Metastatic Crohn's disease in a Chinese girl

ABSTRACT

Hong Kong Med J 2006;12:467-9 | Number 6, December 2006
CASE REPORT
Metastatic Crohn's disease in a Chinese girl
JTHT Yu, LY Chong, KC Lee
Yaumatei Dermatology Clinic, 12/F, Yaumatei Specialist Clinic, 143 Battery Street, Kowloon, Hong Kong
 
 
Metastatic Crohn's disease, in which non-caseating granulomatous infiltration of the skin occurs at sites separated from the gastro-intestinal tract by normal tissue, is the least common dermatologic manifestation of Crohn's disease. We report a 15-year-old girl with metastatic Crohn's disease presenting as granulomatous vulvar papules and nodules with typical histopathologic features. To the best of our knowledge, this is the first case of metastatic Crohn's disease in Chinese children reported in the English medical literature.
 
Key words: Crohn's disease
 
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Child slavery in Hong Kong: case report and historical review

ABSTRACT

Hong Kong Med J 2006;12:463-6 | Number 6, December 2006
CASE REPORT
Child slavery in Hong Kong: case report and historical review
ACW Lee, KT So
Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
An 11-year-old girl was admitted with multiple injuries sustained during a 1-year servitude of domestic labour. She was acquired from her parents in Mainland China by a relative in Hong Kong. The child's parents received a sum of money that the child had to repay with work. Her hardship was characterised by long hours of incessant labour and physical torture when she failed to meet the demands of her mistress or her mistress' children. This case resembles Mui Tsai, a form of child slavery and exploitative domestic labour that was rife in Hong Kong a century ago, and illustrates the new challenges to child rights and protection consequent to the increasing social and economic integration between the Hong Kong Special Administrative Region and Mainland China.
 
Key words: Child abuse; Social problems; Torture
 
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Subchondral insufficiency fracture of the femoral head

ABSTRACT

Hong Kong Med J 2006;12:460-2 | Number 6, December 2006
CASE REPORT
Subchondral insufficiency fracture of the femoral head
CC Chan, A Li, WC Fan, LK Sun, HC Cheng, JCS Chan
Department of Radiology, United Christian Hospital, Hong Kong
 
 
Subchondral insufficiency fracture of the femoral head is a recently recognised entity. There are a few cases reported in Japanese and Caucasian patients but none in the Hong Kong population. The condition typically occurs in elderly females with osteoporosis. Acute hip pain is the usual presentation. The patient may have concomitant insufficiency fractures elsewhere. Magnetic resonance imaging is usually required to make the diagnosis. The prognosis of the condition is unknown. Reported complications include rapid collapse of the femoral head and coxopathy. Joint replacement should be considered if conservative management fails.
 
Key words: Femoral neck fractures; Osteoporosis
 
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Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones

ABSTRACT

Hong Kong Med J 2006;12:394-7 | Number 5, October 2006
CASE REPORT
Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones
TH Kwan, MKH Tong, KT Leung, CK Lai, WT Poon, YW Chan, WH Lo, TC Au
Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
Chinese herbal medicine preparations are widely available and often regarded by the public as natural and safe remedies for a variety of medical conditions. Nephropathy caused by Chinese herbs has previously been reported, usually involving the use of aristolochic acids. We report a 23-year-old woman who developed acute renal failure following prolonged use of a proprietary Chinese herbal slimming pill that contained anthraquinone derivatives, extracted from Rhizoma Rhei (rhubarb). The renal injury was probably aggravated by the concomitant intake of a non-steroidal anti-inflammatory drug, diclofenac. Renal pathology was that of hypocellular interstitial fibrosis. Spontaneous renal recovery occurred upon cessation of the slimming pills, but mild interstitial fibrosis and tubular atrophy was still evident histologically 4 months later. Although a causal relationship between the use of an anthraquinone-containing herbal agent and renal injury remains to be proven, phytotherapy-associated interstitial nephropathy should be considered in patients who present with unexplained renal failure.
 
Key words: Drugs, Chinese herbal; Kidney failure, acute; Nephritis, interstitial; Obesity/drug therapy; Phytotherapy
 
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Typhoid osteomyelitis of the lumbar spine

ABSTRACT

Hong Kong Med J 2006;12:391-3 | Number 5, October 2006
CASE REPORT
Typhoid osteomyelitis of the lumbar spine
FY Khan, AH EL-Hiday, HA Kamel
Department of Medicine, Hamad General Hospital, Doha, Qatar
 
 
A 25-year-old Nepali man presented with a 20-day history of fever associated with a lower backache. Physical examination found tenderness over the lower lumbar vertebrae. Magnetic resonance imaging following intravenous contrast injection showed enhancement of the L4 and L5 vertebrae, particularly pronounced around the intervening disc, and areas of endplate erosion. Extra-vertebral enhancement and a small subligamentous anterior collection were also noted. Computed tomography-guided needle aspiration was performed at the level of L4/5 disc material and culture of the specimen grew Salmonella typhi sensitive to ampicillin, ciprofloxacin, and ceftriaxone. The patient received intravenous ampicillin 2 g per 4 hours for 6 weeks. The back pain resolved completely and the patient was discharged. Typhoid osteomyelitis of the spine should be considered in the differential diagnosis in patients from endemic areas who present with fever and backache.
 
