Profiling advanced disease in an Asian clinical human immunodeficiency virus cohort: comparison of two definitions for acquired immunodeficiency syndrome

ABSTRACT

Hong Kong Med J 2010;16:199–206 | Number 3, June 2010
ORIGINAL ARTICLE
Profiling advanced disease in an Asian clinical human immunodeficiency virus cohort: comparison of two definitions for acquired immunodeficiency syndrome
SS Lee, Krystal CK Lee, Ian CT Tse, MP Lee, KH Wong, Patrick CK Li, JY Sung
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong
 
 
OBJECTIVE. To compare advanced human immunodeficiency virus disease defined immunologically and clinically by evaluating the characteristics of human immunodeficiency virus patients in Hong Kong.
 
DESIGN. Retrospective observational study.
 
SETTING. A human immunodeficiency virus cohort database established at a university and the major human immunodeficiency virus specialist services in Hong Kong.
 
PATIENTS. Patients diagnosed with acquired immunodeficiency syndrome at the study centres between 1985 and 2006 were included.
 
MAIN OUTCOME MEASURES. Comparison of advanced human immunodeficiency virus disease defined (a) clinically as World Health Organization stage IV, and (b) immunologically as a CD4 count lower than 350/microL.
 
RESULTS. Between 1985 and 2006, a total of 1317 patients, a majority of whom Chinese, were evaluated. Of these, 914 (69%) and 335 (25%) fulfilled the criteria for immunologically and clinically defined advanced disease, respectively. The mean age of the study population was 38 years and male-to-female ratio 4:1. There were two peaks in the frequency distribution of CD4 counts, one at a low count of less than 100/microL and the other between 200 and 400/microL. All except four with clinically defined advanced disease had CD4 counts lower than 350/microL on presentation. Of those with immunologically defined advanced disease, men having sex with men accounted for a lower proportion in the clinically advanced category, and Pneumocystis pneumonia was the commonest advanced disease at presentation.
 
CONCLUSIONS. Both clinical and immunological definitions provide a consistent means for assessing advanced disease, the implications of which are different. Such profiling has been made possible through the operation of a standardised cohort database, which is useful in (1) enhancing human immunodeficiency virus epidemiology studies, and (2) evaluating the performance of public health services.
 
Key words: Acquired immunodeficiency syndrome; CD4-positive T-lymphocytes; HIV infections; leukocyte count; Penicillium
 
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The epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in Hong Kong

ABSTRACT

Hong Kong Med J 2010;16:192–8 | Number 3, June 2010
ORIGINAL ARTICLE
The epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in Hong Kong
CK Chan, F Alvarez Bognar, KH Wong, CC Leung, CM Tam, Kenny CW Chan, CF Ho, WK Chan, Ida KY Mak
Tuberculosis and Chest Service, Public Health Services Branch, Centre for Health Protection, Department of Health, Hong Kong
 
 
OBJECTIVE. To evaluate the epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in Hong Kong.
 
DESIGN. Retrospective study.
 
SETTING. Tuberculosis and Chest Service and Special Preventive Programme, Public Health Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region.
 
PATIENTS. Cases reported to the TB/HIV Registry jointly kept by the Tuberculosis and Chest Service and Special Preventive Programme from 1996 to 2006 were reviewed. The Registry includes cases of human immunodeficiency virus-associated tuberculosis diagnosed in the two services, and cases referred from regional hospitals under the Hong Kong Hospital Authority and the private sector.
 
RESULTS. Tuberculosis has become an increasingly important acquired immunodeficiency syndrome-defining illness in Hong Kong, and overtook Pneumocystis jiroveci pneumonia for the first time as the most common primary acquired immunodeficiency syndrome-defining illness in 2005 (accounting for 39% and 31% of all such illnesses, respectively in that year). The presentation of human immunodeficiency virus-associated tuberculosis is often atypical. In these patients moreover, there was a slightly higher rate of multidrug-resistant tuberculosis (2%) than in the general population (range, 0.7-1.5%).
 
CONCLUSIONS. Programmes for the provider-initiated human immunodeficiency virus testing policy to reduce diagnostic delays should continue and be enhanced. Continual surveillance of both conditions is imperative, especially in view of a possible link between human immunodeficiency virus and multidrug-resistant tuberculosis.
 
Key words: AIDS-related opportunistic infections; Anti-HIV agents; HIV infections; Tuberculosis, multidrug-resistant
 
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Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience

ABSTRACT

Hong Kong Med J 2010;16:186–91 | Number 3, June 2010
ORIGINAL ARTICLE
Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience
CK Lo, CH Yu, CC Ma, KM Ko, Samuel CL Leung
Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong
 
 
OBJECTIVE. To report the surgical experience in the management of patients with synchronous primary lung cancer and solitary brain metastasis.
 
