Hong Kong Med J 2013;19(Suppl 4):S36-8
Development of anti-influenza A compounds: a pilot study
BJ Zheng, CS Chan, KM Poon, F N, CM Ho, CM Che, KY Yuen
Department of Microbiology, The University of Hong Kong
1. There is no effective anti-H5N1 avian influenza agent.
2. A chemical compound—BFDBSC—can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues.
3. This pilot study assessed anti-H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system.
4. Two compounds—FP- BFDBSC and BFB-gallate—showed higher antiviral effects than BFDBSC, whearas the other two—BFB-borneol and BFB-menthol—showed lower antiviral effects. These compounds did not show toxicity.
5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility.
2. A chemical compound—BFDBSC—can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues.
3. This pilot study assessed anti-H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system.
4. Two compounds—FP- BFDBSC and BFB-gallate—showed higher antiviral effects than BFDBSC, whearas the other two—BFB-borneol and BFB-menthol—showed lower antiviral effects. These compounds did not show toxicity.
5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility.