Pain and disability in a group of Chinese elderly out-patients in Hong Kong

ABSTRACT

Hong Kong Med J 2004;10:160-5 | Number 3, June 2004
ORIGINAL ARTICLE
Pain and disability in a group of Chinese elderly out-patients in Hong Kong
DKY Miu, TY Chan, MH Chan
Department of Medicine and Geriatrics, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong
 
 
OBJECTIVE. To investigate the relationship between musculoskeletal pain and disability among a group of geriatric out-patients.
 
DESIGN. Consecutive case series.
 
SETTING. Regional hospital, Hong Kong.
 
PARTICIPANTS. Attendees at a geriatric specialist out-patient clinic from October 2002 to February 2003.
 
MAIN OUTCOME MEASURES. Pain duration, location, intensity, and frequency; use of analgesics; ability to identify the cause of pain; disability (Barthel index) and Lawton Instrumental Activities of Daily Living scale score; depressive symptoms (Geriatric Depression Scale score); and self-reported sleep quality.
 
RESULTS. Of the 749 respondents, 461 (61.5%) had experienced pain in the previous 2 weeks. Among these patients, 51.3% had received a pain-relieving drug. Compared with men, women reported a higher pain intensity (5.87 versus 5.26; P=0.001), had a lower Barthel index (96.0 versus 97.9; P=0.005), and had a lower score on the Lawton Instrumental Activities of Daily Living scale (42.19 versus 44.52; P=0.008). Multivariate logistic regression showed that the presence of pain was associated with female sex (odds ratio=2.25), poor self-rated health (0.69), and depression (1.54).
 
CONCLUSION. Pain is a common problem among the elderly population, but it is not associated with physical disability, and only half of the patients received analgesics. The study provides information for health care workers to develop strategies to better assess and manage pain problems among elderly people.
 
Key words: Aged; Disability evaluation; Musculoskeletal diseases; Pain; Sex factors
 
View this abstract indexed in MEDLINE:
 

Features predicting adverse outcomes of status epilepticus in childhood

ABSTRACT

Hong Kong Med J 2004;10:156-9 | Number 3, June 2004
ORIGINAL ARTICLE
Features predicting adverse outcomes of status epilepticus in childhood
KL Kwong, K Chang, SY Lam
Department of Paediatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
OBJECTIVE. To examine variables that might predict abnormal outcome of status epilepticus among children.
 
DESIGN. Retrospective study.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All children younger than 15 years who were admitted to the paediatric intensive care unit with status epilepticus between 1997 and 2002.
 
MAIN OUTCOME MEASURES. Neurodevelopmental outcomes.
 
RESULTS. Two of the 25 patients died, resulting in a mortality rate of 8%. No deaths were due to status epilepticus itself. No patient with febrile or idiopathic status epilepticus developed epilepsy. Neurological deterioration was observed in a quarter (six of 23) of the survivors. Symptomatic aetiology (acute or remote) and refractory status epilepticus were associated with adverse outcomes (P<0.05). Young age at status epilepticus (<12 months) and duration of status epilepticus (>60 minutes) tended to be more frequent among those who developed adverse outcome. Rectal diazepam was given before hospital arrival in only four patients.
 
CONCLUSIONS. Paediatric patients with status epilepticus who had normal neurodevelopmental status before the onset of an attack and who did not sustain an acute insult to the central nervous system or have progressive encephalopathy, had favourable outcomes. Prompt use of rectal diazepam or buccal midazolam administered by caretakers or paramedics should be encouraged.
 
Key words: Child; Infant; Status epilepticus
 
View this abstract indexed in MEDLINE:
 

Out-patient chronic pain service in Hong Kong: prospective study

ABSTRACT

Hong Kong Med J 2004;10:150-5 | Number 3, June 2004
ORIGINAL ARTICLE
Out-patient chronic pain service in Hong Kong: prospective study
PP Chen, J Chen, T Gin, M Ma, KC Fung, KH Woo, PY Wong
Division of Pain Medicine, Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To examine the profile and referral pattern of patients attending an out-patient pain management service in Hong Kong.
 
DESIGN. Prospective cross-sectional survey.
 
