Small molecule of adiponectin receptor agonist—AdipoRon—for Alzheimer disease: abridged
secondary publication
RCL Ng1, M Jian1, M Bunting1, SK Chung2, KH Chan1
1Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong
2School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
1. Chronic oral administration of AdipoRon reverses
spatial learning and memory performance in an
Alzheimer mouse model.
2. AdipoRon crosses the blood-brain barrier and reaches maximum concentration 2 hours after oral administration.
3. AdipoRon enhances neuronal insulin sensitivity and reduces amyloid-β deposition.
4. AdipoRon suppresses amyloid-β-mediated neuroinflammatory responses, exerting protective effects to neurons and synapses in Alzheimer mouse model.
2. AdipoRon crosses the blood-brain barrier and reaches maximum concentration 2 hours after oral administration.
3. AdipoRon enhances neuronal insulin sensitivity and reduces amyloid-β deposition.
4. AdipoRon suppresses amyloid-β-mediated neuroinflammatory responses, exerting protective effects to neurons and synapses in Alzheimer mouse model.