Cytomegalic inclusion disease is a common complication in recipients of organ transplants. In renal transplant recipients, the disease involves the lungs more often than it does the gastrointestinal tract. We report on a recipient of a cadaveric kidney who had cytomegalic inclusion disease that involved both the upper and lower gastro-intestinal tract, and massive gastro-intestinal bleeding that was caused by a large colonic ulcer. Despite treatment with ganciclovir and cytomegalovirus-specific immunoglobulin, the patient died from subsequent complications.