SETTING. Regional public hospitals, Hong Kong.
 
PATIENTS. All patients attending out-patient pain management clinics in the New Territories East public hospitals between 1 September and 31 December 2002.
 
MAIN OUTCOME MEASURES. Demographic profiles, referring specialty, pain diagnosis, pain sites, duration and severity of pain, treatment modality, litigation, compensation, and social welfare status. Data were collected using a standardised questionnaire.
 
RESULTS. Two hundred and forty-eight patients were interviewed. Most patients (70%) were middle-aged, with 21% over 60 years. Seventy-nine percent of patients were referred to the clinics either from orthopaedic surgeons (64.1%), general and other surgeons (14.9%), or general practitioners (3.6%). The median (range) duration of pain was 2.3 (0.08-26.7) years. The most common pain diagnoses were musculoskeletal back pain (46.4%) and neuropathic pain (27.8%). A total of 11.3% of the patients had two pain diagnoses, while 40.7% complained of pain in more than one location. Pain in the limbs was the most frequent complaint followed by the head, neck, and back. Approximately 38% of patients had tried four or more treatment modalities. Oral medication was the most common method (86.7%) of pain-relief treatment. More than half of the patients had also tried physiotherapy and traditional Chinese medicine. Approximately 37% of the patients were unemployed, while 31% were receiving social security subsidy. Eighty-six patients had pain associated with a work-related injury, and of these patients, 80% were involved in compensation claims.
 
CONCLUSIONS. The profile of patients referred to the pain management clinics was complex. Patients were mainly referred from specialists. The economic implication in this group of patients is likely to be significant as many patients utilised multiple treatment modalities, were unemployed and on social welfare benefits, and were involved in compensation and litigation proceedings.
 
Key words: Health care surveys; Pain; Pain clinics
 
View this abstract indexed in MEDLINE:
 

Oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study

ABSTRACT

Hong Kong Med J 2004;10:103-6 | Number 2, April 2004
ORIGINAL ARTICLE
Oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study
KW Chik, CK Li, PKS Chan, MMK Shing, V Lee, JSL Tam, PMP Yuen
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVES. To determine the role of oseltamivir prophylaxis for immunocompromised patients.
 
DESIGN. Prospective, non-blinded, non-controlled observational study.
 
SETTING. A paediatric cancer centre, Hong Kong.
 
PARTICIPANTS. Thirty-two patients, immunocompromised by chemotherapy or bone marrow transplantation during an influenza season in 2001.
 
INTERVENTION. Oral oseltamivir prophylaxis 75 mg/d for 8 weeks.
 
MAIN OUTCOME MEASURES. Laboratory-confirmed influenza infection, symptoms of influenza, drug compliance, and any side-effects from oseltamivir treatment. Laboratory monitoring included virological surveillance for influenza A and B, blood counts, and renal and liver function tests.
 
RESULTS. Patients' median age was 14.3 years (range, 6.3-23.4 years). Underlying conditions included malignancy (n=29) and other haematological diseases (n=3). No documented influenza infection according to serological tests was present throughout the study period. Five patients with symptoms of upper respiratory tract infection did not have any influenza infection detected by rapid virological assay and viral culture. For 16% of patients, the main side-effect in the study was gastro-intestinal upset.
 
CONCLUSIONS. Oral oseltamivir 75 mg once daily for 8 weeks may be useful in the prevention of influenza infection in patients immunocompromised by chemoradiotherapy; side-effects are few and acceptable.
 
Key words: Acetamides; Antiviral agents; Influenza; Neuraminidase/antagonists & inhibitors
 
View this abstract indexed in MEDLINE:
 

Precipitating factors for systolic and diastolic heart failure: a four-year follow-up of 192 patients

ABSTRACT

Hong Kong Med J 2004;10:97-101 | Number 2, April 2004
ORIGINAL ARTICLE
Precipitating factors for systolic and diastolic heart failure: a four-year follow-up of 192 patients
O Erk
Department of Emergency Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34390, Turkey
 
 
OBJECTIVES. To investigate precipitating factors for systolic and diastolic heart failure.
 
DESIGN. Prospective study.
 
