Novel dentotropic antimicrobial peptide to prevent dental caries: abridged secondary publication
CH Chu, ML Mei, WKK Wu
1 Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
2 Faculty of Dentistry, University of Otago, New Zealand
3 Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong SAR, China
- GA-KR12 can be successfully synthesised with high purity (98.98%).
- GA-KR12 is a biocompatible stable peptide with antimicrobial and remineralising properties.
- GA-KR12 can significantly reduce the Streptococcus mutans mono-species biofilm and inhibit its metabolism and growth.
- GA-KR12 prevents the demineralisation of tooth hard tissue and enhance the remineralisation of artificial caries on enamel and dentine.
- Grafting a mineralising molecule and an antimicrobial peptide to develop a novel peptide against caries is a viable strategy.