Association of wheeze during the first 18
months of life with indoor nitrogen dioxide,
formaldehyde, and family history of asthma: a
prospective cohort study
ITS Yu1, AM Li1, W Goggins1, JOS Leung2, GYS Chan3, CKC Fung1, CK Chan4, APS Lau4
1 The Chinese University of Hong Kong
2 Department of Health
3 The Hong Kong Polytechnic University
4 Hong Kong University of Science and Technology
1. Indoor exposure to formaldehyde increased
the risk of new onset wheezing, and wheezing
was more common among infants with a family
history of allergy.
2. Indoor exposure to nitrogen dioxide and family history of asthma did not have a significant association with new onset wheezing.
3. Prevention measures to reduce formaldehye exposure in the home environment should be implemented to reduce the future disease burden of asthma in children.
4. If more subjects were recruited for stratified analyses, the possible interactions between family history of asthma or allergy and indoor exposure to formaldehyde on the risk of new onset of wheeze could have been better clarified.
2. Indoor exposure to nitrogen dioxide and family history of asthma did not have a significant association with new onset wheezing.
3. Prevention measures to reduce formaldehye exposure in the home environment should be implemented to reduce the future disease burden of asthma in children.
4. If more subjects were recruited for stratified analyses, the possible interactions between family history of asthma or allergy and indoor exposure to formaldehyde on the risk of new onset of wheeze could have been better clarified.