Key words: Osteomyelitis; Salmonella infections; Typhoid fever
 
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A case of takotsubo cardiomyopathy: transient left ventricular apical ballooning

ABSTRACT

Hong Kong Med J 2006;12:388-90 | Number 5, October 2006
CASE REPORT
A case of takotsubo cardiomyopathy: transient left ventricular apical ballooning
KCH Lau, KKH Yiu, KL Lee, RLY Ko, YM Lam, L Lam, SWL Lee
Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
 
 
A 78-year-old woman was admitted to hospital with central chest pain and the electrocardiographic and cardiac marker changes typical of acute anterior myocardial infarction. Coronary angiography revealed normal epicardial coronary arteries, and left ventriculography showed apical akinesis as well as basal hyperkinesis. This is a case of transient left ventricular apical ballooning or takotsubo cardiomyopathy, possibly attributable to catecholamine-mediated myocardial stunning.
 
Key words: Cardiomyoppathies; Catecholamines, Myocardial infarction; Ventricular dysfunction, left
 
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Autoimmune polyendocrinopathy type II in a Chinese patient

ABSTRACT

Hong Kong Med J 2006;12:385-7 | Number 5, October 2006
CASE REPORT
Autoimmune polyendocrinopathy type II in a Chinese patient
CC Tsang, GTC Ko, KK Wong, HS Chan, AWY Yu
Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, 11 Chuen On Road, Tai Po, Hong Kong
 
 
Autoimmune polyendocrinopathy type II is rarely reported in Chinese patients. A 42-year-old Chinese woman with a history of Hashimoto's thyroiditis and hypogonadotropic hypogonadism presented with pneumonia. During hospitalisation, she went into an adrenal crisis and diabetic ketoacidosis. Subsequent dynamic hormonal tests revealed primary and secondary adrenal insufficiency. She also had pernicious anaemia, possible alopecia areata, and myasthenia gravis. This constellation of multiple endocrine and non-endocrine disorders led to the diagnosis of autoimmune polyendocrinopathy type II. As the syndrome can be lethal, it is important to maintain a high index of suspicion, enabling early diagnosis and the appropriate replacement therapy, to ensure a successful outcome.
 
Key words: Adrenal insufficiency; Anemia, pernicious, Diabetes mellitus; Polyendocrinopathies, autoimmune; Thyroiditis, autoimmune
 
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Ex-utero intrapartum treatment: a controlled approach to the management of anticipated airway problems in the newborn

ABSTRACT

Hong Kong Med J 2006;12:381-4 | Number 5, October 2006
CASE REPORT
Ex-utero intrapartum treatment: a controlled approach to the management of anticipated airway problems in the newborn
GM Chu, V Yue, V Addullah, HB Chan, WK To, MY Chan, A Kwan
Department of Otorhinolaryngology, United Christian Hospital, Kwun Tong, Hong Kong
 
 
Airway problems in an unborn foetus that may cause obstruction can be safely managed using an ex-utero intrapartum technique. Advanced technology now allows many congenital airway problems to be diagnosed in the prenatal period. Careful prenatal planning of an ex-utero intrapartum treatment allows safe airway control while the foetus remains on uteroplacental support. It avoids the need for emergent intervention of an acutely obstructed airway in a neonate that often has disastrous consequences.
 
Key words: Airway obstruction; Fetus/surgery, Head and neck neoplasms; Lymphangioma, cystic; Tracheostomy
 
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Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies

ABSTRACT

Hong Kong Med J 2006;12:319-21 | Number 4, August 2006
CASE REPORT
Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies
FMF Cheung, L Ma, WC Wu, TH Siu, PT Choi, YP Tai
Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
A middle-aged man presented with bone pain at multiple sites due to tumour-induced osteomalacia. The underlying occult phosphaturic mesenchymal tumour was identified by octreotide scan 5 years after presentation and confirmed by computed tomography. Tumour resection resulted in normalisation of blood chemistry and bone densitometry. Clinico-radiologico-pathological correlation and ultrastructural studies of the tumour threw light on the pathogenesis and pathophysiology of this rare disease.
 
Key words: Fibroblast growth factors; Osteomalacia; Soft tissue neoplasms
 
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Minimal change disease following exposure to mercury-containing skin lightening cream

ABSTRACT

Hong Kong Med J 2006;12:316-8 | Number 4, August 2006
CASE REPORT
Minimal change disease following exposure to mercury-containing skin lightening cream
HL Tang, KH Chu, YF Mak, W Lee, A Cheuk, KF Yim, KS Fung, HWH Chan, KL Tong
Division of Nephrology, Department of Medicine and Geriatrics, Princess Margaret Hospital, Laichikok, Hong Kong
 
 
A 34-year-old woman developed nephrotic syndrome after using a skin lightening cream that contained an extremely high level of mercury. Blood and urine mercury levels were elevated and a renal biopsy revealed minimal change disease. Membranous nephropathy was excluded using immunofluorescence and electron microscopy. Her proteinuria remitted 9 months after she stopped using the cosmetic cream. This is the first reported case in the English literature of proven minimal change disease secondary to mercury exposure. It is important that mercury poisoning due to cosmetic cream is considered in the differential diagnoses for any woman who presents with nephrotic syndrome.
 
Key words: Cosmetics; Glomerulonephritis; Mercury; Nephrotic syndrome; Skin/drug effects
 
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