In recent years there has been an increased number of reports of rhabdomyolysis associated with heroin addiction and other drugs such as cocaine, amphetamines, salicylates, and alcohol. Early diagnosis and treatment can prevent serious complications such as acute renal failure. We describe a case of an intravenous heroin addict with rhabdomyolysis and acute renal failure which required acute haemodialysis. A high index of suspicion for rhabdomyolysis and myoglobinuria is essential in drug overdose patients when admitted to hospital. The prognosis for adequately treated cases of rhabdomyolysis is often excellent.