DESIGN. Retrospective cohort study.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. Seventeen patients with synchronous primary lung cancer and solitary brain metastasis were treated by pulmonary resection and neurosurgical intervention between 1994 and 2007.
 
RESULTS. Median patient survival was 52 months (95% confidence interval, 9-95 months) and the 5-year survival was 27%. The univariate analysis yielded no significant prognostic factor. Four out of six patients who had lymph node metastases developed tumour recurrence.
 
CONCLUSION. In view of encouraging survival results, aggressive therapy including pulmonary resection and neurosurgical intervention should be recommended for patients with synchronous presentation with primary lung cancer and solitary brain metastasis.
 
Key words: Brain neoplasms; Carcinoma, non-smallcell lung; Lung neoplasms; Survival rate
 
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Association of sleep hygiene-related factors and sleep quality among university students in Hong Kong

ABSTRACT

Hong Kong Med J 2010;16:180–5 | Number 3, June 2010
ORIGINAL ARTICLE
Association of sleep hygiene-related factors and sleep quality among university students in Hong Kong
Lorna KP Suen, Wilson WS Tam, KL Hon
The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
OBJECTIVE. To examine whether sleep hygiene-related factors are associated with sleep quality among university students.
 
DESIGN. Cross-sectional survey.
 
SETTING. A university in Hong Kong.
 
PARTICIPANTS. Full-time university students recruited by convenience sampling.
 
MAIN OUTCOME MEASURES. Responses to a sleep questionnaire containing the Pittsburgh Sleep Quality Index and obtaining sleep hygiene knowledge and practice, as well as knowledge on caffeine were used for data collection.
 
RESULTS. Regression analysis with stepwise selection procedure revealed that sleep hygiene practice was significantly associated with the Pittsburgh Sleep Quality Index score after adjusting for age, gender, year of study, and type of residence (b= -0.08, P<0.001).
 
CONCLUSIONS. Our study's results indicated that sleep hygiene practice was significantly associated with sleep quality. Appropriate measures and sleep hygiene education need to be emphasised among university students in order to increase their awareness on the importance of adopting healthy sleep hygiene practices.
 
Key words: Questionnaires; Sleep; Sleep deprivation; Sleep disorders; Students
 
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Human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy Chinese women from Hong Kong

ABSTRACT

Hong Kong Med J 2010;16:171–9 | Number 3, June 2010
ORIGINAL ARTICLE
Human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy Chinese women from Hong Kong
Hextan YS Ngan, Annie NY Cheung, KF Tam, Karen KL Chan, HW Tang, D Bi, Dominique Descamps, Hans L Bock
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
 
 
OBJECTIVE. To assess the immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in Chinese women aged 18 to 35 years enrolled from Hong Kong.
 
DESIGN. Double-blind, randomised controlled trial with vaccine and placebo groups.
 
SETTING. Single-centre study in Hong Kong.
 
PARTICIPANTS. Three hundred women enrolled (150 per group) between March 2006 and June 2007.
 
INTERVENTIONS. Subjects received three doses of human papillomavirus-16/18 vaccine or placebo (aluminium hydroxide), administered intramuscularly at 0, 1, and 6 months.
 
MAIN OUTCOME MEASURES. Human papillomavirus-16/18 seroconversion rates and geometric mean titres at month 7 (in human papillomavirus-16/18 recipients); reactogenicity and safety (in all subjects).
 
RESULTS. A total of 294 women completed the study (148 in the vaccine group, 146 in placebo group). All initially seronegative subjects in the vaccine group had seroconverted for human papillomavirus-16/18 antibodies by month 7. Anti-human papillomavirus-16 and anti-human papillomavirus-18 antibody geometric mean titres were 10 422 (95% confidence interval, 8730-12 442) EL.U/mL and 4649 (3975-5437) EL.U/mL, respectively. High compliance (99% in both groups) was observed for the three-vaccination course. The frequencies of local injection site reactions were higher in the vaccine than placebo group; pain being the most common symptom in both groups. Regarding solicited symptoms, fatigue and myalgia were the most frequent in both groups. Five serious adverse events (four in vaccine group, one in placebo group) were reported, but all were considered unrelated to the vaccinations.
 
CONCLUSION. The human papillomavirus-16/18 AS04-adjuvanted vaccine was highly immunogenic, safe, and generally well tolerated in Chinese women from Hong Kong.
 
