Hong Kong Med J 2009;15(Suppl 2):S33-6
Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein
FWY Sin, SCS Cheng, KT Chan, L Meng, J Yu, Y Xie
Department of Biology, The Hong Kong University of Science and Technology
1. A recombinant adenovirus encoding SARS coronavirus (SARS-CoV) nucleocapsid protein (rAd-N) was constructed.
2. The ability of the rAd-N to induce anti–SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.
2. The ability of the rAd-N to induce anti–SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.