PATIENTS AND METHODS. The study population consisted of 192 patients with heart failure treated for 536 episodes of acute decompensation of heart failure from 1998 to 2002. The patients were classified as having systolic or diastolic heart failure, and grouped according to aetiology and precipitating factors.
 
RESULTS. Coronary heart disease was the most common cause of systolic heart failure, whereas rheumatic heart disease was the most frequent cause of diastolic heart failure. The most important precipitating factors in systolic heart failure were infections (38%), arrhythmias (35%), and vascular causes (24%), whereas the precipitating factors in diastolic heart failure were infections (50%), arrhythmias (46%), and uncontrolled hypertension (26%). Avoidable precipitating factors in systolic and diastolic heart failure were noted in 34% and 68% of cases, respectively.
 
CONCLUSIONS. Better patient education and better follow-up of patients by physicians according to the most recent guidelines may decrease the frequency of heart failure events and consequent morbidity and mortality.
 
Key words: Heart failure, congestive; Precipitating factors; Ventricular dysfunction, left; Ventricular dysfunction, right
 
View this abstract indexed in MEDLINE:
 

Unrelated umbilical cord blood transplantation in children: experience of the Hong Kong Red Cross Blood Transfusion Service

ABSTRACT

Hong Kong Med J 2004;10:89-95 | Number 2, April 2004
ORIGINAL ARTICLE
Unrelated umbilical cord blood transplantation in children: experience of the Hong Kong Red Cross Blood Transfusion Service
CK Li, MMK Shing, KW Chik, KS Tsang, NLS Tang, PKS Chan, NK Chan, V Lee, MHL Ng, CK Lin, PMP Yuen
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To review the outcome of unrelated umbilical cord blood transplantation in children using cord blood from the Hong Kong Red Cross Blood Transfusion Service.
 
DESIGN. Retrospective study.
 
PATIENTS. Records of eight patients who received unrelated umbilical cord blood transplants between 1999 and 2003 were reviewed.
 
MAIN OUTCOME MEASURES. Engraftment of haematopoietic cells and graft-versus-host disease after transplantation.
 
RESULTS. The median age of the patients was 4.9 years (range, 1.0-9.4 years). Five patients had acute leukaemia, one had non-Hodgkin's lymphoma, one had X-linked adrenoleukodystrophy, and one had mucolipidosis. The infused umbilical cord blood units contained a median of 6.7 x 10 7 /kg nucleated cells and 4.0 x 10 /kg CD34-positive cells. Neutrophil engraftment was achieved at a median of 13 days (range, 11-19 days) and, for seven patients, platelet engraftment was achieved at a median of 39 days (range, 24-98 days). Acute graft-versus-host disease occurred in all patients (grades I to III). One of the patients died because of encephalitis; of the other seven, five developed chronic graft-versus-host disease of the skin. At a median follow-up of 2 years, the four patients with leukaemia and the one with non-Hodgkin's lymphoma remained in continuous complete remission; the patient with adrenoleukodystrophy showed stabilisation of neurological condition.
 
CONCLUSION. The Hong Kong Red Cross Blood Transfusion Service Cord Blood Bank stored cord blood units of good quality for transplantation, the outcome of which was comparable to that of bone marrow transplantation.
 
Key words: Child; Cord blood stem cell transplantation; Graft vs host disease; Leukemia
 
View this abstract indexed in MEDLINE:
 

The safety, feasibility, and acceptability of patient-controlled sedation for colonoscopy: prospective study

ABSTRACT

Hong Kong Med J 2004;10:84-8 | Number 2, April 2004
ORIGINAL ARTICLE
The safety, feasibility, and acceptability of patient-controlled sedation for colonoscopy: prospective study
DWH Lee, ACW Chan, SKH Wong, ACN Li, TS Sze, SCS Chung
Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To assess the safety, feasibility, and acceptability of patient-controlled sedation for elective day-case colonoscopy, and the factors predicting patients' unwillingness to use patient-controlled sedation for colonoscopy.
 
DESIGN. Prospective, non-randomised study.
 
SETTING. University-affiliated endoscopy centre, Hong Kong.
 
