Hong Kong Med J 2024;30(Suppl 5):S4-6
Epidemiology, prognosis, risk factors, and chemopreventive agents for post-colonoscopy colorectal cancer: abridged secondary publication
KS Cheung1, WK Leung1, EWY Chan2, IOL Wong3
1 Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
2 Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China
3 School of Public Health, The University of Hong Kong, Hong Kong SAR, China
 
 
  1. In Hong Kong, post-colonoscopy colorectal cancer (PCCRC) is associated with higher prevalences of distal cancers (>80%) and cancer-specific mortality, compared with detected colorectal cancer. The rate of PCCRC at 3 years is 7.9%.
  2. Predictive factors for PCCRC at 3 years are older age, male sex, history of colonic polyps, polypectomy/biopsy at index colonoscopy, index colonoscopy by a surgical endoscopist, and a higher centre annual colonoscopy volume.
  3. Non-steroidal anti-inflammatory drugs have potential chemoprotective effects against PCCRC.
  4. Statins are potential chemopreventive agents against PCCRC.