Key words: Adjuvants, immunologic; Cervical intraepithelial neoplasia; Human papillomavirus 16; Human papillomavirus 18; Uterine cervical neoplasms
 
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Comparing the effectiveness of video self-instruction versus traditional classroom instruction targeted at cardiopulmonary resuscitation skills for laypersons: a prospective randomised controlled trial

ABSTRACT

Hong Kong Med J 2010;16:165–70 | Number 3, June 2010
ORIGINAL ARTICLE
Comparing the effectiveness of video self-instruction versus traditional classroom instruction targeted at cardiopulmonary resuscitation skills for laypersons: a prospective randomised controlled trial
CH Chung, Axel YC Siu, Lucia LK Po, CY Lam, Peter CY Wong
Hong Kong St John Ambulance, St John Tower, 2 Macdonnell Road, Hong Kong
 
 
OBJECTIVE. To determine whether in the local lay Hong Kong population, video self-instruction about cardiopulmonary resuscitation has comparable results to traditional classroom instructions.
 
DESIGN. Prospective randomised single-blind controlled trial.
 
SETTING. A first-aid training organisation in Hong Kong.
 
PARTICIPANTS. Cantonese applicants for cardiopulmonary resuscitation courses aged between 18 and 70 years were recruited into the study. They were randomised into two groups. Those selected for self-learning were given a kit (consisting of a mini-manikin, a video compact disc, and an instruction manual) and sent home. The other group underwent usual classroom training. Both groups were examined together; the examiners remained blinded to the background training of the subjects. Those who passed were asked to come back for re-examination after 1 year.
 
MAIN OUTCOME MEASURES. The examination passing rates initially and after 1 year.
 
RESULTS. During a 1-year period between 1 April 2007 to 31 March 2008, 256 subjects were recruited into this study, 124 for self-learning and 132 for classroom training. The age range was 18 to 62 (mean, 39; standard deviation, 10) years. There was no significant difference in passing rate between the two groups at the initial examination or at the re-examination after 1 year. Notably, 28 (23%) of the participants of the self-learning group taught cardiopulmonary resuscitation to relatives and friends.
 
CONCLUSION. Video self-learning resulted in cardiopulmonary resuscitation performance as good as traditional classroom training.
 
Key words: Education; Heart arrest; Learning; Public sector; Teaching
 
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Endoscopic carpal tunnel release: experience of surgical outcome in a Chinese population

ABSTRACT

Hong Kong Med J 2010;16:126–31 | Number 2, April 2010
ORIGINAL ARTICLE
Endoscopic carpal tunnel release: experience of surgical outcome in a Chinese population
CH Lam, SH Yeung, TC Wong
Department of Orthopaedics and Traumatology, Tseung Kwan O Hospital, Hong Kong
 
 
OBJECTIVE. To review the outcomes of endoscopic carpal tunnel release in a Hong Kong public hospital and identify any predictive factors.
 
DESIGN. Retrospective study.
 
SETTING. Regional hospital with a hand surgery service, Hong Kong.
 
PATIENTS. Between January 2001 and December 2007, records of 145 patients (160 carpal tunnel syndromes) having endoscopic release were reviewed. Five major symptom domains (pain, numbness, nocturnal awakening, weakness, and clumsiness) before and after the operation were scrutinised. Functional status was assessed by grading key pinch and hand grip, as well as complications.
 
INTERVENTION. Endoscopic carpal tunnel release using the modified Chow's extrabursal technique under intravenous anaesthesia.
 
RESULTS. After the 160 procedures performed, 124 (78%) and 132 (83%) of them revealed improvement in terms of numbness and nocturnal awakening, respectively. Also, there were significant improvements in terms of average functional grading of pinch power and grip power. No serious complications due to the surgery were encountered.
 
CONCLUSIONS. Experience using the Chow's two-portal endoscopic technique for the treatment of carpal tunnel syndrome in the Chinese population was encouraging. It was a safe and effective method for treating carpal tunnel syndrome. We advocate endoscopic surgical intervention for patients with refractory relief of symptoms following conservative management.
 
Key words: Carpal tunnel syndrome; Endoscopy; Treatment outcome
 
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Endoscopic ultrasonography-guided fine-needle aspiration in the management of mediastinal diseases: local experience of a novel investigation

ABSTRACT

Hong Kong Med J 2010;16:121–5 | Number 2, April 2010
ORIGINAL ARTICLE
Endoscopic ultrasonography-guided fine-needle aspiration in the management of mediastinal diseases: local experience of a novel investigation
YT Lee, Larry H Lai, Joseph JY Sung, Fanny WS Ko, David SC Hui
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To study the efficacy and safety of endoscopic ultrasonography–guided fine-needle aspiration in the management of mediastinal diseases in Hong Kong.
 
DESIGN. Retrospective review of prospectively collected data.
 
SETTING. University teaching hospital, Hong Kong.
 
PATIENTS. A total of 125 consecutive patients with various mediastinal and pulmonary lesions that underwent trans-oesophageal endoscopic ultrasonography–guided fine-needle aspiration from July 1998 to June 2007.
 
MAIN OUTCOME MEASURES. The diagnostic accuracy and safety of the procedure and its influence in patient management.
 
