Placental biology of Down syndrome in relation to
increased gene dosage
OGW Wong1, HYS Ngan2, ANY
Cheung1
1 Department of Pathology, Queen Mary
Hospital, The University of Hong Kong
2 Department of Obstetrics and
Gynaecology, Queen Mary Hospital, The University of Hong Kong
1. Amyloid precursor protein (APP) is overexpressed
in the placentas of Down syndrome subjects.
2. Inducible APP overexpressed trophoblast cell line models are established.
3. APP overexpression dysregulates trophoblast cell functions.
2. Inducible APP overexpressed trophoblast cell line models are established.
3. APP overexpression dysregulates trophoblast cell functions.