Weight loss versus continuous positive airway pressure therapy for obstructive sleep apnoea on metabolic profile stratified by craniofacial restriction: abridged secondary publication
SSS Ng1, J Woo1, P Cistuilli2, RWW Lee3, JKT Wong4, DSC Hui1
1 Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Department of Sleep Medicine, University of Sydney, Sydney, New South Wales, Australia
3 Department of Respiratory and Sleep Medicine, Gosford Hospital, Gosford, New South Wales, Australia
4 Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Hong Kong SAR, China
- Weight loss by lifestyle modification programme (LMP) achieved more reduction in subclinical inflammation than continuous positive airway pressure (CPAP) therapy at 6 months among obese patients with moderate to severe obstructive sleep apnoea (OSA).
- Weight loss by LMP improved insulin sensitivity better than CPAP therapy at 6 months among obese patients with moderate to severe OSA, with smaller proportion of patients having abnormal glucose regulations by 6 months (46.1% vs 63.6%).
- Baseline sleep apnoea severity was associated with neck circumference, mandibular length, maxillary angle, and mandibular angle.
- Changes of subclinical inflammation and insulin sensitivity were not significantly different between patients with different degrees of craniofacial restriction.
- Only weight loss was associated with the percentage change of apnoea-hypopnoea index at 6 months.