PARTICIPANTS. Five hundred patients who underwent elective day-case colonoscopy were prospectively recruited from January 2001 to June 2002.
 
INTERVENTION. Sedation for colonoscopy was a mixture of propofol and alfentanil, which was delivered by means of a patient-controlled syringe pump. Each bolus delivered 4.8 mg propofol and 12 μg alfentanil. No loading dose was used and the lockout time was set at zero.
 
MAIN OUTCOME MEASURES. Cardiopulmonary complications, dose of patient-controlled sedation used, recovery time, satisfaction score, delayed side-effects, and the willingness to use the same sedation protocol for future colonoscopy. A multiple stepwise logistic regression model was used to assess which factors might predict unwillingness to use patient-controlled sedation for colonoscopy.
 
RESULTS. The mean (standard deviation) age of patients was 53.0 (13.9) years. The mean dose of propofol consumed was 0.93 (0.69) mg/kg. Forty-three (8.6%) patients developed hypotension during the procedure. The mean satisfaction score was 7.2 (2.6). Sixteen (3.2%) patients developed delayed side-effects. The median (interquartile range) recovery time was 0 (0-5) minutes. Approximately 78% of patients were willing to use patient-controlled sedation for future colonoscopy if needed. Younger age (<50 years), female sex, a higher mean dose of sedatives used, a lower satisfaction score, and the presence of delayed side-effects were independent factors that were associated with patients" unwillingness to use patient-controlled sedation for colonoscopy.
 
CONCLUSION. The use of patient-controlled sedation for elective colonoscopy is safe, feasible, and acceptable to most patients.
 
Key words: Alfentanil; Colonoscopy; Conscious sedation; Propofo
 
View this abstract indexed in MEDLINE:
 

Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma

ABSTRACT

Hong Kong Med J 2004;10:77-83 | Number 2, April 2004
ORIGINAL ARTICLE
Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma
SY Ma, AKW Lie, WY Au, CS Chim, YL Kwong, R Liang
Division of Haematology and Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
 
 
OBJECTIVE. To present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among Chinese patients.
 
DESIGN. Retrospective study.
 
SETTING. Bone marrow transplantation unit at a university hospital, Hong Kong.
 
PATIENTS. Ten patients with multiple myeloma who received non-myeloablative allogeneic stem cell transplantation between March 2000 and October 2002.
 
INTERVENTION. Fludarabine (90 mg/m2 ) and total body irradiation (300 cGy) were given as conditioning regimens, followed by non-myeloablative allogeneic stem cell transplantation.
 
MAIN OUTCOME MEASURES. Engraftment, regimen-related toxicity, treatment-related mortality (in the first 100 days), incidence of graft-versus-host disease, chimerism, disease response, and survival rate.
 
RESULTS. All 10 patients had active disease before transplantation. The donors were eight human leukocyte antigen-matched siblings, a mismatched sibling, and a matched daughter. Satisfactory engraftment before day 21 was achieved without early treatment-related mortality. Five patients developed full donor chimerism by day 28 and three other patients had 100% donor chimerism by day 100. Acute graft-versus-host disease developed in six patients (five with grade III and one with grade IV disease), and chronic graft-versus-host disease developed in eight patients (four with extensive disease). Complete remission and partial response were achieved in three and four patients, respectively. Three patients did not respond to treatment, and one case of relapse was observed. Only one patient, who had shown a partial response, received donor lymphocyte infusion; seven patients received thalidomide for graft-versus-host disease with or without graft-versus-myeloma effect. All patients were alive after a median follow-up of 1 year.
 
CONCLUSION. Non-myeloablative allogeneic stem cell transplantation for multiple myeloma is effective, has low toxicity, and results in low treatment-related mortality. Studies of more cases with longer follow-up durations are required.
 
Key words: Multiple myeloma; Myeloablative agents; Transplantation
 
View this abstract indexed in MEDLINE:
 

Screening for vestibular schwannoma by magnetic resonance imaging: analysis of 1821 patients

ABSTRACT

Hong Kong Med J 2004;10:38-43 | Number 1, February 2004
ORIGINAL ARTICLE
Screening for vestibular schwannoma by magnetic resonance imaging: analysis of 1821 patients
TL Kwan, KW Tang, KKT Pak, JYL Cheung
Department of Radiology and Imaging, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
OBJECTIVES. To study the spectrum of diseases that can be detected by magnetic resonance imaging in patients suspected to have vestibular schwannoma (acoustic neuroma) presenting with sensorineural or mixed hearing loss, and to assess the extent of the problem of hearing loss in a screened population.
 
