Effect of combined use of Fructus Schisandrae
and statin on high-fat-diet-induced metabolic
syndrome in rats
E Wat1,2, CF Ng1,2, CL Liu1,2, C Zhang1,2, CM Koon1,2, CP Lau1,2, CW Wong1,2, KY Pang1,2, X Zhang1,2, KP Fung1,2,3, CBS Lau1,2, PC Leung1,2
1 Institute of Chinese Medicine, The Chinese University of Hong Kong
2 State Key Laboratory of Phytochemistry & Plant Resources in West
China (CUHK), The Chinese University of Hong Kong
3 School of Biomedical Sciences, The Chinese University of Hong Kong
1. The combined use of Fructus Schisandrae
aqueous extract (FSE) and atorvastatin (AS)
exerts no further synergistic effect on diet-induced
non-alcoholic fatty liver disease in rats,
compared with rats given AS alone.
2. The use of FSE can protect high-fat-fed rats from AS-induced liver toxicity.
3. Preliminary pharmacokinetic studies suggest that FSE can enhance plasma metabolites of AS but reduce the liver metabolites of AS.
2. The use of FSE can protect high-fat-fed rats from AS-induced liver toxicity.
3. Preliminary pharmacokinetic studies suggest that FSE can enhance plasma metabolites of AS but reduce the liver metabolites of AS.