Statin safety among Chinese adolescents: a Mendelian randomisation study (abridged secondary publication)
SL Au Yeung1, HS Lam2, YH Chan3, CM Schooling1,4
1 School of Public Health, Li Ka Shing Faculty of Medicine, The University
of Hong Kong, Hong Kong SAR, China
2 Department of Paediatrics, Faculty of Medicine, The Chinese University
of Hong Kong, Hong Kong SAR, China
3 Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of
Medicine, The University of Hong Kong, Hong Kong SAR, China
4 Graduate School of Public Health and Health Policy, City University of
New York, New York, United States
- There is limited evidence on the long-term safety of statin use among adolescents.
- As a form of genetic validation, this Mendelian randomisation study used randomly allocated variants within the HMGCR protein-encoding gene (leading to reductions in low-density lipoprotein cholesterol) to infer statin safety based on data from the Hong Kong ‘Children of 1997’ birth cohort.
- Genetic evidence did not suggest substantial safety concerns about statins among Chinese adolescents.
- This proof-of-concept study used a well-characterised birth cohort to infer the safety of drug targets among adolescents.