Advance directives and life-sustaining treatment: attitudes of Hong Kong Chinese elders with chronic disease

ABSTRACT

Hong Kong Med J 2011;17:105–11 | Number 2, April 2011
ORIGINAL ARTICLE
Advance directives and life-sustaining treatment: attitudes of Hong Kong Chinese elders with chronic disease
Fion H Ting, Esther Mok
Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
 
 
OBJECTIVE. To examine the attitudes of Hong Kong Chinese elders with chronic disease with regard to advance directives and life-sustaining treatment.
 
DESIGN. Cross-sectional questionnaire survey.
 
SETTING. Medical unit of a regional teaching hospital in Hong Kong.
 
PARTICIPANTS. In-patients aged 60 years or above with chronic disease.
 
MAIN OUTCOME MEASURES. Demographic profiles and attitudes towards advance directives and life-sustaining treatment.
 
RESULTS. A total of 219 elderly patients completed the questionnaire. Their mean age was 73 (standard deviation, 8) years; 133 (61%) were female. The majority had neither heard about advance directives (81%), nor discussed the issue with others (73%) before participating in this study. After they were informed of the concept of advance directives, about half (49%) said they would consider using it if it is legislated in Hong Kong. The respondents generally supported the withholding or withdrawing of life-sustaining treatment in medically futile situations. In all, 55% of them believed that the patient alone should make the decision on withholding or withdrawing life-sustaining treatment, if competent to do so. If the patient became not competent, 44% believed that the individual's family alone should make such a decision.
 
CONCLUSION. The fact that most of the respondents had never heard about advance directives or discussed the concept with others points to a lack of knowledge and to the necessity to step up public education about such issues.
 
Key words: Advance directives; Chronic disease; Decision making; Ethics, medical; Life support care
 
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Factors affecting mortality in Hong Kong patients with upper limb necrotising fasciitis

ABSTRACT

Hong Kong Med J 2011;17:96–104 | Number 2, April 2011
ORIGINAL ARTICLE
Factors affecting mortality in Hong Kong patients with upper limb necrotising fasciitis
Yeung YK, Ho ST, Yen CH, Ho PC, Tse WL, Lau YK, Choi KY, Choi ST, Lam MM, Cheng SH, Wong TC; The Hong Kong Society for Surgery of the Hand
Department of Orthopaedics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong
 
 
OBJECTIVE. To identify predictive factors for mortality of patients with upper limb necrotising fasciitis.
 
DESIGN. Retrospective study.
 
SETTING. Six hospitals in Hong Kong.
 
PATIENTS. Clinical records of 29 patients treated in the hospitals were traced and analysed.
 
MAIN OUTCOME MEASURES. Possible predictive factors for mortality as evaluated by application of Fisher's test.
 
RESULTS. Overall mortality was 28%. Digital infections conferred a lower mortality, but progressive necrosis necessitated amputation. Vibrio vulnificus was the commonest organism identified in association with marine injury and in patients with cirrhosis. Prognostic indicators with decreasing significance include deranged renal and liver function, thrombocytopaenia, proximal involvement (elbow or above) initially, and presence of hypotension upon admission.
 
CONCLUSION. With a P value of less than 0.05, deranged renal and liver function, thrombocytopaenia, initial proximal involvement, and hypotension on admission were predictors of mortality in necrotising fasciitis affecting the upper limbs. The ALERTS (Abnormal Liver function, Extent of infection, Renal impairment, Thrombocytopenia, and Shock) score with a cutoff of 3 appeared to predict mortality.
 
Key words: Bacterial infections; Debridement; Fasciitis, necrotizing; Upper extremity; Vibrio vulnificus
 
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A population-based analysis of incidence, mortality, and stage-specific survival of cervical cancer patients in Hong Kong: 1997-2006

ABSTRACT

Hong Kong Med J 2011;17:89–95 | Number 2, April 2011
ORIGINAL ARTICLE
A population-based analysis of incidence, mortality, and stage-specific survival of cervical cancer patients in Hong Kong: 1997-2006
FY Cheung, Oscar WK Mang, Stephen CK Law
Hong Kong Cancer Registry, R Block, 1/F, Queen Elizabeth Hospital, Kowloon, Hong Kong
 
 
OBJECTIVES. To determine the trends in incidence and mortality of cervical cancer patients diagnosed during 1997 to 2006, and to describe stage-specific survival using population-based cancer registry data.
 
