© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
LETTER TO THE EDITOR
Streptococcus bovis bacteraemia should be
investigated for early detection of colorectal pathology
SC Ng, MB, BS; HK Wong, MB, BS; CK So, MB, BS; CW
Lau, FHKAM (Medicine); Jennifer NS Leung, FHKAM (Pathology); WC Tsoi,
FHKAM (Pathology); CK Lee, MD, FHKAM (Medicine)
Hong Kong Red Cross Blood Transfusion Service, Hong
Kong
Corresponding author: Dr CK Lee (ckleea@ha.org.hk)
To the Editor—We read with great interest
the article titled Streptococcus gallolyticus endocarditis—an
uncommon but serious complication of constipation management in the
June issue of the Hong Kong Medical Journal,1 which addresses the
association between endocarditis and Streptococcus gallolyticus, a
subtype of the S bovis group of bacteria.
We would like to share our experience in handling
the same group of bacteria in the setting of the blood transfusion
service. An association between S bovis group bacteraemia (in
particular S gallolyticus subsp. gallolyticus) and colonic
neoplasia is well established.2 Recently, Kwong et al3 identified S
gallolyticus as a colorectal cancer–related microbe.
Reviewing blood transfusion service data from 1998
to 2018, a total of 25 cases of S bovis group bacteraemia were
isolated in our routine bacterial surveillance programme for
platelets. Although these donors were asymptomatic, in a previous study we
recommended referral to public hospitals to rule out possible colonic
diseases and endocarditis.4 In that study, we found that bacteraemia from
S gallolyticus subsp. pasteurianus could be also associated with
underlying colorectal pathology.4 As a result of this connection, we
routinely refer all the cases of S bovis group bacteraemia for
further management, irrespective of the subspecies. Among the 21 donors
successfully referred, 15 donors received a colonoscopy examination. Of
these 15 donors, three (20%) were found to have colonic carcinoma, and
nine (60%) had colonic polyps (Table).
Though the case series is small, we recommend
thorough examination for early detection and treatment of underlying
colorectal pathology among patients with asymptomatic bacteraemia.
Author contributions
All authors had full access to the data and
responsible to the follow up of the donors. SC Ng, HK Wong and CK Lee
wrote the letter. All reviewed and approved the final version for
publication, and take responsibility for its accuracy and integrity.
Conflicts of interest
All authors have no conflicts of interest to
disclose.
References
1. Leung JS. Streptococcus gallolyticus
endocarditis—an uncommon but serious complication of constipation
management. Hong Kong Med J 2019;25:257. Crossref
2. Boleij A, van Gelder MM, Swinkels DW,
Tjalsma H. Clinical importance of Streptococcus gallolyticus
infection among colorectal cancer patients: systematic review and
meta-analysis. Clin Infect Dis 2011;53:870-8. Crossref
3. Kwong TN, Wang X, Nakatsu G, et al.
Association between bacteremia from specific microbes and subsequent
diagnosis of colorectal cancer. Gastroenterology 2018;155:383-90. Crossref
4. Lee CK, Chan HM, Ho PL, et al. Long-term
clinical outcomes after Streptococcus bovis isolation in
asymptomatic blood donors in Hong Kong. Transfusion 2013;53:2207-10. Crossref