Epidemiology of occupational hand injury in Hong Kong

ABSTRACT

Hong Kong Med J 2012;18:131–6 | Number 2, April 2012
ORIGINAL ARTICLE
Epidemiology of occupational hand injury in Hong Kong
Rajesh Garg, Jason PY Cheung, Boris KK Fung, WY Ip
Department of Orthopaedics and Traumatology, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong
 
 
OBJECTIVES. To study the epidemiology of occupational hand injuries and associated social and industrial factors.
 
DESIGN. For this retrospective case series of patients with occupational hand injuries, case records were retrieved to gather data. In addition, all the subjects were interviewed by a single interviewer using a predesigned questionnaire.
 
SETTING. Division of Hand Surgery, Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
 
PATIENTS. A total of 250 patients with occupational hand injuries were treated during the period from 1999 to 2001. This period was chosen to obtain 10 years of follow-up data to assess return to work and any secondary injuries.
 
MAIN OUTCOME MEASURES. Personal particulars (gender, age, marital status, education level, length of stay in Hong Kong, type of employment, wage system, personal habits, family size, number of breadwinners, income), type of industry and mode of injury, causes of injury according to the worker, work conditions, type of injury, and treatment given.
 
RESULTS. Two groups of workers in our study had more occupational hand injuries, namely those with less than 1 year of experience on a new job and immigrants from China. Factors associated with a large proportion of occupational hand injuries were male gender with personal risk factors (smoking and regular consumption of alcohol, long working hours), and in the case of machine operators, inadequate training and use of safety devices.
 
CONCLUSION. Occupational hand injuries lead to loss of working hours and compensation. For prevention, the workplace should be made into a safer and work-friendly environment. Workers should also have sufficient training.
 
Key words: Accidents, occupational; Hand injuries; Life style; Risk factors; Wounds and injuries
 
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The Chinese version of the pelvic pain and urgency/frequency symptom scale: a useful assessment tool for street-ketamine abusers with lower urinary tract symptoms

ABSTRACT

Hong Kong Med J 2012;18:123–30 | Number 2, April 2012
ORIGINAL ARTICLE
The Chinese version of the pelvic pain and urgency/frequency symptom scale: a useful assessment tool for street-ketamine abusers with lower urinary tract symptoms
CM Ng, WK Ma, KC To, MK Yiu
Division of Urology, Department of Surgery, Princess Margaret Hospital, Laichikok, Kowloon, Hong Kong
 
 
OBJECTIVE. To investigate the use of a translated Chinese version of the pelvic pain and urgency/frequency symptom scale as an assessment and prognostic tool to evaluate the severity of street-ketamine-associated lower urinary tract symptoms and their reversibility after abstinence.
 
DESIGN. Cross-sectional study.
 
SETTING. A special designated out-patient clinic in a regional hospital in Hong Kong.
 
PARTICIPANTS. There were 50 patients with street-ketamine-associated lower urinary tract symptoms and 20 healthy individuals.
 
MAIN OUTCOME MEASURES. Reliability and validity of the questionnaire; frequency of individual lower urinary tract symptoms, cystoscopic, urodynamic and radiological abnormalities, and their correlation with pelvic pain and the urgency/frequency score.
 
RESULTS. The test-retest reliability coefficient was 0.755 (P<0.001). Cronbach's alpha was 0.974. Mann-Whitney U test proved the discriminatory ability of the questionnaire (P<0.001). Patients with specific lower urinary tract symptoms had a higher mean pelvic pain and urgency/frequency total score compared to those without them: frequency (23.8 vs 17.3), nocturia (22.4 vs 14.0), urgency (22.5 vs 15.1), dysuria (22.7 vs 13.3), and haematuria (24.8 vs 16.2). The number of daytime voids and nocturia episodes correlated well with pelvic pain and urgency/frequency scores. With an increasing score, the likelihood of having cystitis changes, urodynamic abnormalities and hydronephrosis increased, while the cystometrically determined bladder capacity decreased. None of the patients with a score of 16 or below had urodynamic abnormality or hydronephrosis. The mean score change in the abstinence group was -4.33, versus +3.33 in their counterparts.
 
