Hong Kong Med J 2024;30(Suppl 3):S26-8
No benefit of additional tramadol or tizanidine to diclofenac for acute low back pain: abridged secondary publication
KKC Hung1,2,3, RPK Lam4, HKH Lee5, YF Choi6, J Tenney7,8, Z Zhong7, KC Chong3, TSI Hui1, TK Wong1, TY Yiu1, SY Chan1, CPY Mok1, LY Leung1, WK Mak9, DTF Sun9, CH Cheng1,2, CA Graham1,2,3
1 Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Accident and Emergency Department, Prince of Wales Hospital, Hong Kong SAR, China
3 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China
4 Department of Emergency Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
5 Accident and Emergency Department, United Christian Hospital, Hong Kong SAR, China
6 Accident and Emergency Department, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China
7 School of Pharmacy, The Chinese University of Hong Kong, Hong Kong SAR, China
8 Pharmacy Department, Canberra Hospital, Australia
9 Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
 
 
  1. There was no significant difference in improvement of functional recovery, pain intensity, and return to work among the three groups of diclofenac plus tramadol, diclofenac plus tizanidine, and diclofenac plus placebo.
  2. Our findings do not support the use of tramadol or tizanidine in addition to diclofenac in patients with acute low back pain.