Association of serum folate level with toxicity of
capecitabine in patients with colorectal cancers: a prospective cohort
study
SL Chan1, BBY Ma1, AKC Chan2
1 Department of Clinical Oncology, The
Chinese University of Hong Kong
2 Department of Chemical Pathology, The
Chinese University of Hong Kong
1. A higher serum folate level is associated with a
higher rate of moderate-to-severe toxicity of capecitabine in patients
with colorectal cancer.
2. The safety profile of capecitabine is similar between Chinese and western populations, except for a lower rate of diarrhoea and hand-foot skin reactions in the Chinese population.
3. Future studies are needed to determine whether higher folate intake is associated with a worse toxicity profile during capecitabine treatment in cancer patients.
2. The safety profile of capecitabine is similar between Chinese and western populations, except for a lower rate of diarrhoea and hand-foot skin reactions in the Chinese population.
3. Future studies are needed to determine whether higher folate intake is associated with a worse toxicity profile during capecitabine treatment in cancer patients.