CONCLUSIONS. Theme Chinese version of the pelvic pain and urgency/frequency questionnaire is reliable and valid for assessment in patients with street-ketamine-associated lower urinary tract symptoms. The pelvic pain and urgency/frequency score correlates well with symptom severity as well as endoscopic, urodynamic and radiological abnormalities in patients with street-ketamine-associated lower urinary tract symptoms. A cut-off total pelvic pain and urgency/frequency score of 17 may suggest more serious urological sequelae from ketamine abuse. Abstinence from ketamine reduced lower urinary tract symptoms, but the extent of reversibility of urinary tract damage is yet to be evaluated.
 
Key words: Ketamine; Lower urinary tract symptoms; Questionnaires; Sensitivity and specificity; Substance-related disorders
 
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Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients

ABSTRACT

Hong Kong Med J 2012;18:115–22 | Number 2, April 2012
ORIGINAL ARTICLE
Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients
Andy CO Cheng, Noel CY Chan, Carmen KM Chan
Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
 
 
OBJECTIVE. Inflammation of the optic nerve (optic neuritis) and its sheath (optic perineuritis) can have similar initial clinical presentations. They are less well-defined in the Chinese than in Caucasians, and the aetiology of optic neuritis may also differ depending on ethnicity. The aim of our study was to document the clinical features of acute/subacute optic neuritis/optic perineuritis in Chinese patients.
 
DESIGN. Retrospective case series.
 
SETTING. Hong Kong Eye Hospital, Hospital Authority.
 
PATIENTS. Records of all patients presenting to the Hong Kong Eye Hospital between 2005 and 2008, with their first episode of optic neuritis/optic perineuritis with onset of symptoms within 30 days, were reviewed.
 
MAIN OUTCOME MEASURES. Disease aetiology, clinical features and outcomes.
 
RESULTS. Twenty-nine patients were included (M:F=13:16), with a mean age of 46 years at presentation. Among these, 25 had optic neuritis and four had optic perineuritis; four presented with bilateral optic neuritis. Among the optic neuritis group, 17 (68%) were idiopathic, seven (28%) were related to multiple sclerosis, and one (4%) had neuromyelitis optica. Poor visual outcome in the optic neuritis group was associated with poor visual acuity at presentation and poor visual acuity at the nadir.
 
CONCLUSION. Optic perineuritis and neuromyelitis optica-related optic neuritis were more commonly encountered in our study of Hong Kong Chinese patients than in Caucasian populations. Even in Chinese patients with 'typical' optic neuritis, neuroimaging and further investigations may be warranted to exclude optic perineuritis/neuromyelitis optica, since Chinese ethnicity is itself an atypical feature. Where neuro-imaging is not readily available, intravenous methylprednisolone may be considered as initial treatment to cover both optic neuritis/optic perineuritis in patients with severe visual loss.
 
Key words: Multiple sclerosis; Optic nerve; Optic neuritis; Visual acuity
 
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Tight control early rheumatoid arthritis clinic in Hong Kong: a pilot study

ABSTRACT

Hong Kong Med J 2012;18:108–14 | Number 2, April 2012
ORIGINAL ARTICLE
Tight control early rheumatoid arthritis clinic in Hong Kong: a pilot study
Kitty Y Kwok, MH Leung
Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
OBJECTIVE. To evaluate disease activity in early rheumatoid arthritis patients in daily practice 1 year after applying a tight control treatment strategy aimed at lowering disease activity (Disease Activity Score 28, ≤3.2).
 
DESIGN. Single-arm open trial with historical controls.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All new rheumatoid arthritis patients (onset <2 years) attending the tight control clinic from October 2008 to October 2009 were recruited. All the patients were followed up every 3 to 6 weeks and clinically assessed using the Disease Activity Score 28. Disease-modifying agent treatment was stepped up according to a preset protocol ladder and patient tolerance. The treatment target was to achieve a Disease Activity Score 28 of 3.2 or below (low disease activity). These patients were compared to matched historical controls in the rheumatology clinic.
 
RESULTS. Twenty patients in the tight control early rheumatoid arthritis clinic were recruited. Their disease activities were brought into better control than historical control patients who were followed up every 12 weeks. At week 52, clinical variables showed greater improvements in the intensive care group; respective mean scores (based on the Disease Activity Score 28 system) were 2.7 versus 4.2 (P<0.001); respective mean Health Assessment Questionnaire scores were 0.2 versus 1.3 (P<0.001).
 
