Gut barrier proteins in diagnosing necrotising
enterocolitis in preterm infants: abridged
secondary publication
EWY Ng1, PC Ng1, HS Lam1, MMT Lam1,2, HM Cheung1, TPY Ma1, KYY Chan1, POR Wong1, KT Leung1, K Li1, TCW Poon1,2
1 Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
2 Pilot Laboratory, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau
1. Our study provides the first evidence that
hepatocarcinoma-intestine-pancreas (HIP) and
intestinal bile acid binding protein (I-BABP) were
specific, novel biomarkers for early diagnosis of
necrotising enterocolitis (NEC).
2. Use of HIP followed by I-BABP significantly improved the diagnostic performance. A stepwise risk stratification scheme for preterm infants suspected of NEC is proposed.
3. This risk stratification scheme can facilitate neonatologists in identification and management of preterm infants with NEC.
2. Use of HIP followed by I-BABP significantly improved the diagnostic performance. A stepwise risk stratification scheme for preterm infants suspected of NEC is proposed.
3. This risk stratification scheme can facilitate neonatologists in identification and management of preterm infants with NEC.