Characterisation of novel anti-HIV/tuberculosis
natural product analogues
ZW Chen, G Liu, XF Lu, L Liu, X Zhang, TCK Lau, SKW Tsui, YX Kang, PR Zheng, BJ Zheng
AIDS Institute, Department of Microbiology and Research Centre for
Infection and Immunity, Li Ka Shing Faculty of Medicine, The University
of Hong Kong
Key Messages
1. 10-chloromethyl-11-demethly-12-oxo-calanolide A (F18) is an effective antiretroviral
compound in vitro.
2. F18 remains effective against HIV-1 strains that contain various mutations rendering them resistant to non-nucleoside reverse-transcriptase inhibitors.
2. F18 remains effective against HIV-1 strains that contain various mutations rendering them resistant to non-nucleoside reverse-transcriptase inhibitors.