CONCLUSIONS. Outcomes of patients attending our locally adapted tight control clinic were consistent with previous reports in the literature. The clinic reduced rheumatoid arthritis activity faster and better. It entailed more frequent follow-up and monitoring, however. To address this strategy more objectively, a randomised trial with parallel controls is necessary.
 
Key words: Antirheumatic agents; Arthritis, rheumatoid; Drug therapy, combination; Early diagnosis; Prognosis
 
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Factors influencing the mode of delivery and associated pregnancy outcomes for twins: a retrospective cohort study in a public hospital

ABSTRACT

Hong Kong Med J 2012;18:99–107 | Number 2, April 2012
ORIGINAL ARTICLE
Factors influencing the mode of delivery and associated pregnancy outcomes for twins: a retrospective cohort study in a public hospital
AL Liu, WK Yung, HN Yeung, SF Lai, MT Lam, FK Lai, TK Lo, WL Lau, WC Leung
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong
 
 
OBJECTIVES. To determine current trends for different modes of delivery in twin pregnancies, factors affecting the mode of delivery, and associated outcomes.
 
DESIGN. Retrospective cohort study.
 
SETTING. A public hospital in Hong Kong.
 
PARTICIPANTS. All twin pregnancies booked at Kwong Wah Hospital during a 3-year period from 1 April 2006 to 31 March 2009.
 
RESULTS. Of 197 sets of twins, 35 (18%) were delivered vaginally and 162 (82%) by caesarean section (47% were emergencies and 53% elective). In all, 32 (37%) of the elective and 21 (28%) of the emergency caesarean sections were in response to maternal requests. Vaginal delivery was more common in mothers with a history of vaginal delivery and monochorionic diamniotic twins. Women who conceived by assisted reproduction or those who had a tertiary education were more likely to deliver by caesarean section. The type of conception and the presentation of the second twin were statistically significant factors affecting maternal choice on the mode of delivery. Maternal age did not affect the choice of delivery mode. Except for the higher frequency of sepsis and cord blood acidosis in second twins delivered vaginally, there were no significant differences in neonatal morbidity between the groups that attempted vaginal delivery or requested caesarean sections. All the women who had compression sutures or hysterectomy to control massive postpartum haemorrhage were delivered by caesarean section.
 
CONCLUSION. A high caesarean section rate observed in our cohort was associated with maternal requests for this mode of delivery. The type of conception and the presentation of the second twin were statistically significant factors affecting maternal choice on mode of delivery. Women's requests for caesarean delivery out of the concern for their babies are not supported by current evidence. In response to a woman with a twin pregnancy requesting caesarean delivery, the pros and cons of vaginal deliveries and caesarean sections should be fully explained before the woman's autonomy is respected.
 
Key words: Cesarean section; Delivery, obstetric; Pregnancy, multiple; Reproductive techniques, assisted; Twins
 
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Is stroke thrombolysis safe and efficacious in Hong Kong?

ABSTRACT

Hong Kong Med J 2012;18:92–8 | Number 2, April 2012
ORIGINAL ARTICLE
Is stroke thrombolysis safe and efficacious in Hong Kong?
Edward HC Wong, Alexander YL Lau, Yannie OY Soo, Deyond YW Siu, Venus SW Hui, Colin A Graham, Thomas WH Leung, Lawrence KS Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To investigate the safety and efficacy of stroke thrombolysis in a local hospital.
 
DESIGN. Historical cohort study.
 
SETTING. A tertiary hospital in Hong Kong.
 
PATIENTS. The outcome of acute ischaemic stroke patients treated with intravenous tissue plasminogen activator between October 2008 and May 2011 was compared to those admitted during the same period who were thrombolysis-eligible, but treated conservatively due to unavailability of the thrombolysis service after-hours.
 
INTERVENTIONS. Intravenous tissue plasminogen activator.
 
MAIN OUTCOME MEASURES. Primary outcome was functional independence (modified Rankin Scale score of 2 or below) at 3 months. Safety outcomes were symptomatic intracranial haemorrhage and 3-month mortality. Secondary outcomes were hospital length of stay, direct home discharge, and nursing home discharge.
 
RESULTS. A total of 48 thrombolysis and 63 non-thrombolysis patients were identified. Fifty-two percent of the thrombolysis group achieved functional independence compared to 24% of nonthrombolysis group (P=0.003), without significant increase in mortality (15% vs 13%, P=0.51) or symptomatic intracranial haemorrhage (4% vs 2%, P=0.58). Twenty-nine percent of the thrombolysis group patients were discharged home directly, versus 6% of non-thrombolysis group (P<0.001). Mean length of stay was shorter for the thrombolysis group (25 vs 35 days; P=0.034). A similar percentage from each group was discharged to nursing homes.
 