DESIGN. Retrospective, population-based study.
 
SETTING. Hong Kong.
 
PATIENTS. All patients diagnosed with cervical cancer between 1997 and 2006. Patients eligible for survival analysis were followed up till 31 December 2007.
 
MAIN OUTCOME MEASURES. Age-standardised incidence and mortality rates and average annual percent changes in these parameters were calculated using the Poisson regression model. Survival was expressed as relative survival rate using a period approach. Hazard ratios of mortality including 95% confidence intervals for certain variables were estimated using the Cox proportional hazards model.
 
RESULTS. During the 10-year period of the study, overall annual incidence and mortality rates decreased by 4.2% and 6.0%, respectively. Significant rates of reduction were observed in all age-groups except those younger than 45 years. The reduction in incidence of squamous cell carcinoma (3.6% annually) was less than that of adenocarcinoma (5.2%) and other histological types (6.8%). In all, 3807 (86.4%) of the patients were included in survival analysis. The overall 5-year relative survival rate was 71.3% (95% confidence interval, 69.5-73.1%), while the values for stages I, II, III, and IV were 90.9%, 71.0%, 41.7%, and 7.8%, respectively. Age, stage, and histology were independent prognostic factors. Survival of stage IA patients was as good as that of the general population.
 
CONCLUSIONS. As in other industrialised countries, the incidence and mortality rate of cervical cancer were decreasing. Stage-specific population-based cancer survival was available for the first time, and was useful as an indicator of cancer control. Collaboration between public and private sectors to further improve the follow-up data could provide more comprehensive surveillance information.
 
Key words: Epidemiologic studies; Incidence; Prevalence; Survival analysis; Uterine cervical neoplasms
 
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Laparoscopic sacrocolpopexy for the treatment of vaginal vault prolapse: with or without robotic assistance

ABSTRACT

Hong Kong Med J 2011;17:54–60 | Number 1, February 2011
ORIGINAL ARTICLE
Laparoscopic sacrocolpopexy for the treatment of vaginal vault prolapse: with or without robotic assistance
Symphorosa SC Chan, Selina MW Pang, TH Cheung, Rachel YK Cheung, Tony KH Chung
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To assess perioperative and medium-term outcome after laparoscopic sacrocolpopexy with or without robotic assistance for vaginal vault prolapse in a Hong Kong tertiary centre.
 
DESIGN. Retrospective study.
 
SETTING. An urogynaecology unit in Hong Kong.
 
PATIENTS. All women who underwent laparoscopic sacrocolpopexy with or without robotic assistance for vaginal vault prolapse from March 2005 to May 2010.
 
MAIN OUTCOME MEASURES. The perioperative and medium-term outcomes.
 
RESULTS. A total of 36 women underwent the operation during the study period. The mean operating time was 205 minutes, mean blood loss was 144 mL. The median hospital stay was 4 days. Two women required early re-operation but recovered fully. In all, 35 women were followed up for 29 (standard deviation, 19) months. Three of them (9%) had a recurrence of stage II prolapse, but there was statistically significant improvement in the pelvic organ prolapse quantification assessment for all three compartments of the vagina, and the length of vagina was well preserved. There were no mesh exposure or erosions. The overall objective cure rate of 91% (32/35) was high, and 91% (32/35) were satisfied with the operative outcome. Stress incontinence and voiding difficulty were significantly reduced.
 
CONCLUSION. Laparoscopic sacrocolpopexy for vaginal vault prolapse is safe, although complications arising from concomitant surgery should not be neglected. High rates of objective cures and patient satisfaction were achieved. There were no mesh exposure or erosions. Laparoscopic sacrocolpopexy should be considered an option for women with vaginal vault prolapse.
 
Key words: Gynecologic surgical procedures; Laparoscopy; Robotics; Pelvic organ prolapse
 
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Family medicine training in Hong Kong: similarities and differences between family and non-family doctors

ABSTRACT

Hong Kong Med J 2011;17:47–53 | Number 1, February 2011
ORIGINAL ARTICLE
Family medicine training in Hong Kong: similarities and differences between family and non-family doctors
YT Wun, TP Lam, KF Lam, Donald KT Li, KC Yip
Department of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong
 
 
OBJECTIVE. To study the local medical profession’s opinions on the training requirements for the specialty of family medicine. This was to serve as a reference for future planning of the health care system.
 
