C-terminal truncated hepatitis B virus X protein
regulates tumourigenicity, self-renewal, and
chemoresistance via STAT3/Nanog signalling
pathway: abridged secondary publication
RHH Ching, KMF Sze, EYT Lau, YT Chiu, JMF Lee, IOL Ng, TKW Lee
Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong:
State Key Laboratory for Liver Research & Department of Pathology
1. HBx-ΔC1 (a major C-terminal truncated form
reported with a breakpoint at 130aa) regulates
cancer stem cell properties including tumour
initiation, self-renewal, drug resistance, and
invasiveness.
2. HBx-ΔC1 regulates liver cancer stem cells through Stat3/Nanog cascade, which provides a new insight for the therapeutic intervention for hepatitis B virus–related hepatocellular carcinoma.
2. HBx-ΔC1 regulates liver cancer stem cells through Stat3/Nanog cascade, which provides a new insight for the therapeutic intervention for hepatitis B virus–related hepatocellular carcinoma.