CONCLUSION. Implementation of the stroke thrombolysis service in Hong Kong appeared safe and efficacious. Patients who received thrombolysis had better outcomes compared to non-thrombolysis cohort. Further studies are needed to investigate the economics of stroke thrombolysis in Hong Kong, which may help to improve funding for provision of this service.
 
Key words: Brain ischemia; Hong Kong; Stroke; Tissue plasminogen activator; Thrombolytic therapy
 
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Surgical ablation of hepatocellular carcinoma with 2.45-GHz microwave: a critical appraisal of treatment outcomes

ABSTRACT

Hong Kong Med J 2012;18:85–91 | Number 2, April 2012
ORIGINAL ARTICLE
Surgical ablation of hepatocellular carcinoma with 2.45-GHz microwave: a critical appraisal of treatment outcomes
KF Lee, Joyce WY Hui, YS Cheung, Jeff SW Wong, CN Chong, John Wong, Simon CH Yu, Paul BS Lai
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
OBJECTIVE. To evaluate the efficacy and safety of a new generation of 2.45-GHz microwave to ablate hepatocellular carcinoma by surgical approach.
 
DESIGN. Case series with prospective follow-up.
 
SETTING. A university teaching hospital in Hong Kong.
 
PATIENTS. From March 2009 to January 2011, 26 consecutive patients (19 men and 7 women) with a median age of 63 (range, 49-79) years with hepatocellular carcinoma were recruited. Five (19%) of the patients had recurrent hepatocellular carcinoma after previous treatment.
 
INTERVENTION. Microwave ablation for hepatocellular carcinomas (one tumour, n=24; two tumours, n=2) using a laparoscopic (n=16) or open approach (n=10).
 
MAIN OUTCOME MEASURES. Operative mortality and morbidity, rate of incomplete ablation, recurrence rate, and survival rate.
 
RESULTS. The median tumour diameter was 3.8 cm (range, 2.0-6.0 cm). Complications occurred in five (19%) of the patients; only one was ablation-related, and there was no operative mortality. One (4%) of the patients experienced incomplete ablation. Recurrent tumours were noted in 11 (42%) of the patients (5 were local, 2 were remote, and 4 were multifocal) after a median follow-up of 14 (range, 4-26) months. The failure rate for local disease control was 23%, and was 14% if patients with recurrent hepatocellular carcinoma were excluded. All but one patient survived until the time of censorship. The mean survival was 25 (standard deviation, 1) months.
 
CONCLUSION. This new-generation microwave technique is safe and effective for local ablation of hepatocellular carcinoma. It is a valuable treatment option for patients who are not candidates for hepatectomy.
 
Key words: Ablation techniques; Carcinoma, hepatocellular; Liver neoplasms; Microwaves
 
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Green pit viper antivenom from Thailand and Agkistrodon halys antivenom from China compared in treating Cryptelytrops albolabris envenomation of mice

ABSTRACT

Hong Kong Med J 2012;18:40–5 | Number 1, February 2012
ORIGINAL ARTICLE
Green pit viper antivenom from Thailand and Agkistrodon halys antivenom from China compared in treating Cryptelytrops albolabris envenomation of mice
HT Fung, WH Yung, Paul Crow, KK Lam, Kenny KW Ho, KS Tan, SK Lam, Y Ke, Alessandro Grioni, OF Wong, Gary Ades, CW Kam, ML Tse
Department of Accident and Emergency, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
OBJECTIVE. To compare the relative efficacy of the green pit viper antivenom from Thailand and Agkistrodon halys antivenom from China.
 
DESIGN. In-vivo experimental study.
 
SETTING. A wildlife conservation organisation, a university, a poison information centre, and a regional hospital in Hong Kong.
 
MAIN OUTCOME MEASURES. Pre- and post-antivenom lethal dose 50 (LD50) of the Cryptelytrops albolabris venom, median effective dose (ED50) of green pit viper antivenom and Agkistrodon halys antivenom against a lethal dose of the venom.
 
SUBJECTS. Adult mice.
 