DESIGN. Cross-sectional study.
 
PARTICIPANTS AND SETTING. All registered doctors in Hong Kong.
 
MAIN OUTCOME MEASURES. Doctors’ ratings on the importance of vocational training, professional assessment, job nature, and experience to become suitably qualified as a family doctor, and their opinions on the length of necessary vocational training.
 
RESULTS. A total of 2310 doctors (23% of doctors in the local register) responded. Professional assessment was mostly agreed as a qualification, followed by vocational training, clinical experience, and job nature. Over 70% agreed on a training period of 4 years or less. Non-family doctors were more likely to opt for professional assessment as the qualification and also opt for a longer training period.
 
CONCLUSION. Vocational training was considered important as a qualification for the specialty of family medicine. The length of training was mostly agreed to be 4 years or less, not the 6 years currently required by the Hong Kong Academy of Medicine. The vocational training programme for family medicine might require re-examination.
 
Key words: Clinical competence; Family practice; Health services; Primary health care; Quality of health care
 
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Cross-clade immunogenicity and safety of an AS03A-adjuvanted prepandemic H5N1 influenza vaccine in Hong Kong

ABSTRACT

Hong Kong Med J 2011;17:39–46 | Number 1, February 2011
ORIGINAL ARTICLE
Cross-clade immunogenicity and safety of an AS03A-adjuvanted prepandemic H5N1 influenza vaccine in Hong Kong
Daniel WS Chu, Alfred SK Kwong, Wendy WS Tsui, Jenny HL Wang, Charles KH Ngai, Peter KT Wan, Gary Ong, HW Tang, François Roman, Mamadou Dramé, Hans L Bock
Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
 
 
OBJECTIVE. To present Hong Kong–specific data from a large Asian population (also involving Thailand, Singapore, and Taiwan) on safety and manufacturing consistency across four AS03A-adjuvanted H5N1 vaccine formulations in terms of immune response against the A/Vietnam/1194/2004 strain. Immunogenicity against the heterologous A/Indonesia/05/2005 strain was also assessed. NCT Number: 00449670.
 
DESIGN. Prospective, observer-blind study.
 
SETTING. Out-patient clinic of a tertiary hospital in Hong Kong.
 
PARTICIPANTS. A total of 360 subjects aged 18 to 60 years were randomised into six groups to receive two doses (21 days apart) of the study vaccine. Interventions One of the four adjuvanted formulations (3.75 _g H5N1 haemagglutinin [HA]+AS03A) of the vaccine (H5N1-AS03A) or one of the two non-adjuvanted (3.75 _g H5N1 [HA]) formulations of the vaccine (H5N1-DIL).
 
MAIN OUTCOME MEASURES. Blood samples collected before vaccination and 21 days after each vaccine dose were analysed using haemagglutinationinhibition and neutralisation assays. Solicited, unsolicited, and serious adverse events were recorded.
 
RESULTS. Manufacturing consistency across all four vaccine formulations was demonstrated. After two doses, the AS03A-adjuvanted prepandemic influenza vaccine demonstrated high seroprotection rates against the A/Vietnam/1194/2004 strain (95.8%) and good immunogenicity against the heterologous A/Indonesia/05/2005 strain (45.7%), as compared to the non-adjuvanted vaccine (4.6% and 1.5%, respectively). The seroconversion rates induced by the adjuvanted formulations in terms of viral neutralising antibodies against the two strains were much higher than those induced by the non-adjuvanted formulations. There were no safety concerns for any of the adjuvanted vaccine formulations.
 
CONCLUSIONS. The AS03A-adjuvanted H5N1 prepandemic influenza vaccine demonstrated good immunogenicity and an acceptable safety profile in Hong Kong.
 
Key words: Adjuvants, immunologic; Disease outbreaks; Influenza A virus, H5N1 subtype; Influenza vaccines; Influenza, human
 
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Robot-assisted versus standard laparoscopic partial nephrectomy: comparison of perioperative outcomes from a single institution

ABSTRACT

Hong Kong Med J 2011;17:33–8 | Number 1, February 2011
ORIGINAL ARTICLE
Robot-assisted versus standard laparoscopic partial nephrectomy: comparison of perioperative outcomes from a single institution
CL Cho, KL Ho, Simon SM Chu, PC Tam
Division of Urology, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong
 
 
OBJECTIVE. To evaluate the perioperative outcomes of robot-assisted laparoscopic partial nephrectomy and standard laparoscopic partial nephrectomy in a teaching hospital.
 