DESIGN. Retrospective study.
 
SETTING. Diagnostic radiology and imaging department of a regional hospital, Hong Kong.
 
PATIENTS. A total of 1821 consecutive patients from September 1999 to February 2001 with sensorineural or mixed hearing loss were referred by otolaryngologists for magnetic resonance imaging of the internal auditory canal.
 
MAIN OUTCOME MEASURES. Vestibular schwannoma; other cerebellopontine angle masses and other diseases that could account for the patients’ hearing loss.
 
RESULTS. In all, 132 (7%) patients had positive findings that could explain their hearing loss. Fifty-four (41%) of the 132 patients had vestibular schwannoma; 39 (30%) had inflammation of the middle ear and mastoids; 17 (13%) had ischaemic foci in the brainstem; 10 (8%) had other cerebellopontine angle masses or tumours; four (3%) had inner ear dysplasia; seven (5%) had vascular loop compression; and one (1%) had chronic cryptococcal meningitis. The overall incidence of vestibular schwannoma detected in this screened population was about 3%.
 
CONCLUSIONS. This study indicates that magnetic resonance imaging is an effective tool to screen for vestibular schwannoma in patients with sensorineural or mixed hearing loss. It can also be used to assess a considerable number of different pathological conditions in patients with audiovestibular disorders.
 
Key words: Hearing loss; Magnetic resonance imaging; Neuroma, acoustic
 
View this abstract indexed in MEDLINE:
 

Clinical profile and genetic basis of Brugada syndrome in the Chinese population

ABSTRACT

Hong Kong Med J 2004;10:32-7 | Number 1, February 2004
ORIGINAL ARTICLE
Clinical profile and genetic basis of Brugada syndrome in the Chinese population
NS Mok, SG Priori, C Napolitano, KK Chan, R Bloise, HW Chan, WH Fung, YS Chan, WK Chan, C Lam, NY Chan, HH Tsang
Department of Medicine and Geriatrics, Princess Margaret Hospital, Laichikok, Hong Kong
 
 
OBJECTIVE. To study the clinical profile and genetic basis of Brugada syndrome in Chinese patients.
 
DESIGN. Prospective observational study.
 
SETTING. Seven regional public hospitals, Hong Kong.
 
MAIN OUTCOME MEASURES. The clinical and follow-up data of 50 patients (47 men, 3 women; mean age, 53 years) were collected, and genetic data of 36 probands and eight family members of three genotyped probands were analysed.
 
RESULTS. Eight patients survived sudden cardiac death (group A), 12 had syncope of unknown origin but no sudden death (group B), and 30 were asymptomatic before recognition of Brugada syndrome (group C). Programmed electrical stimulation induced sustained ventricular arrhythmias in 88% (7/8), 82% (9/11), and 27% (3/11) of patients in group A, group B, and group C, respectively. New arrhythmic events occurred in 50% (4/8) of patients in group A and 17% (2/12) of patients in group B after a mean follow-up period of 30 (standard deviation, 13) months and 25 (7) months, respectively. All group C patients remained asymptomatic during a mean follow-up period of 25 (standard deviation, 11) months. Five of 36 probands and three of eight family members who underwent genetic testing were found to have a mutation in their SCN5A gene.
 
CONCLUSIONS. Chinese patients with Brugada syndrome who are symptomatic have a high likelihood of arrhythmia recurrence, whereas asymptomatic patients enjoy a good short-term prognosis. The prevalence of SCN5A mutation among probands is 14%. Thus, Chinese patients with Brugada syndrome share with their western counterparts similar clinical and genetic heterogeneity.
 
Key words: Arrhythmia; Chinese; Death, sudden, cardiac; Genetics; Recurrence
 
View this abstract indexed in MEDLINE:
 

Pages