Hong Kong Med J 2024;30(Suppl 1):S29-33
Genome-wide DNA methylation profiling for central nervous system embryonal tumours in children: abridged secondary publication
APY Liu1,2, GCF Chan1,2, BHY Chung1, W Yang1, HK Ng3
1 Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
2 Department of Paediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong SAR, China
3 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
 
 
  1. Genome-wide DNA methylation profiling enables tumour classification of central nervous system (CNS) tumour tissues.
  2. Methylation profiling demonstrates utility in the diagnostic process of CNS embryonal tumours, facilitating tumour subgrouping in two-thirds of patients while allowing consideration of alternative diagnoses in one-tenth of patients.
  3. Epigenome-based classification of CNS embryonal tumours stratified patients into prognostically relevant disease subgroups.