Innate immune defect predisposing to severe influenza in a Chinese population
KKW To1; J Zhou1; YQ Song2; IFN Hung3; KY Yuen1
1 Department of Microbiology, The University of Hong Kong
2 School of Biomedical Sciences, The University of Hong Kong
3 Department of Medicine, The University of Hong Kong
 
 
1. Genetic polymorphisms in SFTPB and PDE3A genes are independently associated with severe A(H1N1)pdm09 infection.
2. Surfactant protein B has antiviral activity against influenza A(H1N1)pdm09 infection.
3. PDE3A is an antiviral host factor