RESULTS. Malignancy was confirmed in 62 (50%) of the patients and excluded in 42 (34%). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of endoscopic ultrasonography–guided fine-needle aspiration in diagnosing mediastinal malignancies were 75% (95% confidence interval, 64-83%), 100% (90-100%), 100% (93-100%), 67% (54-78%), and 83%, respectively. Eighty-six (69%) of the patients had their initial plan of invasive investigations changed. Only one (0.8%) patient developed a septic complication in a mediastinal cyst after puncturing, and was treated surgically.
 
CONCLUSIONS. Trans-oesophageal endoscopic ultrasonography–guided fineneedle aspiration is a minimally invasive, effective, and safe method of diagnosing malignant mediastinal disease. It may reduce the need for other invasive investigations.
 
Key words: Biopsy, needle; Carcinoma, non–small-cell lung; Endosonography; Lung neoplasms; Mediastinum
 
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Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients

ABSTRACT

Hong Kong Med J 2010;16:116–20 | Number 2, April 2010
ORIGINAL ARTICLE
Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients
Wendy F Bower, Lawrence Jin, Malcolm J Underwood, YH Lam, Paul BS Lai
Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVES. To test the hypothesis that blood transfusion alone was a significant risk factor for in-hospital morbidity in non-cardiac patients.
 
DESIGN. Propensity analysis.
 
SETTING. University teaching hospital, Hong Kong.
 
PATIENTS. Consecutive non-cardiac patients seen in our department from 2006 to early 2009 who underwent a major procedure under general or spinal anaesthesia were included. Propensity analysis was performed to neutralise the confounding effects of preoperative variables and identify the true effects of transfusions on surgical outcomes.
 
MAIN OUTCOME MEASURES. Receipt of intra-operative and postoperative blood transfusion was established and the difference in proportions between patients who did and did not receive donor blood tested for mortality, overall morbidity, individual complications, and number of adverse events.
 
RESULTS. Transfused patients were significantly older and sicker, more likely to be male, to have lower haemoglobin values and undergo longer and more emergency surgical procedures than those not receiving a transfusion. Blood transfusion was predictive of length of postoperative hospital stay and number of complications before discharge. The amount of transfused blood was predictive of in-hospital mortality, with an odds ratio of 1.4 for each unit of blood received. The risk of a surgical wound infection was almost doubled when the patient had received a blood transfusion.
 
CONCLUSION. After controlling for the factors associated with an increased likelihood for receiving a blood transfusion, the actual transfusion was predictive of a slower and more eventful postoperative recovery with associated costs to both the patient and health services.
 
Key words: Blood component transfusion; General surgery; Infection; Morbidity; Risk factors
 
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The concepts of family doctor and factors affecting choice of family doctors among Hong Kong people

ABSTRACT

Hong Kong Med J 2010;16:106–15 | Number 2, April 2010
ORIGINAL ARTICLE
The concepts of family doctor and factors affecting choice of family doctors among Hong Kong people
Albert Lee, Sam Siu, Augustine Lam, Clement Tsang, Kenny Kung, Philip KT Li
School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong
 
 
OBJECTIVES. To identify concepts including misconceptions among the community members regarding family doctors, and determine factors affecting decisions on which doctor to consult in different clinical scenarios.
 
DESIGN. Household telephone survey conducted between 4 and 13 September 2006.
 
SETTING. Hong Kong community.
 
PARTICIPANTS. Cantonese-speaking Hong Kong residents aged 18 years or more were targeted. Randomly selected participants were asked to complete a questionnaire, which was designed based on a literature search and subsequent focus group discussions.
 
RESULTS. Among the 1811 households with eligible subjects to survey, 1204 completed the questionnaire (response rate, 67%). More than 85% considered a family doctor to be the first doctor they wanted to see even if it was inconvenient. "Clearly knowing my physical conditions", "fast-acting and effective treatment", and "doctor with friendly and sincere attitude" were the three most important factors influencing the choice of a family doctor. When affected by flu-like symptoms, 65% would go to a private clinic, 20% to a general out-patient clinic, 6% to a designated clinic with staff approved by their respective medical insurance/ medical benefit scheme, and 5% to a private hospital outpatient clinic. Among the latter two groups, 65% consulted the same doctor every time when they felt sick. More than 50% of those willing to have regular follow-up by a family doctor for hypertension and diabetes paid more than HK$300 per month. Approximately 64% might consider having regular follow-up at a general out-patient clinic by a nurse specialist.
 
CONCLUSION. Hong Kong inhabitants already have their own ideas regarding how to care for their own health, and what kind of family doctors they prefer. This survey should help both doctors and health care policy makers to realign their current thinking, and thus provide a platform for the development of a primary care model unique to Hong Kong.
 
Key words: Clinical competence; Patient satisfaction; Physician-patient relations; Physicians, family; Quality indicators, health care
 
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