DESIGN. Retrospective study.
 
SETTING. Division of Urology, Department of Surgery, Queen Mary and Tung Wah hospitals, Hong Kong.
 
PATIENTS. The first 10 consecutive patients who had robot-assisted laparoscopic partial nephrectomy for renal tumours between January 2008 and September 2009 with prospective data collection were evaluated. Their outcomes were compared with the last 10 consecutive patients in our database, who had standard laparoscopic partial nephrectomy between November 2004 and October 2007.
 
MAIN OUTCOME MEASURES. Demographics, tumour characteristics, perioperative outcomes, renal function, and pathological outcomes.
 
RESULTS. There were no differences between the groups with regard to age (63 vs 56 years; P=0.313) and tumour size (2.7 vs 2.8 cm; P=0.895). No significant difference was found between the two groups with respect to the operating room time (376 vs 361 min; P=0.722), estimated blood loss (329 vs 328 mL; P=0.994), and length of hospital stay (7 vs 14 days; P=0.213). A statistically significant shorter mean warm ischaemic time for the robotassisted group was noted (31 vs 40 minutes; P=0.032). Respective renal functional outcomes as shown by the difference between day 0 and day 60 serum creatinine levels were comparable (+10 vs +7 mmol/L; P=0.605). In both groups, there were no intra-operative complications or instances of surgical margin tumour involvement. Three patients endured postoperative complications in the standard laparoscopic group (a perinephric haematoma, urine leakage, and lymph leakage) compared with one in the robot-assisted group (a perinephric haematoma). These complications all resolved with conservative treatment.
 
CONCLUSIONS. Robot-assisted laparoscopic partial nephrectomy is a technically feasible alternative to standard laparoscopic partial nephrectomy, and provides comparable results. Robot-assisted laparoscopic partial nephrectomy appears to offer the advantage of decreased warm ischaemic time. Longer follow-up is required to assess renal function and oncological outcomes. Further experience and randomised trials are necessary to compare robot-assisted with standard laparoscopic partial nephrectomy.
 
Key words: Kidney neoplasms; Laparoscopy; Nephrectomy; Robotics; Suture techniques
 
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Clinical outcome of open and laparoscopic surgery in Dukes' B and C rectal cancer: experience from a regional hospital in Hong Kong

ABSTRACT

Hong Kong Med J 2011;17:26–32 | Number 1, February 2011
ORIGINAL ARTICLE
Clinical outcome of open and laparoscopic surgery in Dukes' B and C rectal cancer: experience from a regional hospital in Hong Kong
Weida Day, Patrick YY Lau, KM Li, SY Kwok, Andrew WC Yip
Department of Surgery, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong
 
 
OBJECTIVE. To compare the long-term outcome of open and laparoscopic surgery for Dukes' B and C rectal cancer in a regional hospital in Hong Kong.
 
DESIGN. Retrospective study.
 
SETTING. A regional hospital in Hong Kong.
 
MAIN OUTCOME MEASURES. Survival and local recurrence rates.
 
PATIENTS. Patients with Dukes' B and C rectal cancers underwent elective curative open or laparoscopic surgery during the period December 2000 to December 2006.
 
RESULTS. A total of 222 patients (open surgery, n=133; laparoscopic surgery, n=89) were assessed. The overall 3- and 5-year survival rates for all patients were 72% and 58%, respectively. Local recurrence rates were similar in both groups. Laparoscopic group had better overall survival (P=0.014), however. The overall 3-year survival rates were 79% and 68% in the laparoscopic and open groups, respectively. The corresponding 5-year rates were 75% and 52%. Multivariate analysis also demonstrated that laparoscopic surgery was a significant independent factor for better survival. Chemotherapy, local recurrence, lymph node metastasis, and poorly differentiated tumour were significantly associated with survival.
 
CONCLUSION. Laparoscopic surgery for Dukes' B and C rectal cancer was associated with more favourable survival than with open surgery.
 