RESULTS. The intraperitoneal LD50 of the venom from locally caught Cryptelytrops albolabris was 0.14 microL. After post-exposure treatment with 10 microL of antivenom, it was elevated to 0.36 microL and 0.52 microL by the green pit viper antivenom and the Agkistrodon halys antivenom, respectively. The ED50 was 32.02 microL for green pit viper antivenom and 6.98 microL for Agkistrodon halys antivenom. Both green pit viper antivenom and Agkistrodon halys antivenom ameliorated the lethality of Cryptelytrops albolabris venom in mice.
 
CONCLUSION. The overall superior neutralisation capacity of Agkistrodon halys antivenom over green pit viper antivenom may be related to the geographic proximity of the venoms used for antivenom preparation. The results point towards the need for further comparison of the two antivenoms on protein or immunoglobulin weight basis, and with respect to non-lethal clinically significant toxicities.
 
Key words: Antivenins; Cross reactions; Crotalid venoms; Neutralization; Snake bites
 
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Serial transverse enteroplasty for short bowel syndrome: Hong Kong experience

ABSTRACT

Hong Kong Med J 2012;18:35–9 | Number 1, February 2012
ORIGINAL ARTICLE
Serial transverse enteroplasty for short bowel syndrome: Hong Kong experience
Michael WY Leung, Ivy HY Chan, Nicholas SY Chao, Beatrice PY Wong, Kelvin KW Liu
Division of Paediatric Surgery, Department of Surgery, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong
 
 
OBJECTIVE. To report our experience with the first series of serial transverse enteroplasty operations (a novel bowel-lengthening procedure for patients with short bowel syndrome).
 
DESIGN. Case series.
 
SETTING. A tertiary paediatric surgery referral centre in Hong Kong.
 
PATIENTS. Four patients with short bowel syndrome aged 11 months to 14 years underwent serial transverse enteroplasty between November 2007 and June 2010.
 
RESULTS. A total of six such serial procedures were performed; two patients had repeated operations. Median pre-serial transverse enteroplasty small bowel length was 17.5 cm. The median increase in small bowel length was 90%. One patient experienced transient postoperative intestinal obstruction that resolved after conservative management. The median postoperative follow-up period was 31 months. The median enteral nutrition tolerance increased from 24% to 47%. The median weight-for-age z score increased by 0.55, and the median weight-for-height z score increased by 0.98. One patient had successfully weaned off parenteral nutrition.
 
CONCLUSION. Serial transverse enteroplasty is a feasible and safe treatment for short bowel syndrome patients, which helps to improve enteral nutrition and promote growth. Repeated serial transverse enteroplasty can be performed in patients with ultra-short bowel lengths. Follow-up is necessary to assess the long-term outcomes.
 
Key words: Intestinal obstruction; Intestine, small; Reconstructive surgical procedures; Short bowel syndrome
 
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Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap

ABSTRACT

Hong Kong Med J 2012;18:30–4 | Number 1, February 2012
ORIGINAL ARTICLE
Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap
TW Chiu, Czarina CH Leung, Edgar YK Lau, Andrew Burd
Plastic Reconstructive and Aesthetic Surgery, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To investigate gabapentin's role in head and neck cancer surgery following the demonstration of the effectiveness of gabapentin in reducing postoperative pain.
 
DESIGN. Non-randomised open-label trial.
 
SETTING. Prince of Wales Hospital, Hong Kong.
 
MAIN OUTCOME MEASURES. Pain scores, analgesic usage, and the frequency of adverse effects.
 
PATIENTS. In patients undergoing anterolateral thigh flap reconstruction after resection of tongue carcinoma, those who had an oral dose of gabapentin before surgery were compared to those who did not.
 
RESULTS. Postoperative pain was reduced in the gabapentin group (1.2) compared to the control group (1.7) [P=0.05]. In the gabapentin group, mean morphine (patient-controlled analgesia) use (3.5 mg), sedation scores (1.0), and antiemetic usage (0 mg metoclopramide) were all significantly reduced in comparison to the controls with respective figures of 11.4 mg, 1.6, and 12.2 mg.
 
CONCLUSION. Single preoperative doses of gabapentin led to significant reductions in postoperative pain and nausea with reduced analgesic and antiemetic usage, without additional side-effects or increases in operative complications.
 
Key words: Acetic acids; Analgesics; gamma-Aminobutyric acid; Head and neck neoplasms; Pain, postoperative
 
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