTIVE. To review the results of endovascular treatment of acute thoracic aortic diseases in a group of Chinese patients.
 
DESIGN. Retrospective study.
 
SETTING. A tertiary referral hospital with a cardiothoracic surgery service.
 
PATIENTS. All 15 patients presenting with acute thoracic aortic diseases between September 2001 and October 2005 inclusive, of whom eight had traumatic rupture, four had complicated acute dissections, two had mycotic aneurysms, and one an aneurysm with an aortobronchial fistula.
 
INTERVENTIONS. Thoracic aortic stent grafting.
 
MAIN OUTCOME MEASURES. Immediate success, 6-month and 1-year survival rates.
 
RESULTS. The median follow-up period was 20.6 months (range, 0-50.1 months). Stent grafts were deployed with immediate success in all patients. Two patients had ancillary bypass surgery for the supra-aortic branches. There were two in-hospital deaths. Four sustained access artery injury and needed graft repair. Computed tomography at 1 month showed complete thrombosis of the aneurysmal lumen or the thoracic aortic false lumen in 12 of 13 survivors. Computed tomography at 6 months showed complete thrombosis of the aneurysmal lumen or the false lumen in nine of 10 patients due for follow-up. Both 6-month and 1-year survival rates were 87%.
 
CONCLUSIONS. Thoracic aortic stent grafting for acute thoracic aortic disease is feasible and has a high success rate, with good short-to-midterm results. However, the large size of the stent graft introducer set imposes a high risk of access artery injury, for which further improvements are necessary.
 
Key words: Aneurysm, dissecting; Aneutysm, false; Aortic aneurysm, thoracic; Blood vessel prosthesis implantation; Follow-up studies
 
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Hong Kong men with low incomes have worse health-related quality of life as judged by SF-36 scores

ABSTRACT

Hong Kong Med J 2006;12:351-4 | Number 5, October 2006
ORIGINAL ARTICLE
Hong Kong men with low incomes have worse health-related quality of life as judged by SF-36 scores
GTC Ko, HPS Wai, PCC Tsang, HCK Chan
Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong
 
 
OBJECTIVE. To analyse the association between income and health-related quality of life using the Medical Outcome Study Short Form 36 (SF-36) Chinese version in Hong Kong Chinese working population.
 
DESIGN. Cross-sectional observation study.
 
SETTING. A commercial company in Hong Kong.
 
PARTICIPANTS. All clerical and administrative staff of a commercial company was invited to participate; 876 of the 1003 staff agreed. The subjects were categorised into three income groups according to monthly income in Hong Kong dollars (low, <=10 000; middle, >10 000-25 000; high, >25 000). The mean age of the 288 men and 588 women was 34.9 (standard deviation, 7.9; median, 34.0; range, 18-71) years.
 
MAIN OUTCOME MEASURES. SF-36 scores on health-related quality of life.
 
RESULTS. The distribution of income was 30% in high-, 54.8% in middle-, and 15.2% in low-income groups. Women had similar SF-36 scores among different income groups. In men, for most variables there was a significant positive linear correlation between income and SF-36 scores.
 
CONCLUSION. Low income is associated with a worse health-related quality of life in Hong Kong Chinese men.
 
Key words: Asian continental ancestry group; Hong Kong; Income; Quality of life
 
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Sublingual misoprostol compared to artificial rupture of membrames plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term

ABSTRACT

Hong Kong Med J 2006;12:345-50 | Number 5, October 2006
ORIGINAL ARTICLE
Sublingual misoprostol compared to artificial rupture of membrames plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term
TK Lo, WL Lau, KS Wong, LCH Tang
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong
 
 
OBJECTIVE. To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term.
 
DESIGN. Open randomised controlled trial.
 
SETTING. Regional hospital, Hong Kong. PATIENTS. Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indications for labour induction.
 
INTERVENTIONS. With their informed consent, 100 eligible women were to be randomised to receive either sublingual misoprostol 50 micrograms every 4 hours for up to five doses or oxytocin infusion after artificial rupture of membranes. Interim analysis was planned at a sample size of 50.
 
MAIN OUTCOME MEASURES. Vaginal delivery within 24 hours of induction.
 
RESULTS. The study was terminated when interim analysis of the first 50 recruits showed that a significantly smaller proportion of misoprostol-treated women delivered vaginally within 24 hours of induction than in the conventional treatment group (68% vs 100%; relative risk, 0.68; 95% confidence interval, 0.51-0.91; P=0.009), although comparable numbers of women eventually delivered vaginally. The mean induction to vaginal delivery interval was 4.5 hours longer in the misoprostol group (P=0.027). After misoprostol treatment, all women went into labour. Forty percent of them delivered without oxytocin. There was no significant difference in uterine hyperstimulation rate, operative delivery rate, and neonatal outcomes. Maternal satisfaction was higher in the misoprostol group (92% vs 60%; relative risk, 1.53; 95% confidence interval, 1.09-2.16; P=0.008).
 
CONCLUSIONS. Despite being well accepted by women, labour induction using this regimen of sublingual misoprostol is less effective in achieving vaginal delivery within 24 hours.
 
Key words: Cervix uteri; Labor, induced; Misoprostol; Oxytocin
 
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Twelve years' local experience in ambulatory anaesthesia

ABSTRACT

Hong Kong Med J 2006;12:339-44 | Number 5, October 2006
ORIGINAL ARTICLE
Twelve years' local experience in ambulatory anaesthesia
AKW Lai, V Ho, YF Chow
Department of Anaesthetia, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong
 
 
OBJECTIVES. To determine the incidence of adverse events after ambulatory anaesthesia (postoperative nausea and vomiting, postoperative pain, difficulty in movement), and to evaluate the level of satisfaction of patients with our service.
 
DESIGN. Retrospective study with questionnaire survey.
 
SETTING. Tertiary referral centre, Hong Kong.
 
PARTICIPANTS. All patients whose duly completed questionnaires were available.
 
MAIN OUTCOME MEASURES. Incidence of adverse events and level of patient satisfaction.
 
RESULTS. A total of 9197 patients underwent surgery under general anaesthesia or neuraxial blockade by anaesthetists in ambulatory settings from October 1993 to December 2005: questionnaires filled out by 8231 of these patients were analysed, whereas 549 questionnaires were lost, and 417 patients could not be contacted. The response rate was 90%; 59% of the respondents were males, 50% were younger than 15 years and 5% older than 60 years. Fifty-one percent of surgery with anaesthetists' involvement was performed under general anaesthesia and 48.9% under general anaesthesia and regional blocks and 0.1% under neuraxial blockade. There were 3.3% of patients experienced postoperative nausea and vomiting, 60.2% experienced episodes of pain between the time of discharge and the time of interview, and 46% required analgesics. Nonetheless, 80% resumed normal activities within 5 hours after anaesthesia and 97.5% resumed normal diet the following morning. Over 99% rated our service as good or excellent.
 
CONCLUSION. Although ambulatory anaesthesia was associated with minor adverse events, patients could resume normal diet and daily activities quickly and were satisfied with the service.
 
Key words: Ambulatory care; Ambulatory surgical procedures; Anesthesia; Postoperative nausea and vomiting
 
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