Key words: Disease-free survival; Laparoscopy; Neoplasm recurrence, local; Rectal neoplasms; Treatment outcome
 
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Total knee arthroplasty for primary knee osteoarthritis: changing pattern over the past 10 years

ABSTRACT

Hong Kong Med J 2011;17:20–5 | Number 1, February 2011
ORIGINAL ARTICLE
Total knee arthroplasty for primary knee osteoarthritis: changing pattern over the past 10 years
CH Yan, KY Chiu, FY Ng
Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
 
 
OBJECTIVE. To review the epidemiology of total knee arthroplasty for primary osteoarthritis and the change of patient characteristics over the last decade.
 
DESIGN. Retrospective review.
 
SETTING. A tertiary referral centre for joint replacement surgery in a teaching hospital in Hong Kong.
 
PATIENTS. All patients who underwent primary total knee arthroplasty for primary knee osteoarthritis from January 2000 to December 2009.
 
RESULTS. In all, 1157 total knee arthroplasties (589 left and 568 right) were performed on 588 females and 162 males. The annual number of total knee arthroplasties increased from 91 in 2000 to 181 in 2009. The annual number of patients increased from 58 (46 female, 12 male) in 2000 to 159 (117 female, 42 male) in 2009. When compared yearly results, there were no significant changes in the preoperative Knee Society Knee Score, Knee Society Functional Assessment, and passive range of motion of these patients. However, there was a significant decreasing trend with regard to lower limb mechanical axis mal-alignment, from 15.1º deviation from the neutral axis in 2000, to 14.8º deviation in 2004, and then 12.9º deviation in 2009 (mostly varus deformity). There was no difference between left knees and right knees, and between females and males. The mean age of the patients did not show significant change over the past decade, but the number and proportion of patients over 80 years old showed an increase from 4.8% (2000 to 2004) to 13.8% (2005 to 2009). On the other hand, the number and proportion of patients under the age of 60 years did not change.
 
CONCLUSIONS. There was an increasing trend towards total knee arthroplasties, both in terms of number of operations and patients. The number of younger patients having total knee arthroplasty did not increase over the last 10 years, whereas the number of those older than 80 years increased significantly over that period.
 
Key words: Arthroplasty, replacement, knee; Hong Kong; Knee joint; Osteoarthritis, knee; Registries
 
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Hepatocarcinogenesis of regenerative and dysplastic nodules in Chinese patients

ABSTRACT

Hong Kong Med J 2011;17:11–9 | Number 1, February 2011
ORIGINAL ARTICLE
Hepatocarcinogenesis of regenerative and dysplastic nodules in Chinese patients
CH Ng, SW Chan, WK Lee, Lawrence Lai, KH Lok, KK Li, SH Luk, ML Szeto
Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
OBJECTIVES. To determine the development rate of hepatocellular carcinoma and survival of patients diagnosed to have regenerative, and low-grade and high-grade dysplastic liver nodules.
 
DESIGN. Retrospective descriptive study.
 
SETTING. Acute public hospital, Hong Kong.
 
PATIENTS. Patients with non-malignant liver nodules confirmed by imagingguided liver biopsy between January 1997 and December 2008.
 
MAIN OUTCOME MEASURES. Rates of hepatocellular carcinoma development and survival.
 
RESULTS. A total of 147 patients with non-malignant liver nodules were followed up over a median duration of 29 months. The initial histological diagnosis included regenerative nodules (n=74), low-grade dysplastic nodules (n=34), and high-grade dysplastic nodules (n=39). The respective cumulative hepatocellular carcinoma development rate during the first, second, third, and fourth year were 3%, 5%, 9% and 12% for simple regenerative nodules, 29%, 35%, 38% and 44% for low-grade dysplastic nodules, and 38%, 41%, 51% and 51% for high-grade dysplastic nodules. The hepatocellular carcinoma development rate was highest in those with high-grade dysplastic nodules. Multivariate analysis showed that histological dysplastic changes were associated with increased alpha-fetoprotein levels and advanced age, which were both independent predictors of hepatocellular carcinoma development. Histological dysplastic changes, male sex, advanced age, prolonged prothrombin time, and ultrasound appearances were independent predictors of mortality.
 
CONCLUSION. The presence of dysplastic change in liver nodules increased the risk of hepatocellular carcinoma development and death.
 
Key words: Carcinoma, hepatocellular; Cell transformation, neoplastic; Liver cirrhosis; Liver neoplasms; Survival rate
 
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