FE65 serine-610 phosphorylation and its functional
implications in Alzheimer disease amyloid precursor protein processing
KF Lau1; WN Chow1; JCK Ngo1;
YW Chen2; VKM Tam1; EHY Chan1; C Miller3
1 School of Life Sciences, The Chinese
University of Hong Kong
2 Randall Division of Cell and Molecular
Biophysis, King’s College London
3 Basic and Clinical Neuroscience,
King’s College London
1. FE65 Serine610 (S610) phosphorylation regulates
amyloid precursor protein (APP)/FE65 interaction and FE65-mediated APP
processing.
2. FE65 S610 is phosphorylated by serum- and glucocorticoid-induced kinase 1.
3. The effect of FE65 S610 phosphorylation on APP processing is associated with the role of FE65 in metabolic turnover of APP via the proteasome.
2. FE65 S610 is phosphorylated by serum- and glucocorticoid-induced kinase 1.
3. The effect of FE65 S610 phosphorylation on APP processing is associated with the role of FE65 in metabolic turnover of APP via the proteasome.